• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishing evaluation platform for contrast agent of functional photo-acoustic diagnosis

Research Project

Project/Area Number 18H01449
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 21030:Measurement engineering-related
Research InstitutionTokyo Institute of Technology

Principal Investigator

Nakamura Kentaro  東京工業大学, 科学技術創成研究院, 教授 (20242315)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2022: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2021: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords超音波 / 光超音波 / レーザ / 半導体レーザ / 造影剤 / イメージング / 変調光 / パルス光 / 光音響 / 診断装置 / 強度変調
Outline of Final Research Achievements

Photoacoustic (PA) imaging is an imaging technology to utilize ultrasonic signals generated through PA effect of blood or tissues with a pulsed illumination of light. This study was started with developments of evaluation method of contrast agents for PA imaging. Utilizing cost-effective semiconductor lasers, two methods based on the different setup were developed. One was composed of a modulated light and a resonant air tube, the other was a combination of a pulsed light and a thin glass tube with inner diameter of less than 1 mm. The optimum pulse duration was found for the given inner diameter of the glass tube to efficiently utilize the acoustic resonances. It was found that the PA signals from the thin tube exhibited the directivity specific to the related acoustic mode. In addition, characteristics of PA signal for a thin silicone tube were studied.

Academic Significance and Societal Importance of the Research Achievements

光音響イメージングは新しい医用画像モダリティとして注目されており、専用造影剤の開発も進められている。個々の画像化装置の特性に依存しない造影剤感度の定量的な評価方法は専用造影剤の開発に有用であると考えられる。また、入手容易なさまざまな光波長の半導体レーザ群から光源を選べることも実用的価値がある。また、この評価装置の開発過程で明らかになった細管の幾何学寸法と発生する光音響信号の中心周波数や指向特性などの関係とその物理的機序の解明には学術的意義がある。さらに細いシリコンチューブでの実験で明らかになった光音響信号の特徴はイメージング装置の開発の上でも有用な情報であると考えられる。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (12 results)

All 2023 2022 2021 2020

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Directivity of photoacoustically generated ultrasound from a thin tube embedded in the soft phantom2023

    • Author(s)
      Wang Kun, Wada Yuji, Nakamura Kentaro
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 62 Issue: SJ Pages: SJ1020-SJ1020

    • DOI

      10.35848/1347-4065/acb7fd

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deformation measurement of liquid-filled elastic tube embedded in soft material using optimal pulse width method under photoacoustic excitation2022

    • Author(s)
      Qu Shili、Nakamura Kentaro
    • Journal Title

      IEICE Electronics Express

      Volume: 19 Issue: 3 Pages: 20210542-20210542

    • DOI

      10.1587/elex.19.20210542

    • NAID

      130008159117

    • ISSN
      1349-2543
    • Year and Date
      2022-02-10
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selection of laser pulse width for efficient generation of photoacoustic signals in liquid-filled thin capillary embedded in soft material2021

    • Author(s)
      Qu Shili、Nakamura Kentaro
    • Journal Title

      AIP Advances

      Volume: 11 Issue: 6 Pages: 065103-065103

    • DOI

      10.1063/5.0048503

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics of megahertz resonant platform for evaluating sensitivity of photoacoustic contrast agent2021

    • Author(s)
      Qu Shili、Nakamura Kentaro
    • Journal Title

      Engineering Research Express

      Volume: 3 Issue: 4 Pages: 045057-045057

    • DOI

      10.1088/2631-8695/ac43c9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Presentation] 半導体レーザを用いた光音響測定による弾性細管の評価2023

    • Author(s)
      王焜, 和田有司, 中村健太郎
    • Organizer
      応用物理学会第68回光波センシング技術研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Directivity of the Photoacoustic Signal Radiated from a Liquid-Filled Thin Elastic Tube2022

    • Author(s)
      Wang Kun, Yuji Wada, Kentaro Nakamura
    • Organizer
      The 43rd Symposium on UltrasSonic Electronics
    • Related Report
      2022 Annual Research Report
  • [Presentation] 液体充填弾性細管の光音響信号の放射指向性2022

    • Author(s)
      王焜, 和田有司, 中村健太郎
    • Organizer
      日本音響学会2022年秋季研究発表会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ガラス管に封じた造影剤試料の光音響試験2022

    • Author(s)
      岩﨑光, 和田有司, 中村健太郎
    • Organizer
      日本音響学会2022年春季研究発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Photoacoustic response of soft tube embedded in phantom2021

    • Author(s)
      Shili Qu, Kentaro Nakamura
    • Organizer
      The 42nd Symposium on UltraSonic Electronics(USE2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pulse duration influence on the photoacoustic temporal waveform of the liquid-filled thin glass capillary embedded in a soft object2020

    • Author(s)
      Shili Qu, Yosuke Mizuno, Kentaro Nakamura
    • Organizer
      IEEE 2020 International Ultrasonics Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Photoacoustic performance and resonance characteristics of the liquid-filled thin glass capillary embedded in a soft material2020

    • Author(s)
      Shili Qu, Kentaro Nakamura
    • Organizer
      The 41st Symposium on Ultrasonic Electronics
    • Related Report
      2020 Annual Research Report
  • [Presentation] Photo-acoustic responses of a liquid-filled thin glass capillary embedded in a soft object2020

    • Author(s)
      Shili Qu, Yosuke Mizuno, Kentaro Nakamura
    • Organizer
      日本音響学会2020年春季研究発表会
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi