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Regulation of chronic inflammation in aging and adipose tissues via the intestinal immune system by food

Research Project

Project/Area Number 18H02152
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 38050:Food sciences-related
Research InstitutionThe University of Tokyo

Principal Investigator

HACHIMURA Satoshi  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (40238019)

Co-Investigator(Kenkyū-buntansha) 足立 はるよ (中嶋はるよ)  東京大学, 大学院農学生命科学研究科(農学部), 特任助教 (20595962)
宮川 拓也  東京大学, 大学院農学生命科学研究科(農学部), 特任准教授 (50596559)
細野 朗  日本大学, 生物資源科学部, 教授 (70328706)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords腸管免疫系 / 慢性炎症 / 加齢性炎症 / 脂肪組織 / 樹状細胞 / 制御性T細胞 / 機能性食品 / 食品 / マクロファージ / 腸管バリア / 加齢
Outline of Final Research Achievements

We aimed to elucidate the relationship between age-related inflammation, chronic inflammation in adipose tissues and the intestinal immune system, and we tried to find food component(s) that are capable of inhibiting chronic inflammation. We found that decrease in retinoic acid production from intestinal dendritic cells was involved in the age-related decrease in antigen-specific regulatory T cell induction. This may be related to age-related diseases due to age-related chronic inflammation. We next found that oral administration of β-elemene downregulated expression of inflammatory cytokines and increased Foxp3+CD4+ T cells in adipose tissue of obese mice. β-elemene increased Foxp3+CD4+ T cells in the intestinal immune system, enhancing expression of regulatory T cell-inducing factors of dendritic cells. Our results suggested that β-elemene could alleviate fat tissue-related inflammation through modulation of the intestinal immune system by inducing regulatory T cells.

Academic Significance and Societal Importance of the Research Achievements

本研究において、加齢性炎症における腸管免疫系の関与を示すことができた。また、これまで、食品による脂肪組織の慢性炎症の抑制が腸管免疫系を介していることを明確に示した例がなく、本研究において、樹状細胞の機能変化が要因となることを初めて示した。本研究は、加齢による炎症による疾患や肥満による生活習慣病を、免疫機能食品により予防、改善するための基盤となることが期待される。

Report

(2 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )

Research Products

(11 results)

All 2021 2020 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] 小腸と大腸の腸管関連リンパ組織B細胞の抗体発現と血清中抗体量の相関における腸内細菌の関与.2021

    • Author(s)
      津田真人,細野朗
    • Journal Title

      無菌生物 (Journal of Germfree Life and Gnotobiology)

      Volume: 50 Pages: 88-90

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highlighting the potential utility of MBP crystallization chaperone for Arabidopsis BIL1/BZR1 transcription factor-DNA complex2021

    • Author(s)
      Nosaki Shohei、Terada Tohru、Nakamura Akira、Hirabayashi Kei、Xu Yuqun、Bui Thi Bao Chau、Nakano Takeshi、Tanokura Masaru、Miyakawa Takuya
    • Journal Title

      Sci. Rep.

      Volume: 11 Pages: 3879-3879

    • DOI

      10.1038/s41598-021-83532-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells2020

    • Author(s)
      Takano Tomohiro、Kotaki Ryutaro、Park Jihyun、Yoshida Tadashi、Wakatsuki Yoshio、Tanokura Masaru、Miyakawa Takuya、Takahashi Kyoko、Nakajima-Adachi Haruyo、Hachimura Satoshi
    • Journal Title

      Front. Immunol.

      Volume: 11 Pages: 1555-1555

    • DOI

      10.3389/fimmu.2020.01555

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intestinal regulatory T cell induction by β-elemene alleviates the formation of fat tissue-related inflammation.2020

    • Author(s)
      Zhou Y, Takano T, Wang Y, Li X, Wang R, Wakatsuki Y, Nakajima-Adachi H, Tanokura M, Miyakawa T, Hachimura S.
    • Journal Title

      iScience

      Volume: 24 Pages: 101883-101883

    • DOI

      10.1016/j.isci.2020.101883

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Intestinal Regulatory T Cell Induction by β-Elemene Alleviates the Formation of Fat Tissue-Related Inflammation.2021

    • Author(s)
      ZHOU Yingyu,TAKANO Tomohiro,WANG Yimei, LI Xuyang,WANG Rong,WAKATSUKI Yoshio,ADACHI(NAKAJIMA) Haruyo,TANOKURA Masaru, MIYAKAWA Takuya,HACHIMURA Satoshi
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Lactobacillus plantarum OLL2712株の経口投与が高脂肪食を摂取したマウス体内における抗炎症作用を発揮する経路の検討.2021

    • Author(s)
      王 イバイ,高野 智弘,周 英ギョク,王 蓉,田之倉 優,宮川 拓也,足立(中嶋) はるよ,八村 敏志
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] クルクミンと腸内細菌および短鎖脂肪酸の共刺激がパイエル板細胞応答を修飾する.2021

    • Author(s)
      柴崎 涼太,古川 凱斗,津田 真人,高野 智弘,王 イバイ, 戸塚 護,八村 敏志,細野 朗
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 無菌動物を利用した食品機能性研究と同実験施設の管理.2021

    • Author(s)
      細野朗
    • Organizer
      第54回日本無菌生物ノートバイオロジー学会総会シンポジウムⅡ「無菌生物の技術と応用」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Intestinal Regulatory T Cell Induction by β-Elemene Alleviates the Formation of Fat Tissue-Related Inflammation.2020

    • Author(s)
      Yingyu Zhou, Tomohiro Takano, Yimei Wang, Xuyang Li, Rong Wang, Haruyo Nakajima-Adachi, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura
    • Organizer
      9th International Conference on Nutrition and Food Sciences (ICNFS 2020)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食品成分,腸内細菌および腸内細菌代謝産物の共刺激がIgA産生に与える影響.2020

    • Author(s)
      柴﨑涼太,古川凱斗,津田真人,高野智弘,戸塚護,八村敏志,細野朗
    • Organizer
      第24回腸内細菌学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Remarks] 東京大学大学院農学生命科学研究科・研究成果 「加齢による制御性T細胞誘導能の低下は…」

    • URL

      https://www.a.u-tokyo.ac.jp/topics/topics_20201028-2.html

    • Related Report
      2020 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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