• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Quantitative analysis of transduction cascade with caged-compounds in the cell.

Research Project

Project/Area Number 18700382
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionOsaka University

Principal Investigator

TAKEUCHI Hiroko  Osaka University, 大学院・生命機能研究科, 助教 (10324823)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywords神経科学 / シグナル伝達 / 感覚生理学 / 生体分子 / 生理活性 / 電気生理学 / パッチクランプ法 / 嗅覚神経細胞 / ケージド化合物 / コンフォーカル顕微鏡 / 蛍光物質 / 神経細胞 / 情報伝達 / 嗅細胞 / ナノ / 実時間測定 / 光 / 電気生理 / 嗅覚 / シグナル情報伝達 / 繊毛
Research Abstract

嗅細胞シリア上に発現している情報変換チャネルの局在を更に詳細に調査した結果、シリア上に発現している情報変換チャネル(CNGチャネル・Cl(Caチャネル))が一様に分布していることを明らかにし、局所的なUV刺激により、ケージドCaを誘起させたことによる、Cl(Ca)チャネルの分布を明らかにした。本結果は学会・論文で発表を行った。学会発表は、2006年度 : 国際学会2件、国内学会件、2007年度 : 国際学会2件、国内学会1件、2008年度 : 国際学会3件、国内学会2件を行った。論文は全て査読つき雑誌に受理され、2006年The Journal of General Physiology (Chen et al.,)2008年The Neuroscience(Takeuchi H & Kurahashi T)、アロマリサーチ(Sugahara et al.,)に掲載された。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (39 results)

All 2009 2008 2007 2006 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (27 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Distribution, amplification, and summation of cyclic nucleotide sensitivities within single olfactory sensory cilia2008

    • Author(s)
      Takeuchi H and Kurahashi T
    • Journal Title

      Journal of Neuroscience 28

      Pages: 766-775

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 嗅細胞イオンチャネルの定量解析 ノイズ解析の効率を図るプログラム開発 (MS-Windows application executing the non-stationary noise analysis of whole-cell transient current)2008

    • Author(s)
      菅原亜弓・吉田真理子・竹内裕子
    • Journal Title

      Aroma Research Vol9, No3

      Pages: 233-240

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution, amplification, and summation of cyclic nucleotide sensitivities- within single olfactory sensory cilia2008

    • Author(s)
      Takeuchi H and Kurahashi. T
    • Journal Title

      Journal of Neuroscience 28

      Pages: 766-775

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution, amplification, and summation of cyclic nucleotide sensitivities within single olfactory sensory cilia.2008

    • Author(s)
      Hiroko Takeuchi, Takashi Kurahashi
    • Journal Title

      Journal of Neuroscience. 28

      Pages: 766-755

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly2006

    • Author(s)
      Chen TY, Takeuchi H and Kurahashi T
    • Journal Title

      J Gen Physiol. 128(3)

      Pages: 365-71

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly2006

    • Author(s)
      Chen TY, Takeuchi H, Kurahashi T
    • Journal Title

      Journal of General Physiology 128

      Pages: 365-371

    • Related Report
      2006 Annual Research Report
  • [Presentation] Photolysis of Caged Calcium in the Olfactory Sensory Cilia2009

    • Author(s)
      竹内裕子・倉橋隆
    • Organizer
      日本生理学会
    • Place of Presentation
      新宿京王プラザホテル
    • Related Report
      2008 Annual Research Report
  • [Presentation] MS-Windows application executing the non-stationary noise analysis of whole-cell transient current2009

    • Author(s)
      菅原亜弓・大井華子・竹内裕子・倉橋隆
    • Organizer
      日本生理学会
    • Place of Presentation
      新宿京王プラザホテル
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナノバイオマスキングの分子メカニズム解明2008

    • Author(s)
      竹内裕子・倉橋隆・引地聰
    • Organizer
      JASTS
    • Place of Presentation
      富山市民会館
    • Year and Date
      2008-09-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナノスケール嗅繊毛内Ca制御とCl(Ca)解析2008

    • Author(s)
      竹内裕子・倉橋隆
    • Organizer
      第101回近畿生理学談話会
    • Place of Presentation
      国立循環器病センター
    • Year and Date
      2008-09-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 単離嗅細胞における電位依存性Na+チャネルの定量的解析2008

    • Author(s)
      大井華子・菅原亜弓・竹内裕子・倉橋隆
    • Organizer
      第101回近畿生理学談話会
    • Place of Presentation
      国立循環器病センター
    • Year and Date
      2008-09-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Distribution of the Signal Transduction System in the Single Olfactory Cilia.2008

    • Author(s)
      Takeuchi, H & Kurahashi, T. Spatial
    • Organizer
      Physiological Society of Japan (Invitation symposium, Annual meeting)
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-13
    • Related Report
      2008 Final Research Report
  • [Presentation] A dawn for the nano-olfactory technology : from theories to applications2008

    • Author(s)
      Takashi Kurahashi, Hiroko Takeuchi
    • Organizer
      ECRO
    • Place of Presentation
      スロベニア・ポルトロズ
    • Year and Date
      2008-09-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Visualization, manipulation and recording of nanotube olfactoxy cilia2008

    • Author(s)
      Hiroko Takeuchi・Takashi Kurahashi
    • Organizer
      ISOT
    • Place of Presentation
      アメリカ・サンフランシスコ
    • Year and Date
      2008-07-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mechanism of Olfactory Masking2008

    • Author(s)
      Takashi Kurahashi, Hiroko Takeuchi, Hirohiko Ishida & Satoshi Hikichi
    • Organizer
      ISOT
    • Place of Presentation
      アメリカ・サンフランシスコ
    • Year and Date
      2008-07-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 嗅細胞シリアにおけるケージドカルシウムの光乖離2008

    • Author(s)
      竹内裕子
    • Organizer
      日本生理学会
    • Place of Presentation
      生理学会大会(東京)
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] ナノバイオマスキングの分子メカニズム解明2008

    • Author(s)
      竹内裕子・引地聰・倉橋隆
    • Organizer
      JASTS (The Japanese Association for the Study of Taste and Smell (Annual meeting)
    • Place of Presentation
      富山
    • Related Report
      2008 Final Research Report
  • [Presentation] 嗅覚マスキングに関わる嗅細胞トランスダクションチャネル抑制機構2008

    • Author(s)
      倉橋隆・竹内裕子・石田浩彦・引地聰
    • Organizer
      JASTS (Annual meeting)
    • Place of Presentation
      富山
    • Related Report
      2008 Final Research Report
  • [Presentation] 嗅細胞における信号増幅を司るCl(Ca)チャネルの特性2008

    • Author(s)
      竹内裕子・倉橋隆
    • Organizer
      JASTS (Annual meeting)
    • Place of Presentation
      富山
    • Related Report
      2008 Final Research Report
  • [Presentation] Visualization. manipulation, recording of nanotube olfactory cilia.2008

    • Author(s)
      Takeuchi, H & Kurahashi, T.
    • Organizer
      ECRO(Congress of European Chemoreception Research Organization)
    • Place of Presentation
      スロベニア(ポルトロズ)
    • Related Report
      2008 Final Research Report
  • [Presentation] CNG block may reduce the olfactory sensitivity.2008

    • Author(s)
      Kurahashi, T., Takeuchi, H., Ishida, H & Hikichi, S.
    • Organizer
      ECRO.
    • Place of Presentation
      スロベニア(ポルトロズ)
    • Related Report
      2008 Final Research Report
  • [Presentation] Mechanism of Olfactory Masking2008

    • Author(s)
      Kurahashi, T., Takeuchi, H., Ishida, H & Hikichi, S
    • Organizer
      ISOT (International Symposium on Olfaction and Taste)
    • Place of Presentation
      米国(サンフランシスコ)
    • Related Report
      2008 Final Research Report
  • [Presentation] Visualization, manipulation and recording of nanotube olfactory cilia.2008

    • Author(s)
      Takeuchi, H. & Kurahashi, T.
    • Organizer
      ISOT
    • Place of Presentation
      米国(サンフランシスコ)
    • Related Report
      2008 Final Research Report
  • [Presentation] Photolysis of Caged Calcium in the Olfactory Sensory Cilia.2008

    • Author(s)
      Takeuchi, H. & Kurahashi, T.
    • Organizer
      Physiological Society of Japan (Annual meeting)
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] MS-Windows application executing the non-stationary noise analysis of whole-cell transient current.2008

    • Author(s)
      Sugahara, A., Oi, H., Kurahashi, T & Takeuchi, H.
    • Organizer
      Physiological Society of Japan (Annual meeting)
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] CNG block may reduce the olfactory sensitivity2008

    • Author(s)
      Takashi Kurahashi, Hiroko Takeuchi, Hirohiko Ishida, & Satoshi Hikichi
    • Organizer
      ECRO
    • Place of Presentation
      スロベニア・ポルトロズ
    • Related Report
      2008 Annual Research Report
  • [Presentation] Visualization, manipulation and recording of nanotube olfactory cilia2008

    • Author(s)
      Hiroko Takeuchi・Takashi Kurahashi
    • Organizer
      ECRO
    • Place of Presentation
      スロベニア・ポルトロズ
    • Related Report
      2008 Annual Research Report
  • [Presentation] Spatial Distribution of Transducion System with Nano-scale Resolution in Living Olfactory Cilia2007

    • Author(s)
      竹内裕子
    • Organizer
      AchemS (The Association for Chemoreception Sciences)
    • Place of Presentation
      AchemS meeting (アメリカ・フロリダ)
    • Year and Date
      2007-04-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Distribution of Transduction System with Nano-scale Resolution in Living Olfactory Cilia.2007

    • Author(s)
      Takeuchi, H. & Kurahashi, T. Spatial
    • Organizer
      AchemS (Association for Chemoreception Sciences) (Annual meeting)
    • Place of Presentation
      米国(サラソタ)
    • Related Report
      2008 Final Research Report
  • [Presentation] UV-laser regulation of cytoplasmic factor in living sensory cilia.2007

    • Author(s)
      Takeuchi, H. & Kurahashi, T. Sub-micron
    • Organizer
      Physiological Society of Japan (Annual meeting)
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] Real-time dynamics of molecular elements within the nano-scale olfactory sensory cilia.2006

    • Author(s)
      Takeuchi, H & Kurahashi, T.
    • Organizer
      International Symposium of Olfaction and Taste. (Invitation symposium)
    • Related Report
      2008 Final Research Report
  • [Presentation] 嗅細胞シリアにおける信号増幅機構2006

    • Author(s)
      竹内裕子・倉橋隆
    • Organizer
      日本生理学会
    • Place of Presentation
      前橋
    • Related Report
      2008 Final Research Report
  • [Presentation] MECHANISM OF SIGNL AMPLIFICATION IN THE NEWT OLFACTORY SENSORY CILIA.2006

    • Author(s)
      Takeuchi H & Kurahashi T.
    • Organizer
      AChemS
    • Place of Presentation
      米国(サラソタ)
    • Related Report
      2008 Final Research Report
  • [Book] The Senses: A Comprehensive Reference, Six-Volume Set, 1-6 (Volume 4: Olfaction & Taste 4.28 : Signal Transduction in the Olfactory Receptor Cell)2009

    • Author(s)
      Editoted by Allan Basbaum etal(H Takeuchi , T Kurahashi)
    • Publisher
      Elsevier
    • Related Report
      2008 Final Research Report
  • [Book] The Senses2008

    • Author(s)
      Hiroko Takeuchi & Takashi Kurahashi
    • Total Pages
      11
    • Publisher
      Elsevier
    • Related Report
      2008 Annual Research Report
  • [Book] 嗅細胞イオンチャネルの定量解析2008

    • Author(s)
      菅原亜弓・吉田真理子・竹内裕子
    • Total Pages
      8
    • Publisher
      フレグランスジャーナル
    • Related Report
      2008 Annual Research Report
  • [Book] 「第4章第2項 : 嗅細胞のイオンチャネル特性」匂いと香りの科学2007

    • Author(s)
      竹内裕子
    • Publisher
      朝倉書店
    • Related Report
      2008 Final Research Report
  • [Book] 匂いと香りの科学2007

    • Author(s)
      澁谷達明, 市川眞澄(編者)(PP87-93;竹内裕子)
    • Total Pages
      241
    • Publisher
      朝倉書店
    • Related Report
      2006 Annual Research Report
  • [Remarks]

    • URL

      http://saturn.bpe.es.osaka-u.ac.jp/kura_pub/kurahasi_x.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi