| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
In this study, we identified two novel RING-type ubiquitin ligases (E3s), which bind and modulate LUBAC, a sole E3 to generate Met1-linked linear ubiquitin chain and activate NF-κB signaling. Among them, LUBAC-associated protein 1 (LAP1) suppressed LUBAC function and affected the cell death response, whereas LAP2 was found to further enhance NF-κB signal via K63 ubiquitination activity.
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