|Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2019: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|Outline of Final Research Achievements
The longest-lived rodent, the naked mole-rat (NMR), has strong resistance to aging and cancer. In general, chronic inflammation is closely related to aging-related diseases and carcinogenesis. In this study, we focused on the attenuation of inflammatory responses in NMR tissues. Chronic inflammation associated with obesity is one of the causes of metabolic diseases. We showed that the NMRs do not become obese by consuming a high-fat or high-sugar diet and does not show fatty liver or glucose intolerance. We found that reduced glucose metabolism in NMRs may be involved in this resistance. We also identified a novel gene mutation that may be involved in the NMR-specific attenuation of inflammatory responses.