Neural circuit mechanisms underlying behavioral control through corticostriatal pathways in an area- and input-specific manner
Project/Area Number |
18H02545
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 46030:Function of nervous system-related
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Research Institution | Fukushima Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
西澤 佳代 福島県立医科大学, 医学部, 助教 (30644108)
瀬戸川 将 福島県立医科大学, 医学部, 博士研究員 (30760508)
加藤 成樹 福島県立医科大学, 医学部, 准教授 (90443879)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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Keywords | 経路選択的操作 / 細胞標的法 / 化学遺伝学 / オペラント学習 / 皮質線条体路 |
Outline of Final Research Achievements |
In this project, we aim to analyze the behavioral functions of corticotriatal neurons, focusing on the projections arising from the motor cortex and auditory cortex. SSelective neural pathway targeting and chemogenetic suppression indicated the importance of M1 corticostriatal neurons in the formation of habitual behavior. Selective elimination of PT type neurons appeared to reduce the habit formation, and the analysis of the effect of IT type ablation is in progress. In addition, 18FDG-PET and electrophysiological recording experiments showed the increased brain activity in the posterior ventrolateral striatum (pVLS) during the late phase of auditory discrimination. Retrograde axonal tracing from this region indicated dense innervation from the secondary auditory cortex and insular cortex to the pVLS. The behavioral and physiological roles of these corticostriatal neurons will be clarified in the future.
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Academic Significance and Societal Importance of the Research Achievements |
大脳皮質と基底核を結ぶネットワークは、学習の獲得、実行、行動切り替えなどさまざまな行動制御に関わることが知られているが、それぞれの皮質領野から線条体に入力する経路の役割や異なる投射特性を持つIT型・PT型ニューロンの機能の相違についてはほとんど研究が進んでいない。これらの多様な特性を持つ皮質線条体ニューロンの機能を明らかにすることは学術的な意義が深い。また、皮質線条体路の異常は、統合失調症、注意多動性障害、依存などの精神疾患の病態と深く関連することから、これらの経路の生理機能の理解は精神疾患の病態解明や治療法の開発に繋がる可能性がある。
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Impaired cortico-striatal excitatory transmission triggers epilepsy2019
Author(s)
Miyamoto Hiroyuki、Tatsukawa Tetsuya、Shimohata Atsushi、Yamagata Tetsushi、Suzuki Toshimitsu、Amano Kenji、Mazaki Emi、Raveau Matthieu、Ogiwara Ikuo、Oba-Asaka Atsuko、Hensch Takao K.、Itohara Shigeyoshi、Sakimura Kenji、Kobayashi Kenta、Kobayashi Kazuto、Yamakawa Kazuhiro
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Journal Title
Nature Communications
Volume: 10
Issue: 1
Pages: 1917-1917
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.2018
Author(s)
Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR.
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Journal Title
Cell Rep.
Volume: 24
Issue: 8
Pages: 2196-2210
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways2018
Author(s)
Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, Isomura Y, Kimura M
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Journal Title
Neuron
Volume: 99(6)
Issue: 6
Pages: 1302-1314
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Identification of indirect pathway neurons and dopaminergic innervation in the rat dorsomedial striatum2018
Author(s)
Satoshi Nonomura, Shigeki Kato, Yoshio Iguchi, Kayo Nishizawa, Yutaka Sakai, Yasuo Kawaguchi, Atsushi Nambu, Masahiko Watanabe, Kazuto Kobayashi, Yoshikazu Isomura, Minoru Kimura
Organizer
The 41st Annual Meeting of the Japan Neuroscience Society
Related Report
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