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Integration of nutrient and microbial cues in the regulation of plant immunity

Research Project

Project/Area Number 18H02467
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 44030:Plant molecular biology and physiology-related
Research InstitutionNara Institute of Science and Technology

Principal Investigator

Saijo Yusuke  奈良先端科学技術大学院大学, 先端科学技術研究科, 教授 (50587764)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords植物微生物相互作用 / 植物免疫 / 共生 / 環境応答 / 土壌栄養 / 貧栄養 / マイクロバイオーム / リン / PSR / 微生物 / シグナル伝達 / 受容体 / 栄養 / 環境適応
Outline of Final Research Achievements

This project aims at a better understanding of the mechanisms by which plants integrate microbial and nutritional cues to finetune their immune responses to pathogenic and mutualistic microbes. We show that damage-inducible Pep peptides provides a pathogen-specific defense pathway, which is sensitized under phosphate deficiency in which plants typically rely on mutualistic microbes for nutrition. Our investigation into the molecular links between immune and phosphate starvation response (PSR) pathways reveals a key role played by PMR4 callose synthase in root callose deposition and phosphate acquisition during PSR. Conversely, our genetic studies on PSR pathways via PHR1/PHL1 transcription factors and LPR1/LPR2 ferroxydases further show their critical role in the control of root-associated microbiomes even under nutrient sufficiency. These findings shed new light on a previously unsuspected, intimate linkage between plant immunity and nutrition deficiency responses.

Academic Significance and Societal Importance of the Research Achievements

植物と微生物の関係性は環境に応じて大きく変わるものの、その実態や制御機構の解明は遅れている。共生菌に依存する低リン条件で病原菌の防除に働くPepペプチドシグナル系の解明は、栄養情報にもとづき植物が免疫・共生制御を行う仕組みの一端を明らかにしており、国内外で求められている植物微生物環境の三者相互作用研究に先鞭をつけるものである。また、野外環境で実効性の高い病害抵抗性作物や共生菌制御技術の開発に向けても有意義な知見を提供している。本成果は、環境変動に耐える頑強な作物の作出や効率的な共生菌・土壌栄養利用を可能にし、持続可能な食料生産システムの構築に貢献するものである。

Report

(3 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(20 results)

All 2020 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (10 results) (of which Int'l Joint Research: 6 results,  Invited: 10 results)

  • [Int'l Joint Research] University of Montpellier/INRA/CNRS(フランス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] MPIPZ(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] CEA/CNRS(フランス)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Protein Phosphorylation Dynamics Under Carbon/Nitrogen-Nutrient Stress and Identification of a Cell Death-Related Receptor-Like Kinase in Arabidopsis2020

    • Author(s)
      Li Xingwen、Sanagi Miho、Lu Yu、Nomura Yuko、Stolze Sara Christina、Yasuda Shigetaka、Saijo Yusuke、Schulze Waltraud X.、Feil Regina、Stitt Mark、Lunn John E.、Nakagami Hirofumi、Sato Takeo、Yamaguchi Junji
    • Journal Title

      Frontiers in Plant Science

      Volume: 11 Pages: 1-15

    • DOI

      10.3389/fpls.2020.00377

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SUPPRESSOR OF GAMMA RESPONSE 1 acts as a regulator coordinating crosstalk between DNA damage response and immune response in Arabidopsis thaliana2020

    • Author(s)
      Yoshiyama Kaoru Okamoto、Aoshima Naoki、Takahashi Naoki、Sakamoto Tomoaki、Hiruma Kei、Saijo Yusuke、Hidema Jun、Umeda Masaaki、Kimura Seisuke
    • Journal Title

      Plant Mol Biol

      Volume: 103 Pages: 321-340

    • DOI

      10.1007/s11103-020-00994-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plant immunity in signal integration between biotic and abiotic stress responses.2020

    • Author(s)
      Saijo Y, Loo EP.
    • Journal Title

      New Phytologist

      Volume: 225 Pages: 87-104

    • DOI

      10.1111/nph.15989

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pattern recognition receptors confer plant salt tolerance via WRKY18/WRKY40 transcription factors2020

    • Author(s)
      Eliza P. Loo, Yuri Tajima, Kohji Yamada, Taishi Hirase, Hirotaka Ariga, Tadashi Fujiwara, Keisuke Tanaka, Teruaki Taji, Imre E. Somssich, Jane E. Parker, Yusuke Saijo
    • Journal Title

      bioRxiv

      Volume: 2020

    • DOI

      10.1101/2020.05.07.082172

    • Related Report
      2019 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Integration of danger peptide signals with HAMP signaling amplifies the anti-herbivore defense responses in rice2018

    • Author(s)
      Shinya Tomonori、Yasuda Shigetaka、Hyodo Kiwamu、Tani Rena、Hojo Yuko、Fujiwara Yuka、Hiruma Kei、Ishizaki Takuma、Fujita Yasunari、Saijo Yusuke、Galis Ivan
    • Journal Title

      Plant J

      Volume: 印刷中 Pages: 626-637

    • DOI

      10.1111/tpj.13883

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis.2018

    • Author(s)
      Ogita N, Okushima Y, Tokizawa M, Yamamoto YY, Tanaka M, Seki M, Makita Y, Matsui M, Okamoto-Yoshiyama K, Sakamoto T, Kurata T, Hiruma K, Saijo Y, Takahashi N, Umeda M.
    • Journal Title

      The Plant Journal

      Volume: - Pages: 439-453

    • DOI

      10.1111/tpj.13866

    • NAID

      120006411144

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pattern recognition receptors and signaling in plant-microbe interactions.2018

    • Author(s)
      Saijo Y, Loo EP, and Yasuda S.
    • Journal Title

      The Plant Journal

      Volume: 93 Pages: 592-613

    • DOI

      10.1111/tpj.13808

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Pattern recognition receptors mediate direct apoplastic resistance against bacterial water acquisition in plants2019

    • Author(s)
      Yusuke Saijo
    • Organizer
      The 30th International Conference on Arabidopsis Research,
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pattern recognition receptors confer direct apoplastic resistance against bacterial water acquisition in plants.2019

    • Author(s)
      Yusuke Saijo
    • Organizer
      International Symposium on Plant Receptor Kinases and Cell Signaling 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phosphate status-dependent control of associations with beneficial and pathogenic fungi in Arabidopsis thaliana2019

    • Author(s)
      Tae-Hong Lee, Takuma Inoue, Midori Tanaka, Taishi Hirase, Shigetaka Yasuda, Kei Hiruma and Yusuke Saijo
    • Organizer
      2019 IS-MPMI XVIII Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pattern-triggered immunity under water stress conditions2019

    • Author(s)
      Yusuke Saijo
    • Organizer
      Japan-Taiwan Plant Biology 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pattern recognition receptors in fluctuating environments2018

    • Author(s)
      Lee T, Loo EP, Tanaka M, Tajima Y, Hirase T, Yamada K, Yasuda S, Hiruma K and Saijo Y.
    • Organizer
      International Plant Molecular Biology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 微生物の認識と制御を介した植物の環境適応2018

    • Author(s)
      西條雄介
    • Organizer
      第53回感染生理談話会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] リン栄養環境情報に基づく植物免疫の制御2018

    • Author(s)
      西條雄介
    • Organizer
      第4回植物栄養研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 微生物情報と環境情報の統合に基づく植物免疫の制御と環境適応2018

    • Author(s)
      西條雄介
    • Organizer
      第28回植物微生物研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 植物のパターン認識受容体を介した微生物の認識・制御と環境適応2018

    • Author(s)
      西條雄介
    • Organizer
      日本育種学会平成30年度秋季大会ワークショップ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Integration of microbial and environmental cues in plant immunity2018

    • Author(s)
      Yusuke Saijo
    • Organizer
      ICPS (EIG-CENCERT) symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2018-04-23   Modified: 2023-01-30  

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