| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
Tricellular tight junctions (tTJs) are intercellular junctions that seal the intercellular space at tricellular contacts, where the vertices of three epithelial cells meet, and contribute to the epithelial barrier function. Tricellulin and angulin family of membrane proteins are known constituents of tTJs, but the roles of these proteins in tTJ formation remains elusive. In this study, we have demonstrated that angulin-1, not tricellulin, is responsible for the plasma membrane contact at tricellular contacts.
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