|Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
|Outline of Final Research Achievements
Conventional drug delivery systems deliver drug-encapsulated particles to a disease site. However, side effects and decreased efficacy associated with drug leakage from the carriers are a problem. Therefore, new therapeutic strategies that are safe and highly therapeutic efficacy are required. This research was conducted with the aim of creating nanodevices that synthesize drugs locally without the need for anticancer drugs or other drugs. As the result, the following were clarified: Development of the polymer vesicle which shows the molecular permeability under specific biological environment, elucidation of the molecular permeation mechanism, molecular design guideline necessary for the molecular permeation, etc.. Furthermore, it has been found that a polymeric vesicle device encapsulating an enzyme can function and kill cancer cells even under a cell culture environment.