Deciphering the Evolutionary Reduction of Skull Bones from Suture Closure
Project/Area Number |
18H02492
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 45030:Biodiversity and systematics-related
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Research Institution | University of Tsukuba (2020, 2022) Tokyo Medical and Dental University (2019) Musashino Art University (2018) |
Principal Investigator |
Koyabu Daisuke 筑波大学, プレシジョン・メディスン開発研究センター, 准教授 (60712510)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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Keywords | 進化 / 進化発生学 / 比較解剖学 / 頭蓋 / 形態学 |
Outline of Final Research Achievements |
The aim of this study was to determine how the crania of amniotes, which consist of birds, reptiles and mammals, are homologous between the various phylogenetic groups. Our previous studies have shown that the conventional theory of vertebrate cranial homology requires a complete reconsideration. In the course of this reexamination, we focused on the phenomenon of suture closure between bones. We were able to overturn the conventional understanding of the homology of mammalian premaxillary bone from both the macroscopic approach of comparative anatomy and palaeontology and experimental embryology. We proposed to dismiss the anatomical names given to each bone of the skull since the 18th century and to construct a new framework of cranial bone identity based on the suture closure between the bones. The results of this study have opened the avenue to a new framework of cranial bone homology.
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Academic Significance and Societal Importance of the Research Achievements |
ヒトの頭蓋骨は30数個の骨パーツが認識されており,解剖学的定義づけにより各骨パーツに解剖学名称が与えられてきた.これらの名称はヒトだけでなく,他の哺乳類,鳥類,爬虫類といったあらゆる羊膜類の頭骨パーツの解剖学名称にも適用,流用されてきた.しかし,同一名称がついているからといって,相同ではないということが一部の骨について本課題により明らかとなり,同一の骨として扱うことはできないことが示された.基礎生物学にとどまらず,医学,獣医学といった応用領域にとっても極めて重要な知見であり,特に頭部おける先天形態異常の原因解明と先制治療に向けた学術的貢献が大きいといえる.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Mammalian face as an evolutionary novelty2021
Author(s)
Higashiyama H, Koyabu D, Hirasawa T, Werneburg I, Kuratani S, Kurihara H
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Journal Title
Proceedings of the National Academy of Sciences of the United States of America
Volume: 118
Issue: 44
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Embryonic staging of bats with special reference to Vespertilo sinensis and its cochlear development.2021
Author(s)
Nojiri, T., Fukui, D., Werneburg, I., Saitoh, T., Endo, H., and Koyabu, D.
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Journal Title
Developmental Dynamics
Volume: 4
Issue: 8
Pages: 1-20
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Non-invasive age estimation by cranial suture closure in Japanese sika deer (Cervus nippon).2019
Author(s)
Oh, J.W., Minami, M.,Ikeda, S.,Takatsuki, S., Oonishi, N, Higuchi, N., Okada, A., Kimura, J., Koyabu, D
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Journal Title
Mammal Study
Volume: 印刷中
Issue: 3
Pages: 147-147
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Prenatal cranial bone development of Thomas’s horseshoe bat (Rhinolophus thomasi): with special reference to petrosal morphology.2018
Author(s)
Nojiri, T., Werneburg, I., Son, N.T., Tu, V.T., Sasaki, T., Maekawa, Y., Koyabu, D.
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Journal Title
Journal of Morphology
Volume: in press
Issue: 6
Pages: 809-827
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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