Elucidation of osmo-physiology through analysis where and how osmotic circumstance functions in the body
| Project/Area Number |
18H02569
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Naguro Isao 東京大学, 大学院薬学系研究科(薬学部), 准教授 (80401222)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | Osmo-physiology / 浸透圧 / ASK3 / LLPS / NFAT5 / 細胞代謝 / マクロファージ / 代謝変化 / osmo-physiology / 脂質分子 |
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| Outline of Final Research Achievements |
In this project, I investigated the importance of osmotic environment for organisms in a viewpoint of molecular biology and found several new molecular mechanisms that govern ASK3 signaling, gene expression via NFAT5 and cellular metabolism in osmotic stress conditions. These our results will contribute to figure out the molecular basis by which cells recognize and respond to osmotic stress, and help to link osmotic environment to immune cell regulation in certain inflammatory diseases.
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| Academic Significance and Societal Importance of the Research Achievements |
特に哺乳類細胞では、浸透圧という物理量がどのような分子メカニズムで感知され、生理応答につながるか未解明な部分が残されているが、本研究によりリン酸化シグナル伝達、遺伝子発現、細胞代謝という複数の階層における浸透圧応答メカニズムが明らかになった。近年、高食塩食は高血圧のみならず、自己免疫疾患など炎症性疾患の増悪要因になることがわかりつつあるが、本研究の結果は、高食塩食のような体内浸透圧環境が変化するストレスが生体にどのように影響を与えるか理解し、薬などにより悪影響を取り除くための基盤的知見になると期待される。
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] ASK1 suppresses NK cell-mediated intravascular tumor cell clearance in lung metastasis.2021
Author(s)
Fujimoto, M., Kamiyama, M., Fuse, K., Ryuno, H., Odawara, T., Furukawa, N., Yoshimatsu, Y., Watabe, T., Michaela, P.-M., Veronika, S., Tahara, H., Hayakawa, Y., Sato, T., Takeda, K., Naguro, I. and Ichijo, H.
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Journal Title
Cancer Sci.
Volume: 112
Pages: 1633-1643
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu/Zn superoxide dismutase.2020
Author(s)
Homma, K., Takahashi, H., Tsuburaya, N., Naguro, I., Fujisawa, T. and Ichijo, H.
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Journal Title
Journal of Biological Chemistry
Volume: 295
Pages: 3148-3158
DOI
Related Report
Peer Reviewed / Open Access
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