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血小板内在性VEGF-Aを分子標的とする新規大腸癌治療の臨床及び分子生物学的研究

Research Project

Project/Area Number 18F16420
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section外国
Research Field Digestive surgery
Research InstitutionKagoshima University

Principal Investigator

井本 浩  鹿児島大学, 医歯学域医学系, 教授 (60274461)

Co-Investigator(Kenkyū-buntansha) ARYAL BIBEK  鹿児島大学, 医学部, 外国人特別研究員
Project Period (FY) 2018-04-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2018: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsVEGF / serotonin / HCC / CRC / VWF
Outline of Annual Research Achievements

Our project is 1) to examine the kinetics of intra-platelet VEGF-A in bevacizumab (Avastin) treated colorectal cancer (CRC) patients, and 2) to study dynamics of various intra-platelet growth factor in patients with Hepatocellular carcinoma (HCC). We also conducted in vitro and ex vivo experiments to investigate the bearing of bevacizumab on the intra-platelet VEGF-A. Following four major results were obtained from this grant.
1. We observed a perioperative exhaustion (depletion) of intra-platelet serotonin concentrations in patients who developed early HCC recurrence and this was able to independently predict HCC recurrence [Aryal et. al, Journal of Cancer (2017)].
2. Platelet-derived growth factor-BB (PDGF-BB) was significantly diminished in patients with cancer recurrence. [Aryal B, et al. Journal of Oncology (2019); article id 1925315].
3. We observed a significant elevation of intra-platelet vWF during liver regeneration; moreover, patients who could not achieve marked rise in post-resection intra-platelet vWF concentration were found to have increased incidence of post-resection liver dysfunction [Aryal B, et al. Under Review (2019)].
4. We performed experiments using an ex vivo and in vitro models to examine the effect of bevacizumab and pegaptanib on IP VEGF-A neutralization, suggesting that the intra-platelet VEGF-A could influence the impact of bevacizumab treatment, as platelets represent a major reservoir of VEGF.
I appreciated this funding and would like to proceed more to accomplish this series of the project.

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Report

(1 results)
  • 2018 Annual Research Report
  • Research Products

    (4 results)

All 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Therapeutic implication of platelets in liver regeneration -hopes and hues.2018

    • Author(s)
      Bibek Aryal
    • Journal Title

      EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY

      Volume: 12 Pages: 1219-1228

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deciphering Platelet Kinetics in Diagnostic and Prognostic Evaluation of Hepatocellular Carcinoma2018

    • Author(s)
      Aryal Bibek、Yamakuchi Munekazu、Shimizu Toshiaki、Kadono Jun、Furoi Akira、Gejima Kentaro、Komokata Teruo、Hashiguchi Teruto、Imoto Yutaka
    • Journal Title

      Canadian Journal of Gastroenterology and Hepatology

      Volume: 2018 Pages: 1-9

    • DOI

      10.1155/2018/9142672

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Perioperative Serum PDGF-BB Characterizes Patients with Post- Resection HCC Recurrence2018

    • Author(s)
      Bibek Aryal
    • Organizer
      Thirtieth Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery
    • Related Report
      2018 Annual Research Report
  • [Presentation] Exhaustion of Platelet Kinetics and its Implication in Post-resection HCC Recurrence2018

    • Author(s)
      Bibek Aryal
    • Organizer
      European Society of Medical Oncology (ESMO) Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2018-05-01   Modified: 2024-03-26  

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