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Neural mechanisms for associating emotion with social memory

Research Project

Project/Area Number 18H02544
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionThe University of Tokyo

Principal Investigator

Okuyama Teruhiro  東京大学, 定量生命科学研究所, 准教授 (80625955)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywords社会性記憶 / 海馬腹側CA1 / 光遺伝学 / 神経生理学 / 側坐核 / 扁桃体 / 海馬 / 情動 / マウス / vCA1 / BLA
Outline of Final Research Achievements

Many social animals, including humans, can recognize and remember other individuals (i.e. having "social memory") and elicit appropriate social behaviors toward each individual. Although we previously found that social memory is stored in the ventral CA1 neurons in the hippocampus (Science, 2016), how the social memory is associate with emotional valences to generate feelings of "like/dislike" toward specific persons. In this study, our results showed that ventral CA1 neurons storing social memories have a direct neural projection to the amygdala, and these neural circuits were essential to associate social memory with positive and negative valence information.

Academic Significance and Societal Importance of the Research Achievements

私たちは、友人のことを記憶し、そのそれぞれの相手に対して、好きや嫌いといった感情を抱く事ができます。私たちの研究グループでは、以前に記憶中枢である「海馬」という脳領域に、「友人のことを記憶する」ための神経細胞が存在することを見出していましたが、一方で、そのそれぞれの相手に対して、どのようにして好き・嫌いといったプラスやマイナスの感情の情報を組み合わせているのかはわかっていませんでした。本研究では、この海馬という脳領域が、感情を司る「扁桃体」という脳領域との間で、情報をやりとりする事により、好き・嫌いという感情が生まれているということを発見しました。

Report

(2 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • Research Products

    (6 results)

All 2020 2019

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results)

  • [Journal Article] Sexually dimorphic role of oxytocin in medaka mate choice2020

    • Author(s)
      Yokoi Saori、Naruse Kiyoshi、Kamei Yasuhiro、Ansai Satoshi、Kinoshita Masato、Mito Mari、Iwasaki Shintaro、Inoue Shuntaro、Okuyama Teruhiro、Nakagawa Shinichi、Young Larry J.、Takeuchi Hideaki
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 9 Pages: 4802-4808

    • DOI

      10.1073/pnas.1921446117

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The blockade of oxytocin receptors in the paraventricular thalamus reduces maternal crouching behavior over pups in lactating mice.2020

    • Author(s)
      A. Watarai, S. Tsutaki, K. Nishimori, T. Okuyama, K. Mogi, T. Kikusui
    • Journal Title

      Neuroscience Letters

      Volume: 720 Pages: 134761-134761

    • DOI

      10.1016/j.neulet.2020.134761

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] Social memory representation in the hippocampus2019

    • Author(s)
      Teruhiro Okuyama
    • Organizer
      Toyama Forum for Academic Summit on“Dynamic Brain”
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 光遺伝学を用いた、海馬における社会性記憶の解析2019

    • Author(s)
      Teruhiro Okuyama
    • Organizer
      日本動物学会 第90回 大阪大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Social memory representation in the hippocampus2019

    • Author(s)
      Teruhiro Okuyama
    • Organizer
      光操作研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Social memory engram in the hippocampus2019

    • Author(s)
      Teruhiro Okuyama
    • Organizer
      Cold Spring Harbor Asia, Francis Crick Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2018-04-23   Modified: 2022-01-27  

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