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Electrochemical device for cell culture platforms

Research Project

Project/Area Number 18H01840
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 28050:Nano/micro-systems-related
Research InstitutionTohoku University

Principal Investigator

Kosuke Ino  東北大学, 工学研究科, 准教授 (00509739)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords電気化学デバイス / 電極アレイ / 細胞培養 / 細胞機能計測 / 電気化学イメージング / 電気化学 / バイオセンサ / 生体様組織構築 / マイクロ・ナノ化学 / 細胞培養プラットフォーム / 細胞チップ
Outline of Final Research Achievements

For drug screening and toxic testing, experimental animals are used. However, some experiments are banned for animal welfare. In addition, the results differ from those of human, which causes low accuracy of screening. To solve the problems, cultured cells are utilized. However, it is difficult to prepare in-vivo like organs using conventional 2D culture on plastic plates. In addition, it is necessary to monitor cell functions during cell culture for checking the quality of the cells. To solve the problems, in the present study, I have developed electrochemical devices and systems for fabrication and evaluation of 3D cultured cells having in-vivo like functions. For example, an electrode array device was applied for fabrication of 3D hydrogels containing cells. In addition, several analytical devices, such as electrochemiluminescence (ECL)-based devices, were developed. In the future, these devices and systems will be integrated as smart cell culture platforms.

Academic Significance and Societal Importance of the Research Achievements

電気化学デバイス・システムを用いた3Dハイドロゲル作製法は、3D生体様組織構築への応用が期待できる。今回開発した手法は、従来のバイオファブリケーション手法と比べて解像度や使いやすさの面で劣っている。一方、電気化学バイオファブリケーションの研究は発展途上であり、未解明・未達成の部分が多い魅力的な研究分野である。今後の発展で従来法を凌駕できる可能性があり、それによる社会還元が期待できる。これ以外にも本研究では、電気刺激に対する細胞機能制御や新しい原理に基づく電気化学計測法を提案しており、電気化学の細胞チップへの可能性が広がった。今後さらに研究を発展させ、バイオチップ産業にも貢献したい。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (96 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (21 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 19 results,  Open Access: 5 results) Presentation (73 results) (of which Int'l Joint Research: 27 results,  Invited: 10 results)

  • [Int'l Joint Research] CNRS-Universite de Lorraine(フランス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] IBEC(スペイン)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A Droplet Array Device for Electrochemical Detection of Methylene Blue Based on Local Redox Cycling2021

    • Author(s)
      Kaoru Hiramoto, Keika Komatsu, Yuta Yamada, Yuji Nashimoto, Tomokazu Matsue, Kosuke Ino, Hitoshi Shiku
    • Journal Title

      BUNSEKI KAGAKU

      Volume: 70 Issue: 3 Pages: 183-189

    • DOI

      10.2116/bunsekikagaku.70.183

    • NAID

      130008027524

    • ISSN
      0525-1931
    • Year and Date
      2021-03-05
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrochemiluminescence imaging of respiratory activity of cellular spheroids using sequential potential steps2021

    • Author(s)
      Kaoru Hiramoto, Kosuke Ino, Keika Komatsu, Yuji Nashimoto, Hitoshi Shiku
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 181 Pages: 113123-113123

    • DOI

      10.1016/j.bios.2021.113123

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Micropipette-based navigation in a microvascular model for imaging endothelial cell topography using scanning ion conductance microscopy2021

    • Author(s)
      Taira, Noriko, Nashimoto, Yuji, Ino, Kosuke, Ida, Hiroki, Imaizumi, Takuto, Kumatani, Akichika, Takahashi, Yasufumi, Shiku, Hitoshi
    • Journal Title

      Analytical Chemistry

      Volume: 93 Issue: 11 Pages: 4902-4908

    • DOI

      10.1021/acs.analchem.0c05174

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrodeposition of thiolated polymer-based hydrogels via disulfide formation using electrogenerated benzoquinone2021

    • Author(s)
      Kosuke Ino, Ayako Tamura, Kaoru Hiramoto, Mika T. Fukuda, Yuji Nashimoto, Hitoshi Shiku
    • Journal Title

      Chemistry Letters

      Volume: 50 Issue: 2 Pages: 256-259

    • DOI

      10.1246/cl.200732

    • NAID

      130007986388

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of three-dimensional calcium alginate hydrogels using sacrificial templates of sugar2020

    • Author(s)
      Kosuke Ino, Mika T Fukuda, Kaoru Hiramoto, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 130 Pages: 539-544

    • NAID

      40022414302

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxygen consumption rate of tumour spheroids during necrotic-like core formation2020

    • Author(s)
      Rei Mukomoto, Yuji Nashimoto, Takato Terai, Takuto Imaizumi, Kaoru Hiramoto, Kosuke Ino, Ryuji Yokokawa, Takashi Miura, Hitoshi Shiku
    • Journal Title

      Analyst

      Volume: 145 Issue: 19 Pages: 6342-6348

    • DOI

      10.1039/d0an00979b

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrochemical measurement of respiratory activity for evaluation of fibroblast spheroids containing endothelial cell networks2020

    • Author(s)
      Kaoru Hiramoto, Hao-Jen Pai, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku
    • Journal Title

      Electrochimica Acta

      Volume: 340 Pages: 135979-135979

    • DOI

      10.1016/j.electacta.2020.135979

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] バイオファブリケーションによる生体様組織構築2020

    • Author(s)
      伊野浩介
    • Journal Title

      化学と工業

      Volume: 73 Pages: 742-743

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Biofabrication Using Electrochemical Devices and Systems2020

    • Author(s)
      Kosuke Ino, Fumisato Ozawa, Ning Dang, Kaoru Hiramoto, Shodai Hino, Rise Akasaka, Yuji Nashimoto, Hitoshi Shiku
    • Journal Title

      Advanced Biosystems

      Volume: - Issue: 4 Pages: 1900234-1900234

    • DOI

      10.1002/adbi.201900234

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Closed Bipolar Electrode Array for On-Chip Analysis of Cellular Respiration by Cell Aggregates2020

    • Author(s)
      Kosuke Ino, Ryosuke Yaegaki, Kaoru Hiramoto, Yuji Nashimoto, Hitoshi Shiku
    • Journal Title

      ACS Sensors

      Volume: 5 Issue: 3 Pages: 740-745

    • DOI

      10.1021/acssensors.9b02061

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 6.電気化学計測デバイスを用いた細胞の消費物・分泌物評価2019

    • Author(s)
      平本薫、伊野浩介、梨本裕司、珠玖仁
    • Journal Title

      Denki Kagaku

      Volume: 87 Issue: Winter Pages: 323-328

    • DOI

      10.5796/denkikagaku.19-FE0032

    • NAID

      130007759666

    • ISSN
      2433-3255, 2433-3263
    • Year and Date
      2019-12-05
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Differential Electrochemicolor Imaging Using LSI-based Device for Simultaneous Detection of Multiple Analytes2019

    • Author(s)
      Kosuke Ino, Takehiro Onodera, Yuji Nashimoto, Hitoshi Shiku
    • Journal Title

      Sensors and Materials

      Volume: 31 Issue: 1 Pages: 13

    • DOI

      10.18494/SAM.2019.2035

    • ISSN
      0914-4935, 2435-0869
    • Year and Date
      2019-01-15
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrochemical Imaging of Cell Activity in Hydrogels Embedded in Grid-shaped Polycaprolactone Scaffolds Using a Large-scale Integration-based Amperometric Device2019

    • Author(s)
      Kosuke Ino, Yuki Yokokawa, Noriko Taira, Atsushi Suda, Ryota Kunikata, Yuji Nashimoto, Tomokazu Matsue, Hitoshi Shiku
    • Journal Title

      Analytical Sciences

      Volume: 35 Issue: 1 Pages: 39-43

    • DOI

      10.2116/analsci.18SDP01

    • NAID

      130007554915

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2019-01-10
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electric and electrochemical microfluidic devices for cell analysis2019

    • Author(s)
      Kaoru Hiramoto, Kosuke Ino, Yuji Nashimoto, Kentaro Ito, Hitoshi Shiku
    • Journal Title

      Frontiers in Chemistry

      Volume: 7 Pages: 396-396

    • DOI

      10.3389/fchem.2019.00396

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genipin crosslinking of electrodeposited chitosan/gelatin hydrogels for cell culture2019

    • Author(s)
      Ayako Tamura, Kaoru Hiramoto, Kosuke Ino, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku
    • Journal Title

      Chemistry Letters

      Volume: 48 Issue: 10 Pages: 1178-1180

    • DOI

      10.1246/cl.190466

    • NAID

      130007724095

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination of double-mediator system with large-scale integration-based amperometric devices for detecting NAD(P)H:quinone oxidoreductase 1 activity of cancer cell aggregates2019

    • Author(s)
      Kosuke Ino, Takehiro Onodera, Mika T. Fukuda, Yuji Nashimoto, Hitoshi Shiku
    • Journal Title

      ACS Sensors

      Volume: - Issue: 6 Pages: 1619-1625

    • DOI

      10.1021/acssensors.9b00344

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrodeposition-based rapid bioprinting of 3D-designed hydrogels with a pin art device2019

    • Author(s)
      Noriko Taira, Kosuke Ino, Hiroki Ida, Yuji Nashimoto, Hitoshi Shiku
    • Journal Title

      Biofabrication

      Volume: - Issue: 3 Pages: 035018-035018

    • DOI

      10.1088/1758-5090/ab166e

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrochemical fabrication of fibrin gels via cascade reaction for cell culture2019

    • Author(s)
      Noriko Taira, Kosuke Ino, Tatsuki Kumagai, Yuji Nashimoto, Hitoshi Shiku
    • Journal Title

      Chemical Communications

      Volume: - Issue: 37 Pages: 5335-5338

    • DOI

      10.1039/c9cc01576k

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogel electrodeposition based on bipolar electrochemistry2018

    • Author(s)
      Kosuke Ino, Tomoaki Matsumoto, Noriko Taira, Tatsuki Kumagai, Yuji Nashimoto, Hitoshi Shiku
    • Journal Title

      Lab on a Chip

      Volume: 18 Issue: 16 Pages: 2425-2432

    • DOI

      10.1039/c8lc00465j

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular electrochemical sensing2018

    • Author(s)
      Kosuke Ino, Yuji Nashimoto, Noriko Taira, Javier Ramon Azcon, Hitoshi Shiku
    • Journal Title

      Electroanalysis

      Volume: 30 Issue: 10 Pages: 2195-2209

    • DOI

      10.1002/elan.201800410

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Local hydrogel fabrication based on electrodeposition with a large-scale integration (LSI)-based amperometric device2018

    • Author(s)
      Kosuke Ino, Mayuko Terauchi, Mai Gakumasawa, Noriko Taira, Atsushi Suda, Ryota Kunikata, Tomokazu Matsue, Hitoshi Shiku
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 277 Pages: 95-101

    • DOI

      10.1016/j.snb.2018.08.135

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Integrated electrochemical devices for evaluation of three-dimensional cultured cells2021

    • Author(s)
      Kosuke Ino
    • Organizer
      Pittcon 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Potential step electrochemiluminescence imaging of cellular activity of living spheroids2021

    • Author(s)
      Kaoru Hiramoto, Kosuke Ino, Keika Komatsu, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      Pittcon 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ハイスループットアッセイに向けたスフェロイド呼吸活性の電気化学発光イメージング2021

    • Author(s)
      平本薫、伊野浩介、小松慶佳、梨本裕司、珠玖仁
    • Organizer
      iACEシンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 電気化学に基づくハイドロゲル形成と細胞培養への応用2021

    • Author(s)
      伊野浩介
    • Organizer
      電気化学会第88回大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 微小バイポーラ電極アレイを用いた非ECL利用型システムの構築とその電気化学的な特性評価2021

    • Author(s)
      赤坂理世、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      電気化学会第88回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 3次元培養細胞の代謝活性計測に向けた電気化学発光システムの開発2021

    • Author(s)
      小松慶佳、平本薫、梨本裕司、伊野浩介、珠玖仁
    • Organizer
      電気化学会第88回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 電気化学的呼吸測定法による血管様構造を有するスフェロイドの薬効評価2020

    • Author(s)
      平本薫、白皓仁、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      第80回分析化学討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Detection of exosomes from cell spheroid using aptamer-based electrode-array-device2020

    • Author(s)
      Liana Mohd Zulkifly、平本薫、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      第80回分析化学討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effect of endothelial cell networks on respiratory activity of spheroids2020

    • Author(s)
      Kaoru Hiramoto, Hao-Jen Pai, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      71st Annual ISE Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Permeability assay of cells using LSI devices2020

    • Author(s)
      Hao-Jen Pai, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      日本分析化学会第69年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Evaluation of vascular perfusability based on ion currents in microfluidic devices2020

    • Author(s)
      Rise Akasaka, Kosuke Ino, Masashi Ozawa, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      化学系学協会東北大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Cell analysis using integrated electrochemical devices2020

    • Author(s)
      Kosuke Ino
    • Organizer
      PRiME 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] チオール修飾ポリエチレングリコールを用いたハイドロゲルの電解析出2020

    • Author(s)
      田村綾子、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      化学とマイクロ・ナノシステム学会 第42回研究会(Cheminas42)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 電気化学発光による3次元培養細胞の代謝物測定法の開発2020

    • Author(s)
      小松慶佳、平本薫、梨本裕司、伊野浩介、珠玖仁
    • Organizer
      化学とマイクロ・ナノシステム学会 第42回研究会(Cheminas42)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Electrochemiluminescence measurement of cell-spheroid secretions using H2O2/luminol2020

    • Author(s)
      Liana Mohd Zulkifly、平本薫、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      第51回セミコンファレンス・第33回東北若手の会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 培養細胞の評価を可能にする電気化学微小流路デバイス・システム2020

    • Author(s)
      伊野浩介
    • Organizer
      第30回 日本MRS年次大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Electrochemiluminescence imaging of cell spheroid and its ex vivo microenvironment2020

    • Author(s)
      平本薫、伊野浩介、小松慶佳、梨本裕司、珠玖仁
    • Organizer
      第30回 日本MRS年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 電気化学発光を用いた細胞スフェロイドの代謝活性検出2020

    • Author(s)
      平本薫、伊野浩介、小松慶佳、梨本裕司、珠玖仁
    • Organizer
      生体コモンスペース研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 電気化学デバイスを用いた3次元培養細胞の評価とバイオファブリケーション2020

    • Author(s)
      伊野浩介
    • Organizer
      日本化学会 第100春季年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 細胞培養での電気刺激による血管網形成の誘導2020

    • Author(s)
      伊野浩介、日野翔太、梨本裕司、珠玖仁
    • Organizer
      電気化学会第87回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Electrochemical imaging using redox mediators for cell activity of three-dimensional cultured cells2019

    • Author(s)
      Kosuke Ino, Takehiro Onodera, Mika T. Fukuda, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      SPIE
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rapid electrodeposition-based hydrogel printing system2019

    • Author(s)
      Noriko Taira, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      11th International Symposium on Microchemistry and Microsystem
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 電解析出を利用した短時間でプリント可能な電気化学ハイドロゲルプリンティング法の開発2019

    • Author(s)
      平典子、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      化学とマイクロ・ナノシステム学会第39回研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Large scale integration-based electrochemical device for respiration assay of co-cultured cell spheroids2019

    • Author(s)
      Pai Hao-Jen, Kosuke Ino, Yuji Nashimoto and Hitoshi Shiku
    • Organizer
      The 3rd ECS Yamagata University Student Chapter Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrochemical analysis of three-dimensional cultured cells using bipolar array devices2019

    • Author(s)
      Kosuke Ino, Ryosuke Yaegaki, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      70th Annual Meeting of the International Society of Electrochemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrodeposition of 3D hydrogels using 3D electrode arrays in applications of cell culture2019

    • Author(s)
      Kosuke Ino, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      70th Annual Meeting of the International Society of Electrochemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrochemical hydrogel prinitng system with a pin art device2019

    • Author(s)
      Noriko Taira , Kosuke Ino , Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      International Symposium on Analytical Electrochemistry 2019 (ISAE 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrochemical gel formation by controlling enzyme activity for cell culture2019

    • Author(s)
      Tatsuki Kumagai, Kosuke Ino, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      International Symposium on Analytical Electrochemistry 2019 (ISAE 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrochemical patterning of hydrogel for cell culture2019

    • Author(s)
      Ayako Tamura, Kosuke Ino, Kaoru Hiramoto, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      International Symposium on Analytical Electrochemistry 2019 (ISAE 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Large-scale integration-based electrochemical device for respiration assay of co-culture cell spheroids2019

    • Author(s)
      Hao-Jen Pai, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      International Symposium on Analytical Electrochemistry 2019 (ISAE 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrodeposition-based hydrogel printing system with a pin art device2019

    • Author(s)
      Noriko Taira, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      Tohoku University's Chemistry Summer School 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 電気化学デバイスを用いた血管内皮細胞の機能制御2019

    • Author(s)
      日野翔太、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      第13回バイオ関連化学シンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 酵素活性制御を用いたフィブリンゲルの電解析出と細胞培養2019

    • Author(s)
      熊谷 樹、伊野 浩介、平 典子、梨本 裕司、珠玖 仁
    • Organizer
      第13回バイオ関連化学シンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞培養に向けたハイドロゲルの電解析出2019

    • Author(s)
      田村 綾子、平本薫、伊野浩介、平典子、梨本裕司、珠玖仁
    • Organizer
      第13回バイオ関連化学シンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] がん細胞エクソソームの検出に向けた電気化学アプタセンサ2019

    • Author(s)
      Liana Mohd Zulkifly, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      第13回バイオ関連化学シンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 微小電極集積デバイスを用いた細胞機能の解析2019

    • Author(s)
      白皓仁、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      第13回バイオ関連化学シンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] バイポーラ電気化学デバイスを用いた細胞活性評価2019

    • Author(s)
      伊野浩介、八重垣稜佑、梨本裕司、珠玖仁
    • Organizer
      日本分析化学会 第68年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Electrochemical patterning of biocompatible hydrogels for cell culture2019

    • Author(s)
      Ayako Tamura, Kaoru Hiramoto, Kosuke Ino, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      2019年度化学系学協会東北大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of an electrochemical aptasensor for detection of cancerous exosomes2019

    • Author(s)
      Liana Mohd Zulkifly, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      2019年度化学系学協会東北大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Electrochemical hydrogel printing for cell culture using integrated devices2019

    • Author(s)
      Kosuke Ino
    • Organizer
      The 10th International Workshop on Scanning Electrochemical Microscopy (SECM10)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 電気化学デバイスを用いた血管内皮細胞の管形成能制御2019

    • Author(s)
      日野翔太、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      化学とマイクロ・ナノシステム学会 第40回研究会(40th CHEMINAS)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Electrochemical reaction for hydrogel fabrication2019

    • Author(s)
      Tatsuki Kumagai, Kosuke Ino, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      2019 International Symposium on Chemical-Environmental-Biomedical Technology (isCEBT 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-time sensing of endothelial cell barrier function by using a large-scale integration device2019

    • Author(s)
      Hao-Jen Pai, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      2019 International Symposium on Chemical-Environmental-Biomedical Technology (isCEBT 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 3次元環境における血管新生および管形成への電気刺激の影響2019

    • Author(s)
      赤坂理世、伊野浩介、日野翔太、梨本裕司、珠玖仁
    • Organizer
      第50回セミコンファレンス、第32回東北若手の会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Electrodeposition of patterned hydrogels using an LSI-based electrochemical devices for biosensing and cell culture2018

    • Author(s)
      Kosuke Ino, Mayuko Terauchi, Mai Gakumasawa, Hitoshi Shiku
    • Organizer
      22nd Topical Meeting of the International Society of Electrochemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Respiration assay of co-culture cell spheroid using an LSI-based electrochemical device2018

    • Author(s)
      Hao-Jen Pai, Takehiro Onodera, Kosuke Ino, Hitoshi Shiku
    • Organizer
      22nd Topical Meeting of the International Society of Electrochemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体組織構築に向けた電気化学3Dハイドロゲルプリンティング2018

    • Author(s)
      平典子、伊野浩介、珠玖仁
    • Organizer
      化学とマイクロ・ナノシステム学会 第37回研究会(37th CHEMINAS)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Electrochemical hydrogel printing for cell culture2018

    • Author(s)
      Noriko Taira, Kosuke Ino, Hitoshi Shiku
    • Organizer
      The 10th International Symposium on Microchemistry and Microsystems
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 電気化学ハイドロゲルプリンティングによる細胞足場構築と電解析出の影響評価2018

    • Author(s)
      平典子、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      東日本分析若手交流会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 微小電極集積デバイスを用いた細胞分化における酵素活性と代謝活性の同時イメージング2018

    • Author(s)
      小野寺岳大、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      第6回細胞凝集研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] クローズドバイポーラ電極を用いた電気化学発光による細胞の呼吸活性の評価2018

    • Author(s)
      八重垣稜佑、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      第6回細胞凝集研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 電気化学ハイドロゲルプリンティングの開発2018

    • Author(s)
      平典子、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      第6回細胞凝集研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Electrochemical 3D hydrogel scaffold printing2018

    • Author(s)
      Noriko Taira, Kosuke Ino, Hitoshi Shiku
    • Organizer
      H30 Tohoku University's Chemistry Summer School 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hydrogel fabrication on bipolar electrodes2018

    • Author(s)
      Kosuke Ino, Tomoaki Matsumoto, Hitoshi Shiku
    • Organizer
      69th Annual Meeting of the International Society of Electrochemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrochemicolor imaging for simultaneous detection of multiple analytes using large scale integration (LSI) devices2018

    • Author(s)
      Kosuke Ino, Takehiro Onodera, Mayuko Terauchi, Hitoshi Shiku
    • Organizer
      69th Annual Meeting of the International Society of Electrochemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrodeposition of calcium alginate/gelatin hydrogels by scanning or stamping an electrode for cell culture platforms2018

    • Author(s)
      Jordan Robert, Kosuke Ino, Noriko Taira, Hitoshi Shiku
    • Organizer
      69th Annual Meeting of the International Society of Electrochemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simultaneous imaging of enzyme and respiration activities of cell aggregates using an electrode array device2018

    • Author(s)
      Takehiro Onodera, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      International Symposium on Chemical-Enviromental-Biomedical Technology (isCEBT2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrochemiluminescence detection for cellular respiratory activity using closed bipolar electrodes2018

    • Author(s)
      Ryosuke Yaegaki, Kosuke Ino,Yuji Nashimoto, and Hitoshi Shiku
    • Organizer
      International Symposium on Chemical-Enviromental-Biomedical Technology (isCEBT2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 電気化学デバイスを用いたハイドロゲルの電解析出2018

    • Author(s)
      伊野浩介、平典子、珠玖仁
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Electrochemical devices for evaluation of three-dimensional cultured cells2018

    • Author(s)
      Kosuke Ino, Hitoshi Shiku
    • Organizer
      4th Asian Symposium for Analytical Sciences
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 電気化学を用いて生成した生体適合性ハイドロゲルの機能評価2018

    • Author(s)
      熊谷樹、伊野浩介、松本知明、平典子、梨本裕司、珠玖仁
    • Organizer
      日本分析化学会第67年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 微小電極集積デバイスを用いた幹細胞の酵素活性と代謝活性の同時測定2018

    • Author(s)
      小野寺岳大、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      日本分析化学会第67年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 電気化学ハイドロゲルプリンティングにより構築した細胞足場内での細胞培養評価2018

    • Author(s)
      平典子、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      日本分析化学会第67年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] クローズドバイポーラ電極を用いた電気化学発光による細胞呼吸活性の評価2018

    • Author(s)
      八重垣稜佑、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      日本分析化学会第67年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Electrochemical formation of biocompatible hydrogels for cell culture2018

    • Author(s)
      Tatsuki Kumagai, Kosuke Ino, Tomoaki Matsumoto, NorikoTaira, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      平成30年度化学系学協会東北大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Vascular network formation on electrochemical devices2018

    • Author(s)
      Syoudai Hino, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku
    • Organizer
      平成30年度化学系学協会東北大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 電気化学デバイスを用いたハイドロゲル電解析出と細胞培養への応用2018

    • Author(s)
      伊野浩介、平典子、梨本裕司、珠玖仁
    • Organizer
      2018年電気化学秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 電気化学デバイス上での血管内皮細胞培養2018

    • Author(s)
      日野翔太、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      化学とマイクロ・ナノシステム学会 第38回研究会(38th CHEMINAS)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Electrochemical detection in micro/nano-systems:from cell analysis to characterization of energy materials2018

    • Author(s)
      Kosuke Ino
    • Organizer
      Workshop in MicroTAS 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞足場パターニングのための電気化学ハイドロゲルプリント手法の開発2018

    • Author(s)
      平典子、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      第49回セミコンファレンス、第31回東北若手の会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 集積電気化学デバイスを用いたバイオ応用2018

    • Author(s)
      伊野浩介
    • Organizer
      第27回日本MRS年次大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Evaluation of intracellular enzyme activity of cell aggregates using an LSI-based electrochemical device2018

    • Author(s)
      小野寺岳大、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      第28回日本MRS年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Measurement of cellular respiratory activity by electrochemiluminescence using C-BPEs2018

    • Author(s)
      八重垣稜佑、伊野浩介、梨本裕司、珠玖仁
    • Organizer
      第28回日本MRS年次大会
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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