Experimental and Clinical Study on the Effect of Lifestyle-Related Disease Prevention by Whole Grain and Lignans

• Project/Area Number: 18700624
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Research Institute for Production Development
• Principal Investigator: SAGARA Miki Research Institute for Production Development, 予防栄養医学研究室, 研究員 (00333287)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥6,920,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000); Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 生活習慣病 / 小麦全粒粉 / リグナン / 介入研究 / SHR / NDmcr-cp(cp / cp) / 植物性エストロゲン / 小麦アリューロン / 大豆 / 血圧 / 血糖値 / 食物繊維

Research Abstract

The effects of whole wheat which contains phytoestrogen, lignans, on the risks of metabolic syndrome were studied experimentally and clinically. Firstly, dietary wheat aleurone, rich in dietary fiber and lignans was more effective for obese spontaneously hypertensive rats in reducing blood pressure, blood glucose, HOMA-IR and 24-hour urinary sodium excretion than dietary soy rich in isoflavones. Secondly, whole wheat intake showed a trend toward a decrease in body fat and an increase in defecation frequency among young women.

Research Products

• [Journal Article] Effect of dietary wheat aleurone on blood pressure and blood glucose and its mechanisms in obese spontaneously hypertensive rats : preliminary report on comparison with a soy diet (2007)
  • Author(s): Miki Sagara, Mari Mori, Hideki Mori, Satoru Tsuchikura, Yukio Yamori
  • Journal Title: Clin.Exp.Pharmacol.Physiol. 34(s1) Pages: 37-39
• [Journal Article] Effect of Dietary Wheat Aleurone on Blood Glucose and its Mechanisms in Obese Spontaneously Hypertensive Ratts(SHR/Ndmcrop(cp'cp))Preliminary Report on Comparison asoy diet (2007)
  • Author(s): Miki Sagara
  • Journal Title: Climical and Experimental Phamacology and Physiology 34
  • Peer Reviewed
• [Presentation] Blood Pressure and Blood Glucose Reduction by Dietary Wheat Aleuron and its Mechanisms in Obese Spontaneously Hypertensive Rat (SHR/NDmcr-cp (cp/cp)).Preliminary Report on the Comparison with Soy Diet. (2006)
  • Author(s): Sagara M, Mori M, Mori H, Tuchikura S, Yamori Y.
  • Organizer: 21st International Society of Hypertension.
  • Place of Presentation: Hukuoka
• [Presentation] Blood Pressure and Blood Glucose Reduction by Dietary Wheat Aleuron and its Mechanisms in Obese Spontaneously Hypertensive Rat (SHR/NDmcr-cp (cp/cp)). Preliminary Report on the Comparison with Soy Diet. (2006)
  • Author(s): Sagara M, Mori M, Mori H, Tuchikura S, Yamori Y.
  • Organizer: 2nd International Symposium on Lifestyle Related Diseases.
  • Place of Presentation: Nishinomiya
• [Presentation] Blood Pressure and Blood Glucose Reduction by Dietary Wheat Aleuron and its Mechanisms in Obese Spontaneously Hypertensive Rat (SHR/NDmcr-cp (cp/cp)). (2006)
  • Author(s): M Sagara, M Mori, H Mori, S Tuchikura, Y Yamori.
  • Organizer: 12th International SHR Symposium.
  • Place of Presentation: Kyoto