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Studies on the mechanisms underlying formation and maintenance of motivation and its regulation with food

Research Project

Project/Area Number 18H02156
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 38050:Food sciences-related
Research InstitutionKyoto University

Principal Investigator

Inoue Kazuo  京都大学, 農学研究科, 教授 (80213148)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywords疲労 / 動機 / 持久運動能力 / 自発行動 / 自発運動 / 中鎖脂肪酸 / カフェイン
Outline of Final Research Achievements

With the improvement for evaluation of animal behavior, the methods for measurement of motivation to act and fatigue in which the will for action declined were developed. Using optogenetically modified mice whose neuronal activities can tissue-specifically be modulated with light, the pivotal roles of brain reward system for the will for action was demonstrated. The diet that increased the endurance capability and spontaneous motor activities in mice was classified into A) enhancer of exercise ability and B) contributor of formation and maintenance of the motivation to exercise judging from their mechanism of action.

Academic Significance and Societal Importance of the Research Achievements

疲労に抗して行動を行うためには、脳報酬系の活動の亢進が有効であることを示した。そのような機能を持つ薬物はしばしば中毒性を持つため、習慣性が生じる恐れがない食品でその機能が代替できるものが求められる。本研究では、実験動物の行動する意欲を指標に検討を行い、カフェインや中鎖脂肪酸に加え、幾つかの香気成分で動機を高める作用が得られることを示した。エネルギー代謝の効率化に加え、行動する意欲を高めることが抗疲労・疲労回復機能につながることが示唆された。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (2 results)

All 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Low-fat diet, and medium-fat diets containing coconut oil and soybean oil exert different metabolic effects in untrained and treadmill-trained mice2018

    • Author(s)
      Manio Mark Christian、Matsumura Shigenobu、Inoue Kazuo
    • Journal Title

      Journal of the International Society of Sports Nutrition

      Volume: 15 Issue: 1 Pages: 1-16

    • DOI

      10.1186/s12970-018-0234-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 中枢性疲労を軽減する食品成分の探索2018

    • Author(s)
      志村 広樹、井上 和生
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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