|Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
|Outline of Final Research Achievements
Over 50 novel natural products were isolated from phytochemically untouched rainforest plants, elucidated their chemical structure, and evaluated for antiproliferative activity against tumor cell lines. The synthetic routs of bioactive natural products were developed, and various derivatives were synthesized. The structure-activity relationships and their mechanisms of action of bioactive derivatives were also investigated.