Molecular and neural mechanism of memory regulation during sleep
Project/Area Number |
18H02523
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 46010:Neuroscience-general-related
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Research Institution | Nagoya University |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
Keywords | 睡眠覚醒 / 記憶 / 海馬 / 光遺伝学 / 化学遺伝学 / マウス / 遺伝子改変動物 / カルシウムイメージング / メラニン凝集ホルモン産生神経 / 視床下部 / メラニン凝集ホルモン / 遺伝子改変マウス / 睡眠 / オレキシン / 神経ペプチド / アデノ随伴ウイルスベクター / メラニン凝集ホルモン(MCH)神経 / 脳波筋電図 / レム睡眠 / nVista |
Outline of Final Research Achievements |
MCH neural activity was manipulated and memory was evaluated by applying optogenetics and chemo genetics specifically to MCH neurons. We found that memory was deteriorated when MCH nerve activity was activated, and that memory was improved when MCH nerve activity was suppressed. The next, memory was evaluated by suppressing the MCH nerve activity using the optogenetics with brain state-dependent-manner. As the result, it was clarified that the memory was improved by suppressing REM-sleep active MCH neurons. This suggests that MCH neurons, which are active during REM sleep, are erasing memory. We proposed that REM sleep plays a role in memory erasure, and identified the neural circuits involved in memory erasure and clarified their working principles.
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Academic Significance and Societal Importance of the Research Achievements |
睡眠覚醒調節のメカニズムや、睡眠中の記憶の制御メカニズムについてはほとんど分かっていない。本研究結果によって、生理機能がほとんど分かっていないレム睡眠に記憶消去の役割があること、視床下部のメラニン凝集ホルモン産生神経が、海馬に投射して、レム睡眠時に記憶消去を行っていることを明らかにした。睡眠や記憶のメカニズムがほとんど分かっていないため、心的外傷後ストレス障害(PTSD)などの記憶に問題がある疾患の治療法は極めて限られている。本研究結果によって、これらの疾患に対して新しい治療法開発の可能性が出てきた。
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Report
(4 results)
Research Products
(88 results)
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[Journal Article] Direct evidence that the brain reward system is involved in the control of scratching behaviors induced by acute and chronic itch2021
Author(s)
Setsu T, Hamada Y, Oikawa D, Mori T, Ishiuji Y, Sato D, Narita M, Miyazaki S, Furuta E, Suda Y, Sakai H, Ochiya T, Tezuka H, Iseki M, Inada E, Yamanaka A, Kuzumaki N, Narita M.
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Journal Title
Biochem Biophys Res Commun
Volume: 534
Pages: 624-631
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway.2021
Author(s)
Lin, Y-H., Yamahashi, Y., Kuroda, K., Faruk M. O., Zhang, X., Yamada, K., Yamanaka, A., Nagai, T., Kaibuchi, K.
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Journal Title
Neurochem Int
Volume: 143
Pages: 104935-104935
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice2020
Author(s)
Flanigan ME, Aleyasin H, Li L, Burnett CJ, Chan KL, LeClair KB, Lucas EK, Matikainen-Ankney B, Cuttoli RD, Takahashi A, Menard C, Pfau ML, Golden SA, Bouchard S, Calipari ES, Nestler EJ, DiLeone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ
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Journal Title
Nat Neurosci
Volume: -
Pages: 638-650
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.2020
Author(s)
Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K, Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K.
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Journal Title
Addict Biol
Volume: 印刷中
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Acute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice.2020
Author(s)
Wada S, Yanagida J, Sasase H, Zhang T, Li X, Kamii H, Domoto M, Deyama S, Hinoi E, Yamanaka A, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K
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Journal Title
Neuropharmacology.
Volume: 166
Pages: 107968-107968
DOI
Related Report
Peer Reviewed
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[Journal Article] Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice2019
Author(s)
Chowdhury S, Hung CJ, Izawa S, Inutsuka A, Kawamura M, Kawashima T, Bito H, Imayoshi I, Abe M, Sakimura K, *Yamanaka A
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Journal Title
eLife
Volume: 8
Pages: 1-25
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories.2019
Author(s)
Izawa S, Chowdhury S, Miyazaki T, Mukai Y, Ono D, Inoue R, Ohmura Y, Mizoguchi H, Kimura K, Yoshioka M, Terao A, Kilduff TS, Yamanaka A*
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Journal Title
Science
Volume: 365
Issue: 6459
Pages: 1308-1313
DOI
NAID
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Upconversion Amplification through Dielectric Superlensing Modulation.2019
Author(s)
Liang L, Teb D, Dinh ND, Chen W, Chen Q, Wu Y, Chowdhury S, Yamanaka A, Sum TC, Chen CH, Thakor N, All A, Liu X
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Journal Title
Nat Commun
Volume: 10(1)
Issue: 1
Pages: 1391-1391
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy.2018
Author(s)
Thannickal TC, John J, Shan L, Swaab DF, Wu MF, Ramanathan L, McGregor R, Chew KT, Cornford M, Yamanaka A, Inutsuka A, Fronczek R, Lammers GJ, Worley PF, Siegel JM.
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Journal Title
Sci Transl Med
Volume: 10
Pages: 447-447
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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