| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
We revealed importance of dopamine signaling in the amygdala in the regulation of REM sleep. We also found that glycinergic neurons in the ventral part of the medulla projecting to the anterior horn of the spinal cord are essential for hypotonia during REM sleep, and that these neurons are regulated by excitatory neurons from the SLD. These neurons are controlled by excitatory neurons from the SLD. We also showed that this pathway is involved in the expression of cataplexy. We also found that orexin and histamine neurons receive very similar inputs from the limbic system, reward system, and preoptic area. These two groups of neurons, which have a strong relationship, were shown to be similarly regulated in parallel.
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