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Search for small molecules controlling cell differentiation

Research Project

Project/Area Number 18H02100
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
Research InstitutionWaseda University

Principal Investigator

NAKAO YOICHI  早稲田大学, 理工学術院, 教授 (60282696)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords幹細胞分化調節 / 天然化合物 / 天然小分子 / 作用メカニズム / 幹細胞 / 分化 / 3次元培養 / 小分子 / 分化調節
Outline of Final Research Achievements

In this research project, 3D culture system monitoring multiple cell differentiation pathways has been established. Screening for bioactive food ingredients using this system has been conducted. As the result, 48 out of 96 food samples showed some kinds of activities. The most active food sample was selected for further study to isolate active substances. The isolation is at the final step currently. Structure elucidation of the bioactive subtances will be conducted in the nearest future.

Academic Significance and Societal Importance of the Research Achievements

今回、一般的に摂取されている食品中に非常に強い血管および心筋分化誘導活性を見出している(特許申請準備中)。この発見は、普段の食事のとり方によって血管系の若さを保持するためのヒントとなりうるため、活性本体を明らかにすることで社会的に大きなインパクトを与えうる研究成果となりうる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (30 results)

All 2021 2020 2019 2018

All Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (24 results) (of which Int'l Joint Research: 8 results,  Invited: 1 results)

  • [Journal Article] Small-Scale Preparation of Fluorescently Labeled Chemical Probes from Marine Cyclic Peptides, Kapakahines A and F2021

    • Author(s)
      Kamihira Rie、Nakao Yoichi
    • Journal Title

      Marine Drugs

      Volume: 19 Issue: 2 Pages: 76-76

    • DOI

      10.3390/md19020076

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone modification dynamics as revealed by multicolor immunofluorescence-based single-cell analysis2020

    • Author(s)
      Hayashi-Takanaka Yoko、Kina Yuto、Nakamura Fumiaki、Becking Leontine E.、Nakao Yoichi、Nagase Takahiro、Nozaki Naohito、Kimura Hiroshi
    • Journal Title

      Journal of Cell Science

      Volume: 133 Issue: 14

    • DOI

      10.1242/jcs.243444

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of mycalolides isolated from a marine sponge Mycale aff. nullarosette on actin in living cells2019

    • Author(s)
      Hayashi-Takanaka Yoko、Kina Yuto、Nakamura Fumiaki、Yamazaki Shota、Harata Masahiko、Soest Rob W. M. van、Kimura Hiroshi、Nakao Yoichi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 7540-7540

    • DOI

      10.1038/s41598-019-44036-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficient route to RIKEN click probes for glycoconjugation2019

    • Author(s)
      Nakamura Kayo、Tsubokura Kazuki、Kurbangalieva Almira、Nakao Yoichi、Murase Takefumi、Shimoda Taiji、Tanaka Katsunori
    • Journal Title

      Journal of Carbohydrate Chemistry

      Volume: 38 Issue: 2 Pages: 127-138

    • DOI

      10.1080/07328303.2019.1578886

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sameuramide A, a new cyclic depsipeptide isolated from an ascidian of the family Didemnidae.2018

    • Author(s)
      Machida K, Arai D, Katsumata R, Otsuka S, Yamashita JK, Ye T, Tang S, Fusetani N, Nakao Y
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 26 Issue: 13 Pages: 3852-3857

    • DOI

      10.1016/j.bmc.2018.06.042

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium2018

    • Author(s)
      Nakamura F, Maejima H, Kawamura M, Arai D, Okino T, Zhao M, Ye T, Lee J, Chang Y-T, Fusetan N, Nakao Y
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: - Issue: 12 Pages: 2206-2209

    • DOI

      10.1016/j.bmcl.2018.04.067

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 細胞分化調節活性化合物の探索のための新規評価系の開発2020

    • Author(s)
      山崎瑞穂,中尾洋一
    • Organizer
      第10回CSJ化学フェスタ2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] Search for bioactive substances from Shiitake mushrooms (Lentinula edodes)2019

    • Author(s)
      Karino, Y.; Nakao Y.
    • Organizer
      AFPS-ICAPPS
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Marine Natural Products that Control a Specific Set of Histone Modifications2019

    • Author(s)
      Ikeda, K.; Arai, D.; Machida, K.; Hayashi-Takanaka, Y.; Kimura, H.; Fusetani, N.; Nakao Y.
    • Organizer
      XVI MaNaPro_XI ECMNP
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of Chemical Probes from Marine Natural Products2019

    • Author(s)
      Kamihira, R.; Nakao Y.
    • Organizer
      XVI MaNaPro_XI ECMNP
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Search for Marine Natural Products from the Mixtures of Marine Invertebrates in the Twilight Zone2019

    • Author(s)
      Nakamura, F.; Nakao Y.
    • Organizer
      XVI MaNaPro_XI ECMNP
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ココア主要成分テオブロミンの新たな生理作用2019

    • Author(s)
      中尾洋一
    • Organizer
      第24回 チョコレート・ココア国際栄養シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 鹿児島県産海綿からの神経分化調節化合物の探索2019

    • Author(s)
      齋藤紗季、中尾洋一
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] シイタケ由来の生物活性化合物の探索2019

    • Author(s)
      狩野有花、中尾洋一
    • Organizer
      日本化学会大99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ドレッジ採集した深海性の生物小断片混合物に着目した海洋天然化合物の探索2019

    • Author(s)
      中村文彬、中尾洋一
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Inhibition of Tumor Metastasis and Proliferation by in vivo Metal-Catalyzed Reaction2019

    • Author(s)
      Kazuki Tsubokura, Kenward Vong, Peni Ahmadi, Yoichi Nakao, Katsunori Tanaka
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Sameuramide A, a new cyclic depsipeptide isolated from an ascidian of the family Didemnidae2018

    • Author(s)
      Machida, K.; Arai, D.; Katsuata, R.; Otsuka, S.; Yamashita, J. K.; Ye, T.; Tang, S.; Fusetani, N.; Nakao, Y.
    • Organizer
      30th International Symposium on the Chemistry of Natural Products (ISCNP30 & ICOB10)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of chemical probes from marine cyclic peptides2018

    • Author(s)
      Kamihira, R.; Arai, D.; Nakao, Y.
    • Organizer
      30th International Symposium on the Chemistry of Natural Products (ISCNP30 & ICOB10)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Kakeromamide A, a new cyclic pentapeptide from the marine cyanobacterium Moorea bouilonii2018

    • Author(s)
      Nakamura, F.; Mejima, H.; Kawamura, M.; Arai, D.; Zhao, M.; Ye, T.; Fusetani, N.; Nakao, Y.
    • Organizer
      30th International Symposium on the Chemistry of Natural Products (ISCNP30 & ICOB10)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体内合成化学治療 生理活性天然物のルネッサンス2018

    • Author(s)
      坪倉一輝、Kenward Vong、Ambara Pradipta、中尾洋一、田中克典
    • Organizer
      第60回天然有機化合物討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒト慢性骨髄性白血病由来細胞株MB-1に対する海洋天然化合物の活性評価2018

    • Author(s)
      平沢元希、池田昂太郎、新井大祐、中尾洋一
    • Organizer
      第41回日本分子生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mycale属海綿に含まれるmycalolide類の単離と構造決定2018

    • Author(s)
      藤野修太郎、新井大祐、木村宏、中尾洋一
    • Organizer
      第8回CSJ化学フェスタ2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒストン修飾調節活性を示す海洋天然化合物の探索2018

    • Author(s)
      池田昴太郎、新井大祐、木村宏、中尾洋一
    • Organizer
      第8回CSJ化学フェスタ2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 遠志に含まれる時計遺伝子Per2の発現周期調節成分の探索2018

    • Author(s)
      中村文彬、原口敦嗣、阿部慎太郎、柴田重信、中尾洋一
    • Organizer
      第13回化学生態学研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 抗トリパノソーマ活性を有する海洋天然化合物2018

    • Author(s)
      伊藤駿、万場昌子、菅沼啓輔、中尾洋一
    • Organizer
      第13回化学生態学研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 抗トリパノソーマ活性を有する海洋天然化合物の探索2018

    • Author(s)
      伊藤駿、万場昌子、菅沼啓輔、中尾洋一
    • Organizer
      第13回日本ケミカルバイオロジー学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒストン修飾調節活性を有する海洋天然化合物の探索2018

    • Author(s)
      中村文彬、田中万結、新井大祐、木村宏、中尾洋一
    • Organizer
      第13回日本ケミカルバイオロジー学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 宮城県産ホヤDidemnidae sp.から得られた新規環状デプシペプチドに関する研究2018

    • Author(s)
      町田光史、勝俣良祐、新井大祐、中尾洋一
    • Organizer
      第13回日本ケミカルバイオロジー学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] シークワーサー果皮に含まれるヒストン修飾調節活性成分の探索2018

    • Author(s)
      杉崎未来、新井大祐、菅敏幸、木村宏、中尾洋一
    • Organizer
      第12回日本エピジェネティクス研究会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] コーヒー由来のヒストン修飾調節活性および神経幹細胞分化調節活性を有する化合物の探索2018

    • Author(s)
      長島侑希、新井大祐、木村宏、中尾洋一
    • Organizer
      第12回日本エピジェネティクス研究会年会
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-12-28  

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