The role of intracellular organelles to regulate spatial organizations of the cell
Project/Area Number |
18H02414
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 43040:Biophysics-related
|
Research Institution | National Institute of Genetics |
Principal Investigator |
KIMURA AKATSUKI 国立遺伝学研究所, 遺伝メカニズム研究系, 教授 (10365447)
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2021)
|
Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
Keywords | 線虫 / 細胞核 / 細胞質流動 / オルガネラ / 力学 / 数理モデル |
Outline of Final Research Achievements |
Inside the cell, various dynamic movements of its interior structures are observed, such as the cell nucleus’s movement from the edge to the center of the cell, or the cytoplasmic streaming throughout the cell. We have been proposing that intracellular organelles such as the endoplasmic reticulum (ER) play an important role in these dynamic movements as mechanical elements that generate and integrate forces. In this research project, we were able to demonstrate that intracellular movements with organelles as mechanical elements are important for cellular dynamics. The dynamics included the mode of cell division and the formation of the body axis of an individual. The studies were conducted by combining microscopic observation of a nematode, Caenorhabditis elegans, and mathematical modeling.
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Academic Significance and Societal Importance of the Research Achievements |
細胞内小器官は従来は細胞内のエネルギー産生や物質のリサイクルなど、その機能的役割に注目されてきたが、細胞内の相当な体積を占める構造体であり、細胞骨格と連結されているなど細胞内の力学的要素としても重要な役割を果たすことが疑われる。これまで注目されていなかったこの役割に本研究では迫り、細胞がどのように分裂するか、身体の前後軸がどのように決定されるか、といった重要な制御にオルガネラが細胞内の重要な力学的要素として関わっていることを明らかにした。
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Report
(4 results)
Research Products
(32 results)
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[Book] 細胞建築学入門2019
Author(s)
木村暁
Total Pages
127
Publisher
工学社
ISBN
9784777520954
Related Report
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[Book] 定量生物学2018
Author(s)
小林 徹也
Total Pages
250
Publisher
化学同人
ISBN
9784759817300
Related Report
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