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Development of metal-responsive DNA supramolecules based on enzymatic DNA synthesis

Research Project

Project/Area Number 18H02081
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 37010:Bio-related chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

Takezawa Yusuke  東京大学, 大学院理学系研究科(理学部), 助教 (70508598)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
KeywordsDNA / 人工DNA / DNAポリメラーゼ / DNAリガーゼ / DNAzyme / DNAナノテクノロジー / 金属錯体型塩基対 / 超分子化学 / デオキシリボザイム / 核酸化学 / 金属錯体 / 酵素反応 / 金属錯体型人工塩基対 / DNA合成酵素
Outline of Final Research Achievements

We have developed facile enzymatic methods to synthesize DNA strands containing a ligand-type hydroxypyridone (H) nucleotide, which forms a Cu(II)-mediated base pair (H-Cu(II)-H). The H-modified oligonucleotides were synthesized by a primer extension reaction using two DNA polymerases or by a two-step reaction with polymerases and ligases. The enzymatic synthesis was subsequently applied to the development of metal-responsive allosteric DNAzymes, whose catalytic activity can be regulated by the formation of metal-mediated base pairs. The rational design strategy and the easy enzymatic synthesis established in this study provide a versatile way to develop a variety of metal-responsive DNA materials based on metal-mediated artificial base pairing.

Academic Significance and Societal Importance of the Research Achievements

本研究では、DNA合成酵素を用いた金属配位子型人工DNAの酵素合成法の開発と、それに基づく金属イオン応答性DNAzymeの開発を行った。金属応答性DNA鎖の簡便な合成が可能になった点、および既存の機能性核酸を基に配列を合理設計できる点が特長であり、他の機能性核酸やDNAナノ構造体の構造・機能制御へも応用できる成果である。特に一対の非天然塩基対の導入のみで活性制御が可能となり、最小限の修飾・改変による核酸の機能化という点で大きな意義がある。生体微量金属を含む種々の金属イオンに応答する機能性核酸も創出できると考えられ、DNAナノテクノロジーや生命金属科学の基礎分子技術としての波及効果も期待される。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (68 results)

All 2022 2021 2020 2019 2018

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (58 results) (of which Int'l Joint Research: 15 results) Book (2 results)

  • [Journal Article] Site-Specific Polymerase Incorporation of Consecutive Ligand-Containing Nucleotides for Multiple Metal-Mediated Base Pairing2021

    • Author(s)
      T. Nakama, Y. Takezawa, M. Shionoya
    • Journal Title

      Chemical Communications

      Volume: 57 Issue: 11 Pages: 1392-1395

    • DOI

      10.1039/d0cc07771b

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metal-responsive Reversible Binding of Triplex-forming Oligonucleotides with 5-Hydroxyuracil Nucleobases2021

    • Author(s)
      K. Nishiyama, K. Mori, Y. Takezawa, M. Shionoya
    • Journal Title

      Chemical Communications

      Volume: 57 Issue: 20 Pages: 2487-2490

    • DOI

      10.1039/d1cc00553g

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bipyridine-Modified DNA Three-Way Junctions with Amide Linkers: Metal-Dependent Structure Induction and Self-Sorting2021

    • Author(s)
      Y. Takezawa, S. Sakakibara, M. Shionoya
    • Journal Title

      Chem. Eur. J.

      Volume: 67 Issue: 67 Pages: 16626-16633

    • DOI

      10.1002/chem.202102977

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allosteric Regulation of DNAzyme Activities through Intrastrand Transformation Induced by Cu(II)-Mediated Artificial Base Paring2020

    • Author(s)
      T. Nakama, Y. Takezawa, D. Sasaki, M. Shionoya
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 22 Pages: 10153-10162

    • DOI

      10.1021/jacs.0c03129

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sharp Switching of DNAzyme Activity through the Formation of a Cu(II)-mediated Carboxyimidazole Base Pair2020

    • Author(s)
      Y. Takezawa, L. Hu, T. Nakama, M. Shionoya
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 48 Pages: 21488-21492

    • DOI

      10.1002/anie.202009579

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Metal-Dependent DNA Base Pairing of 5-Carboxyuracil with Itself and All Four Canonical Nucleobases2020

    • Author(s)
      Y. Takezawa, A. Suzuki, M. Nakaya, K. Nishiyama, M. Shionoya
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 52 Pages: 21640-21644

    • DOI

      10.1021/jacs.0c11437

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Supramolecular DNA Three-way Junction Motifs with a Bridging Metal Center2020

    • Author(s)
      Y. Takezawa, M. Shionoya
    • Journal Title

      Frontiers in Chemistry

      Volume: 7 Pages: 925-925

    • DOI

      10.3389/fchem.2019.00925

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enzymatic Synthesis of Cu(II)-responsive Deoxyribozymes through Polymerase Incorporation of Artificial Ligand-type Nucleotides2019

    • Author(s)
      Y. Takezawa, T. Nakama, M. Shionoya
    • Journal Title

      Journal of the American Chemical Society

      Volume: 141 Issue: 49 Pages: 19342-19350

    • DOI

      10.1021/jacs.9b08955

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] 塩基除去修復酵素を用いたフェナントロリン配位子修飾DNA三叉路分岐構造の合成2022

    • Author(s)
      櫻井 航平・竹澤 悠典・塩谷 光彦
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Cu(II)-mediated stabilization of DNA duplexes having different numbers of 1,N6-ethenoadenine lesions as metal binding sites2022

    • Author(s)
      Silpa Chandran Rajasree, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 金属錯体型人工DNAの構築を目指したDNAポリメラーゼによるエテノアデノシンの連続導入2022

    • Author(s)
      若野 将大・Silpa Chandran Rajasree・竹澤 悠典・塩谷 光彦
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Rational Design of Metal-responsive Allosteric DNAzymes2021

    • Author(s)
      Yusuke Takezawa
    • Organizer
      日本化学会 第101春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Metal-dependent Stabilization of DNA Duplexes Containing 2-Oxoimidazole-carboxylate/carboxamide as Nucleobases2021

    • Author(s)
      Lingyun Hu, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      日本化学会 第101春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] DNA-based Molecular Switches Driven by Metal Complexation of 5-Hydroxyuracil Nucleobases2021

    • Author(s)
      Keita Mori, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      日本化学会 第101春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] DNA-templated Assembly of Cu(II) Ions using 1,N6-Ethenoadenosine nucleobases as Metal Binding Sites2021

    • Author(s)
      Silpa Chandran Rajasree, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      日本化学会 第101春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒドロキシウラシルを用いた金属イオン応答性アロステリックDNAzymeの開発2021

    • Author(s)
      竹澤 悠典・黄 薇恩・森 圭太・西山 康太郎・塩谷 光彦
    • Organizer
      第18回ホスト-ゲスト・超分子化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 5-ヒドロキシウラシルの金属錯体形成に基づくDNA分子ピンセットの開閉の繰り返し制御2021

    • Author(s)
      森 圭太・竹澤 悠典・塩谷 光彦
    • Organizer
      第18回ホスト-ゲスト・超分子化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 金属配位に基づく5-カルボキシウラシルの塩基対スイッチング2021

    • Author(s)
      竹澤 悠典・張 晗辞・鈴木 暁・森 圭太・胡 凌雲・塩谷 光彦
    • Organizer
      第15回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Metal-dependent activity regulation of a compact-sized DNAzyme containing an imidazole-4-carboxylate base pair2021

    • Author(s)
      Lingyun Hu, Yusuke Takezawa, Takahiro Nakama, Mitsuhiko Shionoya
    • Organizer
      第15回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Metal-Mediated Stabilization of DNA Three-Way Branched Structures Modified with Phenanthroline Ligands2021

    • Author(s)
      Yusuke Takezawa, Daisuke Kanemaru, Mitsuhiko Shionoya
    • Organizer
      錯体化学会第71回討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Cu(II)-Dependent Stabilization of DNA Duplexes Bearing Consecutive 1,N6-Ethenoadenosine Lesions2021

    • Author(s)
      Silpa Chandran Rajasree, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      錯体化学会第71回討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of Metal-responsive DNAzymes using 5-Carboxyuracils as Metal Binding Sites2021

    • Author(s)
      Hanci Zhang, Yusuke Takezawa, Lingyun Hu, Mitsuhiko Shionoya
    • Organizer
      錯体化学会第71回討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 金属イオンの結合により活性を制御できる化学修飾DNAzyme の開発2021

    • Author(s)
      竹澤 悠典・中間 貴寛・胡 凌雲・塩谷 光彦
    • Organizer
      第5回分子ロボティクス年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of an AND-gate DNAzyme that responds to Cu(II) and Ag(I) ions as inputs2021

    • Author(s)
      Yusuke Takezawa, Takahiro Nakama, Mitsuhiko Shionoya
    • Organizer
      The 48th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reversible Binding of Triplex-forming Oligonucleotides Based on Metal Complexation of 5-Hydroxyuracil Nucleobases2021

    • Author(s)
      Keita Mori, Kotaro Nishiyama, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      The 48th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metal-Dependent Regulation of DNAzyme Activities by using Cu(II)-Mediated Artificial Base Pairing2021

    • Author(s)
      Yusuke Takezawa, Takahiro Nakama, Mitsuhiko Shionoya
    • Organizer
      Pacifichem 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Metal-Responsive DNA Tweezers based on Coordination-Driven Switching of 5-Hydroxyuracil Nucleobases2021

    • Author(s)
      Keita Mori, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      Pacifichem 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cu(II)-Responsive Allosteric DNAzymes Regulated through Intrastrand Transformation by Metal-Mediated Artificial Base Paring2021

    • Author(s)
      Takahiro Nakama, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      Pacifichem 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cu(II)-Specific Regulation of DNAzyme Function by Metal-Mediated Base Paring of Nucleotides with a Carboxyimidazole Base2021

    • Author(s)
      Lingyun Hu, Takahiro Nakama, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      Pacifichem 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒドロキシウラシルの塩基対スイッチングに基づく金属イオン応答性DNA超分子の創製2020

    • Author(s)
      竹澤 悠典・森 圭太・黄 薇恩・西山 康太郎・塩谷 光彦
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 金属錯体型塩基対を用いた8-17 DNAzymeのRNA切断活性制御2020

    • Author(s)
      胡 凌雲・中間 貴寛・竹澤 悠典・塩谷 光彦
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Metal-dependent Base Pairing of 5-Carboxyuracil with Natural Nucleobases within DNA Duplexes2020

    • Author(s)
      Yusuke Takezawa, Akira Suzuki, Keita Mori, Manabu Nakaya, Kotaro Nishiyama, Mitsuhiko Shionoya
    • Organizer
      錯体化学会 第70回討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of Metal-responsive DNA Tweezers Based on Metal Complexation of 5-Hydroxyuracil Nucleobases2020

    • Author(s)
      Keita Mori, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      錯体化学会 第70回討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Cu(II)-mediated imidazole-4-carboxylate homo base pair as a switch for controlling the catalytic activity of a DNAzyme2020

    • Author(s)
      Lingyun Hu, Yusuke Takezawa, Takahiro Nakama, Mitsuhiko Shionoya
    • Organizer
      第20回東京大学 生命科学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Allosteric Regulation of Single-stranded DNAzymes Based on Cu(II)-mediated Artificial Base Pairing2020

    • Author(s)
      Takahiro Nakama, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cu(II)-specific Activation of Synthetic DNAzymes Possessing a Pair of 4-Carboxyimidazole-bearing Nucleotides2020

    • Author(s)
      Lingyun Hu, Takahiro Nakama, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Chiral Assembly of Cu(II)-Complexes within Glycol Nucleic Acids2020

    • Author(s)
      Jens Christian Leon, Yusuke Takezawa, Manabu Nakaya,Mitsuhiko Shionoya
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Coordination-driven Base-pair Switching of 5-Hydroxyuracil Nucleobases towards Development of Metal-responsive DNA Tweezers2020

    • Author(s)
      Keita Mori, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Encapsulation of luminescent Pt(II) complexes by DNA duplexes containing abasic sites2020

    • Author(s)
      Manabu Nakaya, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of Metal-responsive RNA-cleaving DNAzymes: Allosteric Regulation of the Catalytic Activity through Formation of a Cu(II)-mediated Artificial Base Pair2019

    • Author(s)
      中間 貴寛・竹澤 悠典・塩谷 光彦
    • Organizer
      第19回 東京大学 生命科学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cu(II)錯体型人工核酸塩基対を用いた一本鎖DNAzymeの活性制御2019

    • Author(s)
      竹澤 悠典・中間 貴寛・胡 凌雲・塩谷 光彦
    • Organizer
      第17回ホスト-ゲスト・超分子化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] イミダゾール-4-カルボン酸-銅(II)錯体型人工塩基対を用いた金属イオン応答性DNAzymeの構築2019

    • Author(s)
      胡 凌雲・中間 貴寛・竹澤 悠典・塩谷 光彦
    • Organizer
      第17回ホスト-ゲスト・超分子化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cu(II)-responsive Split DNAzymes with Metal-mediated Artificial Base Pairs2019

    • Author(s)
      Yusuke Takezawa, Takahiro Nakama, Lingyun Hu, Mitsuhiko Shionoya
    • Organizer
      15th International Symposium on Applied Bioinorganic Chemistry (ISABC2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metal-dependent Regulation of Hybridization Behaviors of DNA Strands Containing 5-Hydroxyuracil Bases at the Terminus2019

    • Author(s)
      Keita Mori, Kotaro Nishiyama, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      15th International Symposium on Applied Bioinorganic Chemistry (ISABC2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enzymatic Synthesis of Ligand-bearing DNA using Polymerase and Ligase toward Development of Cu(II)-responsive DNAzymes2019

    • Author(s)
      Takahiro Nakama, Yusuke Takezawa, Daisuke Sasaki, Mitsuhiko Shionoya
    • Organizer
      15th International Symposium on Applied Bioinorganic Chemistry (ISABC2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cu(II)-induced Stabilization and Destabilization of DNA Duplexes Containing 5-Carboxyuracil Nucleobases2019

    • Author(s)
      Yusuke Takezawa, Akira Suzuki, Manabu Nakaya, Kotaro Nishiyama, Mitsuhiko Shionoya
    • Organizer
      Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Split and Non-split DNAzymes Containing a Cu(II)-mediated Artificial Base Pair: Metal-dependent Regulation of the RNA-cleaving Activity2019

    • Author(s)
      Takahiro Nakama, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 金属配位子型人工核酸塩基の導入によるCu(II)イオン応答性DNAzymeの合理設計2019

    • Author(s)
      竹澤 悠典・中間 貴寛・胡 凌雲・塩谷 光彦
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 5-ヒドロキシウラシルの金属錯体形成に基づくDNA鎖交換反応:修飾塩基の導入数の検討2019

    • Author(s)
      森 圭太・竹澤 悠典・塩谷 光彦
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of Cu(II)-responsive DNAzymes by Introducing a Metal-mediated Artificial Base Pair2019

    • Author(s)
      Yusuke Takezawa
    • Organizer
      10th RSC-CSJ Joint Symposium: Chemistry for Complex Biological Systems
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reversible Regulation of DNAzyme Activity through Cu(II)-mediated Base Pairing with Carboxyimidazole Nucleobases2019

    • Author(s)
      Lingyun Hu, Takahiro Nakama, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      錯体化学会 第69回討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Metal-mediated Structure Coversion and Self-sorting of Bipyridine-modified DNA Three-way Junctions2019

    • Author(s)
      Yusuke Takezawa, Shiori Sakakibara, Daisuke Kanemaru, Mitsuhiko Shionoya
    • Organizer
      The 46th International Symposium on Nucleic Acids Chemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metal-dependent regulation of DNA duplex stability based on the metal complexation of 5-carboxyuracil nucleobases2019

    • Author(s)
      Yusuke Takezawa, Akira Suzuki, Manabu Nakaya, Mitsuhiko Shionoya
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 5-ヒドロキシウラシル塩基の金属錯体形成を駆動力とした可逆なDNA鎖交換反応2019

    • Author(s)
      森 圭太・西山 康太郎・竹澤 悠典・塩谷 光彦
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Metal-dependent orthogonal regulation of DNAzyme activities by the formation of Cu(II)- and Hg(II)-mediated base pairs2019

    • Author(s)
      Takahiro Nakama, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Encapsulation of mononuclear Ni(II) salen-type complexes in an abasic site in DNA duplexes2019

    • Author(s)
      Manabu Nakaya, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Construction of DNA three-way junction structures containing thiol ligands at the junction core2019

    • Author(s)
      Nobuyuki Fuse, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Ni(II)-ビピリジン錯体でクロスリンクされた三叉路型DNA超分子の構築:配位子-DNA間のリンカーの構造比較2018

    • Author(s)
      竹澤 悠典・榊原 志織・米田 周平・デュプレー ジャン-ルイ・中間 貴寛・塩谷 光彦
    • Organizer
      第16回ホスト-ゲスト・超分子化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 金属イオン応答性DNAzymeの開発: Cu(II)錯体型人工塩基対を用いた触媒活性の繰返し制御2018

    • Author(s)
      中間 貴寛・竹澤 悠典・塩谷 光彦
    • Organizer
      第16回ホスト-ゲスト・超分子化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Metal-dependent Thermal Stabilization of DNA Duplexes containing 5-Carboxyuracil Nucleobases2018

    • Author(s)
      Yusuke Takezawa, Akira Suzuki, Kotaro Nishiyama, Mitsuhiko Shionoya
    • Organizer
      錯体化学会第68回討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cu(II)-specific Activation of DNAzyme utilizing Metal-mediated Artificial Base Pairing2018

    • Author(s)
      Takahiro Nakama, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      錯体化学会第68回討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 5-ヒドロキシウラシル塩基の金属錯体形成に基づくDNA 二重鎖の熱的安定化:修飾塩基の導入位置の検討2018

    • Author(s)
      森 圭太・西山 康太郎・竹澤 悠典・塩谷 光彦
    • Organizer
      錯体化学会第68回討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Construction of Metallo-DNA Duplexes by Using 5-Substituted Uracil Nucleobases as Metal Ligands2018

    • Author(s)
      Yusuke Takezawa, Kotaro Nishiyama, Akira Suzuki, Mitsuhiko Shionoya
    • Organizer
      The 43rd International Conference on Coordination Chemistry (ICCC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Metal-responsive DNAzyme through Incorporation of a Cu(II)-mediated Artificial Base Pair2018

    • Author(s)
      Takahiro Nakama, Yusuke Takezawa, Mitsuhiko Shionoya
    • Organizer
      The 43rd International Conference on Coordination Chemistry (ICCC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 5-カルボキシウラシル塩基のCu(II)錯体形成によるDNA二重鎖安定化:修飾塩基の導入数の効果2018

    • Author(s)
      仲谷 学・鈴木 暁・竹澤 悠典・塩谷 光彦
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 5-ヒドロキシウラシル塩基を末端に有するDNA鎖を用いた金属配位駆動型DNA鎖交換反応の開発2018

    • Author(s)
      森 圭太・西山 康太郎・竹澤 悠典・塩谷 光彦
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Book] 核酸科学ハンドブック (第3章 分析・無機化学 3.4 核酸無機材料)2020

    • Author(s)
      竹澤 悠典・中間 貴寛・塩谷 光彦 (日本核酸化学会 監修)
    • Total Pages
      9
    • Publisher
      講談社サイエンティフィク
    • ISBN
      9784065207864
    • Related Report
      2020 Annual Research Report
  • [Book] 錯体化合物事典2019

    • Author(s)
      錯体化学会
    • Total Pages
      1000
    • Publisher
      朝倉書店
    • ISBN
      9784254141054
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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