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High-throughput, single-cell optofluidic platform for point-of-care diagnosis

Research Project

Project/Area Number 18F18716
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section外国
Research Field Life / Health / Medical informatics
Research InstitutionThe University of Tokyo

Principal Investigator

合田 圭介  東京大学, 大学院理学系研究科(理学部), 教授 (70518696)

Co-Investigator(Kenkyū-buntansha) YAN SHENG  東京大学, 理学(系)研究科(研究院), 外国人特別研究員
Project Period (FY) 2018-10-12 – 2021-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2019: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2018: ¥800,000 (Direct Cost: ¥800,000)
KeywordsOptofluidics / imaging flow cytometry
Outline of Annual Research Achievements

Two breakthrough technologies are generated with the completion of this project. The first one is intelligent platelet aggregate classifier (iPAC) that performs high-throughput imaging and intelligent analysis of platelet aggregates produced by different agonists and classifies platelet aggregates by agonist type. Our finding that platelet aggregates can be classified by agonist type through their morphology is unprecedented as it has never been reported previously. The information about the driving factors behind the formation of platelet aggregates is expected to lead to a better understanding of the underlying mechanism of platelet aggregation and open a window on an entirely new class of clinical diagnostics, pharmacometrics, and therapeutics. The second one is the virtual optofluidic time-stretch quantitative phase imaging, which generates “virtual” phase images from their corresponding bright-field images by using a deep neural network trained with numerous pairs of bright-field and phase images and identifies cancer cells from white blood cells based on their bright-field and virtual phase images. The fellow, Dr Yan, has presented his work in a prestigious international conference (Australia and New Zealand Nanofluidics and Microfluidics conference). Meanwhile, 3 manuscripts are generated from this project.

Research Progress Status

翌年度、交付申請を辞退するため、記入しない。

Strategy for Future Research Activity

翌年度、交付申請を辞退するため、記入しない。

Report

(2 results)
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (5 results)

All 2020 2019

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (1 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Virtual optofluidic time-stretch quantitative phase imaging2020

    • Author(s)
      1.Haochen Yan, Yunzhao Wu, Yuqi Zhou, Muzhen Xu, Petra Paiè, Cheng Lei, Sheng Yan, and Keisuke Goda
    • Journal Title

      APL Photonics

      Volume: 5, 046103 Issue: 4 Pages: 1-10

    • DOI

      10.1063/1.5134125

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intelligent frequency-shifted optofluidic time-stretch quantitative phase imaging2020

    • Author(s)
      2.Yunzhao Wu, Yuqi Zhou, Chun-Jung Huang, Hirofumi Kobayashi, Sheng Yan, Yasuyuki Ozeki, Yingli Wu, Chia-Wei Sun, Atsushi Yasumoto, Yutaka Yatomi, Cheng Lei, Keisuke Goda
    • Journal Title

      Optics Express

      Volume: Vol. 28, Issue 1 Issue: 1 Pages: 519-532

    • DOI

      10.1364/oe.380679

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intelligent classification of platelet aggregates by agonist type2020

    • Author(s)
      3.Yuqi Zhou, Atsushi Yasumoto, Cheng Lei, Chun-Jung Huang, Hirofumi Kobayashi, Yunzhao Wu, Sheng Yan, Chia-Wei Sun, Yutaka Yatomi, Keisuke Goda
    • Journal Title

      eLife

      Volume: 9, e52938

    • DOI

      10.7554/elife.52938

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Top sheath flow-assisted secondary flow particle manipulation in microchannels with the slanted groove structure2019

    • Author(s)
      Qianbin Zhao; Dan Yuan, Shi-Yang Tang, Guolin Yun Sheng Yan, Jun Zhang, Weihua Li
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: 6 Issue: 1 Pages: 23-23

    • DOI

      10.1007/s10404-018-2174-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Isolation and identification of rare cells in whole blood by time-stretch microscopy with a microfluidic sorter2019

    • Author(s)
      Sheng Yan
    • Organizer
      Advances in Microfluidics & Nanofluidics,
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited

URL: 

Published: 2018-10-15   Modified: 2024-03-26  

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