| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Outline of Final Research Achievements |
Middle-sized natural products (M.W. 500 to 2000) such as oligosaccharides, cyclic peptides, macrolides, and other metabolites are promising drug candidates beyond Lipinski’s rule of 5. Because middle-sized molecules target, for example, protein-protein interactions more efficiently than small molecules do, a large number of such drugs have been approved and under development in recent years. For the exploration of such natural products and their synthetic derivatives, their structural elucidation is one of the major bottlenecks as they possess multiple chiral centers. In this work, we developed new methods for structural analysis of middle-sized molecules by using vibrational circular dichroism (VCD) spectroscopy. Furthermore, this work achieved the first preparation of carbodiimides with one-handed axial chirality.
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