| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
The germ cells are born in extraembryonic region, and migrate toward the gonad. Why the germ cells are formed outside the embryo (gonad) is one of major problems in developmental biology, but it remains unknown. We approached this problem by elucidating the mechanism of maintenance and migration of germ cells outside the gonad. The material is avian embryos in which primordial germ cells (PGCs) use blood vessels as the pathway to the gonad. We revealed the cellular mechanism by which PGCs relocate into blood vessels (PGC envelopment by endothelial cells during angiogenesis), and the mechanism by which PGC extravasation (occlusion of circulating PGCs in micro-capillaries due to PGC high stiffness, and transmigration using membrane blebs). Furthermore, we found that excessive input of FGF signals into PGCs transform them into large tumor-like clusters in the dorsal mesentery.
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