Establishing evaluation platform for contrast agent of functional photo-acoustic diagnosis
| Project/Area Number |
18H01449
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 21030:Measurement engineering-related
|
|---|
| Research Institution | Tokyo Institute of Technology |
|---|
Principal Investigator |
Nakamura Kentaro 東京工業大学, 科学技術創成研究院, 教授 (20242315)
|
|---|
| Project Period (FY) |
2018-04-01 – 2023-03-31
|
| Project Status |
Completed (Fiscal Year 2022)
|
| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2022: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2021: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
|---|
| Keywords | 超音波 / 光超音波 / レーザ / 半導体レーザ / 造影剤 / イメージング / 変調光 / パルス光 / 光音響 / 診断装置 / 強度変調 |
|---|
| Outline of Final Research Achievements |
Photoacoustic (PA) imaging is an imaging technology to utilize ultrasonic signals generated through PA effect of blood or tissues with a pulsed illumination of light. This study was started with developments of evaluation method of contrast agents for PA imaging. Utilizing cost-effective semiconductor lasers, two methods based on the different setup were developed. One was composed of a modulated light and a resonant air tube, the other was a combination of a pulsed light and a thin glass tube with inner diameter of less than 1 mm. The optimum pulse duration was found for the given inner diameter of the glass tube to efficiently utilize the acoustic resonances. It was found that the PA signals from the thin tube exhibited the directivity specific to the related acoustic mode. In addition, characteristics of PA signal for a thin silicone tube were studied.
|
| Academic Significance and Societal Importance of the Research Achievements |
光音響イメージングは新しい医用画像モダリティとして注目されており、専用造影剤の開発も進められている。個々の画像化装置の特性に依存しない造影剤感度の定量的な評価方法は専用造影剤の開発に有用であると考えられる。また、入手容易なさまざまな光波長の半導体レーザ群から光源を選べることも実用的価値がある。また、この評価装置の開発過程で明らかになった細管の幾何学寸法と発生する光音響信号の中心周波数や指向特性などの関係とその物理的機序の解明には学術的意義がある。さらに細いシリコンチューブでの実験で明らかになった光音響信号の特徴はイメージング装置の開発の上でも有用な情報であると考えられる。
|
Report
(6 results)
Research Products
(12 results)
