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3 dimensional imaging of photochemical quantum magnetic compasses.

Research Project

Project/Area Number 18H01184
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
Research InstitutionSaitama University

Principal Investigator

前田 公憲  埼玉大学, 理工学研究科, 准教授 (70229300)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Granted (Fiscal Year 2022)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2022: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Keywordsスピン / スピン動力学 / 分子磁気感受 / 磁場効果 / クリプトクロム / 磁気感受 / 電子スピン共鳴 / 光シグナル / ラジカル対 / 電子スピン / 蛋白質 / スピン化学 / キャビティリングダウン / 低磁場効果 / 磁気コンパス / 量子スピン動力学
Outline of Annual Research Achievements

1.大腸菌によるクリプトクロムの合成:昨年に引き続き埼玉大学畠山准教授と共同してクリプトクロム合成実験を進めた。クリプトクロムの合成はおおむね成功しているが、精製するための装置がコロナ下と半導体不足の結果導入が大幅に遅れ、昨年度末に導入に成功した。現在、導入した装置を用いてサンプルの精製に着手している。そのような中で、並行してクリプトクロムに新しいコドンを導入したスピンラベル系の開発を行っている。そのためにそのテスト実験が進められている。
2.微量サンプル測定法の開発:昨年制作したキャビティシステムを利用しつつ、新たに導入した光源を適用して、究極的な時間分解型キャビティ過渡吸収装置をほぼ完成させた。この装置は昨年報告したパンププローブ型の過渡吸収とは異なり、パルストレインを用いて単発の励起により一度に時間分解および波長分解信号を測定可能となった。この手法について特許を出願した。このキャビティにおいて吸光度の100倍程度の増幅,またパルスレーザの揺らぎによるデータのばらつきを克服して,吸光度10^-4~10^-5程度の磁場効果を測定出来た.
3.色素分子とドラックデリバリタンパク質とのバインドによるラジカル対のダイナミクスとその磁場効果のまとめ:論文執筆中だが、新たに分子動力学計算を加えてバインド位置等を特定し、それらをサポートするESRデータの測定にも成功しほぼ完成した。
4.低磁場効果と磁場スイッチングによる低磁場効果の新しい解析法の発見:これまで、低磁場効果についていくつかの議論がなされてきたが、その磁場効果の形状が似ているために、メカニズムに対するスピン系のコヒーレンスの効果が明らかではなかった。磁場スイッチング法を低磁場領域で実現することに成功し、コヒーレンスの効果について明らかにしつつある。現在理論計算を含めた解析を進めている。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

タンパク質精製がやや遅れているが、来年度中にこれらの精製を完了できると考える。完了したのち測定したい。多次元測定にむけての測定装置開発もほぼ終わっており、研究の目的の一つである高感度測定法の特許出願も終えたため、発表が可能となった。現在それらを利用した最終的な測定と、これまでタンパク質で得られたデータの解析とそれによる論文執筆が進んでいる。

Strategy for Future Research Activity

クリプトクロム等のサンプル合成は進んでいるが、今後その精製過程を進めていく。さらにすでにたんぱく質にバインドした色素系におけるラジカル対のダイナミクス測定と,低磁場効果についての成果を発表する事ができる。このようにこれまでの成果の総まとめを行い公表していく。同時に新しい研究の方向として、磁場スイッチング実験の多次元化にむけた作業や任意波形発生装置を用いた反応制御研究も行なっていく。

Report

(4 results)
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(58 results)

All 2022 2021 2020 2019 2018

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results) Presentation (50 results) (of which Int'l Joint Research: 30 results,  Invited: 23 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 渡り鳥の光化学コンパスー生物と量子力学と制御2022

    • Author(s)
      前田公憲、立野明宏
    • Journal Title

      計測と制御

      Volume: 61 Pages: 25-30

    • NAID

      130008143475

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low magnetic field effects on a photoinduced electron transfer reaction in an ionic liquid2021

    • Author(s)
      Harada Nanshi、Matsuo Taisuke、Yago Tomoaki、Maeda Kiminori、Wakasa Masanobu
    • Journal Title

      Chem. Phys. Lett.

      Volume: 773 Pages: 138569-138569

    • DOI

      10.1016/j.cplett.2021.138569

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 量子スピンダイナミクスと動物の磁気感受2020

    • Author(s)
      前田公憲
    • Journal Title

      光学

      Volume: 49

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Quantum control of radical pair reactions by local optimization theory2020

    • Author(s)
      Masuzawa Kenta、Sato Masaya、Sugawara Michihiko、Maeda Kiminori
    • Journal Title

      The Journal of Chemical Physics

      Volume: 152 Pages: 014301-014301

    • DOI

      10.1063/1.5131557

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics of flavin containing radical pairs in SDS micellar media probed by static and pulse magnetic field effect and pulse ADMR2019

    • Author(s)
      Maeda Kiminori、Naito Yusuke
    • Journal Title

      Molecular Physics

      Volume: 印刷中 Pages: 1-10

    • DOI

      10.1080/00268976.2019.1580779

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-molecule spectroscopy of radical pairs, a theoretical treatment and experimental considerations2018

    • Author(s)
      Noboru Ikeya, Egor A. Nasibulov, Konstantin L. Ivanov, Kiminori Maeda & Jonathan R. Woodward
    • Journal Title

      Molecular Physics

      Volume: Online Pages: 1-14

    • DOI

      10.1080/00268976.2018.1559954

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Gigantic Magnetic Field Effect on the Long-Lived Intermolecular Charge-Separated State Created at the Nonionic Bilayer Membrane2018

    • Author(s)
      Miura Tomoaki、Maeda Kiminori、Oka Yoshimi、Ikoma Tadaaki
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 122 Pages: 12173-12183

    • DOI

      10.1021/acs.jpcb.8b08389

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラジカル対を観測するためのスピン操作と時間分解計測2022

    • Author(s)
      前田公憲
    • Organizer
      第24回 “光”機到来!Qコロキウム
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reaction Dynamics Stimulated by Static and Oscillating Magnetic Fields2021

    • Author(s)
      Kiminori Maeda
    • Organizer
      MolMag-2021,Joint conference of IX International conference "HIGH-SPIN MOLECULES AND MOLECULAR MAGNETS", XIV Russian-Japanese workshop "OPEN SHELL COMPOUNDS AND MOLECULAR SPIN DEVICES"
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of high-sensitivity fluorescence-based microspectroscopy for exploring magnetic field effects in biological systems2021

    • Author(s)
      Mizuki Kohmura, Kiminori Maeda, Lewis M Antill
    • Organizer
      ISMAR-APNMR-NMRSJ-SEST2021合同国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of an ultra-compact cell for RYDMR2021

    • Author(s)
      Harutaka Sano, Hiroki Nagashima, Akihiro Tateno, Lewis M Antill, Kiminori Maeda
    • Organizer
      ISMAR-APNMR-NMRSJ-SEST2021合同国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transient Absorption Measurement by Cavity Ringdown Method and Observation of Magnetic Field Effect2021

    • Author(s)
      Ryohei Yamaga, Kiminori Maeda
    • Organizer
      ISMAR-APNMR-NMRSJ-SEST2021合同国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Temperature dependence of radical pair dynamics in the binding pocket of bovine serum albumin2021

    • Author(s)
      Sota Fukumoto, Nana Iwata, Lewis Antill, Kiminori Maeda
    • Organizer
      ISMAR-APNMR-NMRSJ-SEST2021合同国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Coherent Control of Radical Pair Dynamics in Low and High Field Regime2021

    • Author(s)
      Akihiro Tateno, Kenta Masuzawa, Hiroki Nagashima, Michihiko Sugawara, Kiminori Maeda
    • Organizer
      ISMAR-APNMR-NMRSJ-SEST2021合同国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of the three-dimensional structure formed by BSA with a ligand2021

    • Author(s)
      Shuhei Arai, Hiroki Nagashima, Lewis M Antill, Kiminori Maeda
    • Organizer
      ISMAR-APNMR-NMRSJ-SEST2021合同国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Low field effects on the yield of benzophenone anion radical generated by photoinduced reaction in an ionic liquid2021

    • Author(s)
      Ren Sakaguchi, Kiminori Maeda, Tomoaki Yago, Masanobu Wakasa
    • Organizer
      ISMAR-APNMR-NMRSJ-SEST2021合同国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigating protein-ligand complexes with magnetic field effect-based fluorescence fluctuation spectroscopy2021

    • Author(s)
      Lewis M Antill, Mizuki Kohmura, Kiminori Maeda
    • Organizer
      ISMAR-APNMR-NMRSJ-SEST2021合同国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anisotropic Radical Pair Reaction stimulated by AWG-based Elecron Spin Resonance2021

    • Author(s)
      Kiminori Maeda, Kenta Masuzawa, Akihiro Tateno, Hiroki Nagashima, Michihiko Sugawara
    • Organizer
      ISMAR-APNMR-NMRSJ-SEST2021合同国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Magnetoreception and magnetic resonance techniques on radical pair reactions2021

    • Author(s)
      Kiminori Maeda
    • Organizer
      Intercontinental Magnetic Resonance Conference on Methods and Applications ICONS3
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exploring magnetic field effects in biomolecules with high-sensitivity fluorescence spectroscopy2021

    • Author(s)
      アンテルルイス,香村泉希,深井歩実,前田公憲
    • Organizer
      第3回量子生命科学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ラジカル対の低磁場効果測定とメカニズム2021

    • Author(s)
      松尾太亮,岩田菜々,長嶋宏樹,矢後友暁,前田公憲
    • Organizer
      第3回量子生命科学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 磁場効果に対するフローレイトの影響の研究2021

    • Author(s)
      香村泉希,前田公憲,アンテルルイス
    • Organizer
      第3回量子生命科学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Pulse and AWG-based RF magnetic field effects on chemical reaction kinetics2021

    • Author(s)
      Kiminori Maeda
    • Organizer
      Modern Development of Magnetic Resonance 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Quantum control of radical pair reactions by arbitrary wave generator2021

    • Author(s)
      K. Masuzawa, A. Tateno, H. Nagashima, M. Sugawara, K. Maeda
    • Organizer
      Pacifichem 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ラジカル対機構による生体分子システムの磁気感受2021

    • Author(s)
      前田公憲
    • Organizer
      日本生化学会
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Radical pair dynamics in binding pockets of proteins and the origin of the low field magnetoreceptions.2021

    • Author(s)
      Kiminori Maeda
    • Organizer
      Big Quantum Biology Meeting,2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Magnetosensitive radical pair dynamics in protein.2021

    • Author(s)
      Nana Iwata, Lewis M.Antill and Kiminori Maeda
    • Organizer
      RIKEN CEMS Topical Meeting Online
    • Related Report
      2020 Annual Research Report
  • [Presentation] Anisotropic reaction control of radical pairsbased on the local optimization theory2020

    • Author(s)
      K. Masuzawa, A. Tateno, H. Nagashima, M. Sugawara, K. Maeda.
    • Organizer
      VI International School for Young Scientists 2020 “Magnetic Resonance and Magnetic Phenomena in Chemical and Biological Physics”
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurement of the quenching kinetics of FAD by biomolecules studied by magnetic field switching experiments2020

    • Author(s)
      Taichi Sato, Akihiro Sakashita, Lewis M. Antill, Kiminori Maeda
    • Organizer
      VI International School for Young Scientists 2020 “Magnetic Resonance and Magnetic Phenomena in Chemical and Biological Physics”
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electron spin polarization and magnetic field effect caused by radical pair formation2020

    • Author(s)
      Kiminori Maeda
    • Organizer
      VI International School for Young Scientists 2020 “Magnetic Resonance and Magnetic Phenomena in Chemical and Biological Physics”
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 磁場効果から見たタンパク質バインディングポケット中でのラジカル対挙動2020

    • Author(s)
      岩田 菜々, アンテル ルイス, 前田 公憲
    • Organizer
      生物物理学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] クリプトクロムタンパク質の光誘起構造変化ダイナミクス2020

    • Author(s)
      アンテル ルイス, 坂田 一郎, 畠山 晋, 前田 公憲
    • Organizer
      生物物理学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] AWGを用いたラジカル対の反応異方性制御2020

    • Author(s)
      増澤健太, 立野明宏, 長嶋宏樹, 菅原道彦, 前田公憲
    • Organizer
      第59回電子スピンサイエンス学会(SEST2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 磁場スイッチ法によるFADにおける三重項・ビラジカル疑似平衡状態のクエンチング反応測定2020

    • Author(s)
      佐藤太一, Lewis M. Antill,前田公憲
    • Organizer
      第59回電子スピンサイエンス学会(SEST2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] ラジカル対のコヒーレントコントロール2020

    • Author(s)
      立野明宏,増澤健太,菅原道彦,前田公憲
    • Organizer
      第59回電子スピンサイエンス学会(SEST2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] キャビティリングダウン法による過渡吸収測定と磁場効果の観測2020

    • Author(s)
      山家遼平、前田公憲
    • Organizer
      第59回電子スピンサイエンス学会(SEST2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] ラジカル対のコヒーレントコントロール2020

    • Author(s)
      立野明宏,増澤健太,菅原道彦,前田公憲
    • Organizer
      CSJフェスタ2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] Quantum Control of Radical Pair Reaction by AWG-based Electron Spin Resonance2020

    • Author(s)
      K. Masuzawa, A. Tateno, H. Nagashima, M. Sugawara, K. Maeda
    • Organizer
      3rd The International Forum on Quantum Metrology & Sensing(IFQMS)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 磁気感受に対するラジオ波の効果と電子スピン共鳴2020

    • Author(s)
      増澤 健太,立野 明宏,長嶋 宏樹,前田 公憲
    • Organizer
      第2回量子生命科学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Understanding the photoinduced structural dynamics of cryptochrome proteins2020

    • Author(s)
      Antill Lewis M. 、竹見 祥大、坂田 一郎、畠山 晋、前田 公憲
    • Organizer
      第2回量子生命科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] タンパク質系の光磁気感受2019

    • Author(s)
      前田公憲
    • Organizer
      量子生命科学会 第1回大会(量子生命科学研究会 第3回学術集会)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Reaction control by optimized radio-frequency magnetic field2019

    • Author(s)
      Kiminori Maeda
    • Organizer
      The 6th Awaji International Workshop on “Electron Spin Science & Technology: Biological and Materials Science Oriented Applications
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemically induced hyperpolarization of electron spins2019

    • Author(s)
      Kiminori Maeda
    • Organizer
      16th International Symposium on Spin and Magnetic Field Effects in Chemistry and Related Phenomena (Spin Chemistry Meeting 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Probing and controlling transient radical pairs by static and AWG based RF fields in low field regime2019

    • Author(s)
      Kiminori Maeda
    • Organizer
      16th International Symposium on Spin and Magnetic Field Effects in Chemistry and Related Phenomena (Spin Chemistry Meeting 2019)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 任意波形発生装置を用いるラジカル対の化学反応制御2019

    • Author(s)
      増澤 健太,佐藤将也,菅原道彦,前田公憲
    • Organizer
      第13回分子科学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Quantum-mechanical effects on the reaction dynamics of radical pairs in biomolecular systems2019

    • Author(s)
      Kiminori Maeda
    • Organizer
      化学系学協会東北大会/Joint Meeting of the Tohoku Area Chemistry Societies
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 磁場スイッチング実験による低磁場効果の解析2019

    • Author(s)
      松尾 太亮,前田公憲
    • Organizer
      第58回電子スピンサイエンス学会年会(SEST2019),第58回NMR討論会との連合大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] バインディングポケット内部で生成するラジカル対のダイナミクス2019

    • Author(s)
      岩田 菜々,前田公憲
    • Organizer
      第58回電子スピンサイエンス学会年会(SEST2019),第58回NMR討論会との連合大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Radical Pairs in Proteins2019

    • Author(s)
      Kiminori Maeda
    • Organizer
      第58回電子スピンサイエンス学会年会(SEST2019),第58回NMR討論会との連合大会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Radical pairs confined in the binding pockets of BSA proteins2019

    • Author(s)
      Kiminori Maeda
    • Organizer
      the 13th Japanese-Russian Workshop on “Open Shell Compounds and Molecular Spin Devices
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Magnetic Field Switching technique exploring the LFE2019

    • Author(s)
      Kiminori Maeda
    • Organizer
      5th Kanto Spin Chemistry Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Quenching mechanism of FAD by biomolecules studied by magnetic field switching technique2019

    • Author(s)
      Taichi Sato
    • Organizer
      5th Kanto Spin Chemistry Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Reaction control of radical pairs by optimized radiowave field”2019

    • Author(s)
      Kiminori Maeda
    • Organizer
      The 6th OCU International WS on Quantum Chemistry/Quantum Chemical Calculations on Quantum Computers: Quantum Algorithms
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Probing and controlling transient radical pairs by time resolved pulse magnetic field and magnetic resonance effects on reaction yield.2018

    • Author(s)
      Kiminori Maeda, Yusuke Naito, Masaya Sato, Nana Iwata, Taisuke Matsuo.
    • Organizer
      International-Conference on Coordination Chemistry (ICCC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The pulse magnetic field and radio-wave effect on the radical pair dynamics in biologically related systems2018

    • Author(s)
      Kiminori Maeda, Nana Iwata, Masaya Sato
    • Organizer
      III International Conference "Spin physics, spin chemistry and spin technology" (SPCT-2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Probing and controlling transient radical pairs by pulse magnetic field and RF field in low field regime2018

    • Author(s)
      Kiminori Maeda
    • Organizer
      Third Joint Conference of APES and IES Symposium 2018.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 時間分解反応収量検出EPR法の進歩,実験と理論2018

    • Author(s)
      内藤祐輔、佐藤将也、増澤健太、菅原道彦、〇前田公憲
    • Organizer
      第57回電子スピンサイエンス学会年会
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 過渡吸収測定装置、および、測定方法2022

    • Inventor(s)
      前田公憲
    • Industrial Property Rights Holder
      前田公憲
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2021 Annual Research Report

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Published: 2018-04-23   Modified: 2022-12-28  

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