| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
|
|---|
| Research Abstract |
In this study, to investigate the effect of maternal nutrition, in particular the essential fatty acid (EFA) ratio, on the development of overt diabetes in the offspring, we prepared chows with n-6/n-3 EFA ratios of 3.0 and 14.5, and provided them to pregnant female NOD mice, a type 1 diabetes model. The present study suggests that the maternal dietary n-6/n-3 EFA ratio modifies the expression of IAA and immune response in the offspring, which might further affect the development of overt diabetes, and a diet with a low n-6/n-3 EFA ratio can prolong the honeymoon period after the onset of type 1 diabetes.
|
