| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Outline of Final Research Achievements |
We herein developed a "reactive-chemical tool" for subtype selective activation or regulation of plant hormone co-receptors. Plan hormones often exhibit complex activities by inducing various combinations of protein-protein interactions (PPI). In this study, we aimed to induce the desired activity of plant hormones by selectively inducing a part of PPIs by covalent bond formation with plant hormone receptors. During the research period, we were able to devise a basic chemical strategy, and verify the proof-of-princible with a model system.
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