Molecular mechanism on PRR (Pseudo Response Regulators)-mediated epigenetic regulation underlying robust circadian clock oscillation in higher plants
Project/Area Number |
18H02137
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 38030:Applied biochemistry-related
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Research Institution | Nagoya University |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
|
Keywords | 植物の概日時計 / 転写調節 / エピゲノム / 植物概日時計 / 転写制御 / タンパク質間相互作用 / シロイヌナズナ / 概日リズム / クロマチン / 遺伝子発現調節 / 概日時計 / 擬似レスポンスレギュレーター / 植物時計 / 光情報伝達 / レスポンスレギュレーター / エピゲノム修飾 / ヒストン修飾 / クロマチン構造制御 |
Outline of Final Research Achievements |
The gate effect of the biological clock supports oscillations of clock genes that are robust to environmental fluctuations by restricting the input of environmental signals to specific time periods. DNA methylation and histone acetylation in the regulatory regions of gene expression are known to cause conformational changes in chromatin that define the potential for transcriptional activity. In this study, we focus on the PRR family and its target gene CCA1/LHY, which form a negative feedback loop circuit in the central oscillator of Arabidopsis thaliana, to clarify how the PRR family plays a role in the regulation of chromatin structure in the central oscillator.
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Academic Significance and Societal Importance of the Research Achievements |
概日リズムを生成する植物時計の中心振動体タンパク質は外環境に同調しながら24時間周期で発現レベルが変動することが知られている。この振動の振幅は100倍以上の振れ幅をもち自由継続する性質も兼ね備えている。本研究では中心振動体のrobustな振動特性を支える背景にはエピゲノム制御を介した日周レベルのクロマチンダイナミズムが存在することを明らかにした。
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Report
(5 results)
Research Products
(25 results)
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[Journal Article] The cereal pathogen Fusarium pseudograminearum produces a new class of active cytokinins during infection.2018
Author(s)
Sorensen JL, Benfield AH, Wollenberg RD, Westphal K, Wimmer R, Nielsen MR, Nielsen KF, Carere J, Covarelli L, Beccari G, Powell J, Yamashino T, Kogler H, Sondergaard TE, Gardiner DM.
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Journal Title
Mol Plant Pathol.
Volume: 19
Issue: 5
Pages: 1140-1154
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Light-regulated PAS-containing histidine kinases delay gametophore formation in the moss Physcomitrella patens2018
Author(s)
Ryo, M., Yamashino, T., Nomoto, Y., Goto, Y., Ichinose, M., Sato, K., Sugita, M. and Aoki, S.
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Journal Title
J. Exp. Bot.
Volume: 69
Issue: 20
Pages: 4839-4851
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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