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Study on two ubiquitin ligases involved in inflammation and immune signal regulation

Research Project

Project/Area Number 18H02619
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 48040:Medical biochemistry-related
Research InstitutionOsaka City University

Principal Investigator

Tokunaga Fuminori  大阪市立大学, 大学院医学研究科, 教授 (00212069)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywordsタンパク質 / 酵素 / 細胞 / 炎症 / ユビキチン
Outline of Final Research Achievements

In this study, we identified two novel RING-type ubiquitin ligases (E3s), which bind and modulate LUBAC, a sole E3 to generate Met1-linked linear ubiquitin chain and activate NF-κB signaling. Among them, LUBAC-associated protein 1 (LAP1) suppressed LUBAC function and affected the cell death response, whereas LAP2 was found to further enhance NF-κB signal via K63 ubiquitination activity.

Academic Significance and Societal Importance of the Research Achievements

最近、ユビキチン鎖は均一の連結鎖で構成されるのではなく、分岐鎖や混合鎖など複数の連結鎖からなる複雑な形態を呈することで、多彩な細胞機能を微調節することが明らかになってきた。本研究で我々は、直鎖状ユビキチン鎖生成を介して炎症や免疫制御に重要なNF-κBシグナル経路を活性化するLUBACユビキチンリガーゼ(E3)と共役する2種の新規E3(LAP1とLAP2)を見出し、炎症・細胞死への影響を解明した。LUBACとLAP1、LAP2との相互作用は、炎症や細胞死を制御しており、神経変性疾患におけるユビキチン陽性封入体の経時的な凝集、タンパク質分解に対す抵抗性、炎症の遷延、細胞死に関わる可能性がある。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (65 results)

All 2022 2021 2020 2019 2018 2017 Other

All Journal Article (27 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 27 results,  Open Access: 16 results) Presentation (36 results) (of which Int'l Joint Research: 6 results,  Invited: 6 results) Remarks (2 results)

  • [Journal Article] Linear ubiquitination in immune and neurodegenerative diseases, and beyond2022

    • Author(s)
      Tokunaga Fuminori、Ikeda Fumiyo
    • Journal Title

      Biochemical Society Transactions

      Volume: 50 Issue: 2 Pages: 799-811

    • DOI

      10.1042/bst20211078

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion.2022

    • Author(s)
      Hieu VN, Thuy LTT, Hai H, Dat NQ, Hoang DV, Hanh NV, Phuong DM, Hoang TH, Sawai H, Shiro Y, Sato-Matsubara M, Oikawa D, Tokunaga F, Yoshizato K, Kawada N.
    • Journal Title

      Redox Biol.

      Volume: 52 Pages: 102286-102286

    • DOI

      10.1016/j.redox.2022.102286

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling2021

    • Author(s)
      Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
    • Journal Title

      Plos One

      Volume: - Issue: 3 Pages: e0248158-e0248158

    • DOI

      10.1371/journal.pone.0248158

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice2021

    • Author(s)
      Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
    • Journal Title

      Inflammation Research

      Volume: In press Issue: 5 Pages: 539-541

    • DOI

      10.1007/s00011-021-01458-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.2021

    • Author(s)
      Miyashita H, Oikawa D, Terawaki S, Kabata D, Shintani A, Tokunaga F.
    • Journal Title

      Frontiers in Immunology

      Volume: 12 Pages: 635475-635475

    • DOI

      10.3389/fimmu.2021.635475

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interplay between protein acetylation and ubiquitination controls MCL1 protein stability2021

    • Author(s)
      Shimizu Kouhei、Gi Min、Suzuki Shugo、North Brian J.、Watahiki Asami、Fukumoto Satoshi、Asara John M.、Tokunaga Fuminori、Wei Wenyi、Inuzuka Hiroyuki
    • Journal Title

      Cell Reports

      Volume: 37 Issue: 6 Pages: 109988-109988

    • DOI

      10.1016/j.celrep.2021.109988

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease2021

    • Author(s)
      Kuriyama Yuko、Shimizu Akira、Kanai Saki、Oikawa Daisuke、Motegi Sei-ichiro、Tokunaga Fuminori、Ishikawa Osamu
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 23146-23146

    • DOI

      10.1038/s41598-021-02522-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 6His-tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species2021

    • Author(s)
      Ninh Quoc Dat, Le Thi Thanh Thuy, Vu Ngoc Hieu, Fuminori Tokunaga, Massimo Pinzani, and Norifumi Kawada
    • Journal Title

      Hepatology

      Volume: 0-0 Issue: 6 Pages: 0-0

    • DOI

      10.1002/hep.31752

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis.2021

    • Author(s)
      Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Tokunaga F, Tsukagoshi H, Ishikawa O.
    • Journal Title

      Journal of American Academy of Dermatology

      Volume: 84 Issue: 4 Pages: 1103-1105

    • DOI

      10.1016/j.jaad.2020.05.051

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL2021

    • Author(s)
      Nakabayashi Osamu、Takahashi Hirotaka、Moriwaki Kenta、Komazawa-Sakon Sachiko、Ohtake Fumiaki、Murai Shin、Tsuchiya Yuichi、Koyahara Yuki、Saeki Yasushi、Yoshida Yukiko、Yamazaki Soh、Tokunaga Fuminori、Sawasaki Tatsuya、Nakano Hiroyasu
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 80-80

    • DOI

      10.1038/s42003-020-01603-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] cyclic GMP-AMP synthase (cGAS)2021

    • Author(s)
      徳永文稔
    • Journal Title

      アレルギー

      Volume: 70 Pages: 1239-1240

    • NAID

      130008115162

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 直鎖状ユビキチン鎖による炎症制御2021

    • Author(s)
      徳永文稔
    • Journal Title

      炎症と免疫

      Volume: 29 Pages: 201-208

    • NAID

      40020484741

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of linear ubiquitination in neurodegenerative diseases and development of LUBAC inhibitors2020

    • Author(s)
      及川 大輔、伊東 秀文、徳永 文稔
    • Journal Title

      生化学

      Volume: 92 Issue: 1 Pages: 28-34

    • DOI

      10.14952/SEIKAGAKU.2020.920028

    • ISSN
      0037-1017
    • Year and Date
      2020-02-25
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and application of a protein array of human deubiquitinating enzyme2020

    • Author(s)
      高橋宏隆、山中聡士、徳永文稔、澤崎達也
    • Journal Title

      生化学

      Volume: 92 Issue: 1 Pages: 64-74

    • DOI

      10.14952/SEIKAGAKU.2020.920064

    • ISSN
      0037-1017
    • Year and Date
      2020-02-25
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.2020

    • Author(s)
      Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
    • Journal Title

      Commun. Biol.

      Volume: 3 Issue: 1 Pages: 163-163

    • DOI

      10.1038/s42003-020-0882-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling2020

    • Author(s)
      Yamanaka Satoshi、Sato Yusuke、Oikawa Daisuke、Goto Eiji、Fukai Shuya、Tokunaga Fuminori、Takahashi Hirotaka、Sawasaki Tatsuya
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 524 Issue: 1 Pages: 1-7

    • DOI

      10.1016/j.bbrc.2019.12.049

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 創薬を見据えた直鎖状ユビキチン鎖生成酵素(LUBAC)阻害剤開発2020

    • Author(s)
      徳永 文稔
    • Journal Title

      Farumashia

      Volume: 56 Issue: 1 Pages: 26-30

    • DOI

      10.14894/faruawpsj.56.1_26

    • NAID

      130007779035

    • ISSN
      0014-8601, 2189-7026
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Linear Polyubiquitin Chain Modification of TDP-43-Positive Neuronal Cytoplasmic Inclusions in Amyotrophic Lateral Sclerosis2019

    • Author(s)
      Nakayama Yoshiaki、Tsuji Kazumi、Ayaki Takashi、Mori Megumi、Tokunaga Fuminori、Ito Hidefumi
    • Journal Title

      Journal of Neuropathology & Experimental Neurology

      Volume: 79 Issue: 3 Pages: 256-265

    • DOI

      10.1093/jnen/nlz135

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD2019

    • Author(s)
      Uematsu Atsushi、Kido Kohki、Takahashi Hirotaka、Takahashi Chikako、Yanagihara Yuta、Saeki Noritaka、Yoshida Shuhei、Maekawa Masashi、Honda Mamoru、Kai Tsutomu、Shimizu Kouhei、Higashiyama Shigeki、Imai Yuuki、Tokunaga Fuminori、Sawasaki Tatsuya
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 38 Pages: 14135-14148

    • DOI

      10.1074/jbc.ra119.010119

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of linear polyubiquitin chain immunoreactivity in tau pathology of Alzheimer’s disease2019

    • Author(s)
      Nakayama Yoshiaki、Sakamoto Shinji、Tsuji Kazumi、Ayaki Takashi、Tokunaga Fuminori、Ito Hidefumi
    • Journal Title

      Neuroscience Letters

      Volume: 703 Pages: 53-57

    • DOI

      10.1016/j.neulet.2019.03.017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling2019

    • Author(s)
      Katsuya Ken、Oikawa Daisuke、Iio Kiyosei、Obika Shingo、Hori Yuji、Urashima Toshiki、Ayukawa Kumiko、Tokunaga Fuminori
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 509 Issue: 3 Pages: 700-706

    • DOI

      10.1016/j.bbrc.2018.12.164

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 12018

    • Author(s)
      Kato Kazuki、Nishimasu Hiroshi、Oikawa Daisuke、Hirano Seiichi、Hirano Hisato、Kasuya Go、Ishitani Ryuichiro、Tokunaga Fuminori、Nureki Osamu
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 4424-4424

    • DOI

      10.1038/s41467-018-06922-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of Rat Monoclonal Antibodies Against a Deubiquitinase, Ovarian Tumor Domain-Containing Protein 12018

    • Author(s)
      Oikawa Daisuke、Shiota Masayuki、Goto Eiji、Komakura Keidai、Wanibuchi Hideki、Tokunaga Fuminori
    • Journal Title

      Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

      Volume: 37 Issue: 4 Pages: 180-184

    • DOI

      10.1089/mab.2018.0023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors Using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System2018

    • Author(s)
      Katsuya Ken、Hori Yuji、Oikawa Daisuke、Yamamoto Tomohisa、Umetani Kayo、Urashima Toshiki、Kinoshita Tomomi、Ayukawa Kumiko、Tokunaga Fuminori、Tamaru Masahiro
    • Journal Title

      SLAS DISCOVERY: Advancing Life Sciences R&D

      Volume: 23 Issue: 10 Pages: 1018-1029

    • DOI

      10.1177/2472555218793066

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of Rat Monoclonal Antibodies Specific for DZIP32018

    • Author(s)
      Oikawa Daisuke、Shiota Masayuki、Tokunaga Fuminori、Wanibuchi Hideki
    • Journal Title

      Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

      Volume: 37 Issue: 3 Pages: 153-157

    • DOI

      10.1089/mab.2018.0005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In-frame Val 216 -Ser 217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response2018

    • Author(s)
      Hattori Mai、Ishikawa Osamu、Oikawa Daisuke、Amano Hiroo、Yasuda Masahito、Kaira Kyoichi、Ishida-Yamamoto Akemi、Nakano Hajime、Sawamura Daisuke、Terawaki Shin-ichi、Wakamatsu Kaori、Tokunaga Fuminori、Shimizu Akira
    • Journal Title

      Journal of Dermatological Science

      Volume: 91 Issue: 1 Pages: 35-42

    • DOI

      10.1016/j.jdermsci.2018.03.012

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency2017

    • Author(s)
      Kuriyama Yuko、Hattori Mai、Mitsui Takeki、Nakano Hajime、Oikawa Daisuke、Tokunaga Fuminori、Ishikawa Osamu、Shimizu Akira
    • Journal Title

      J. Dermatol.

      Volume: - Issue: 5

    • DOI

      10.1111/1346-8138.14149

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 完全web形式での医学部1年生に対する遺伝カウンセリングロールプレイ2021

    • Author(s)
      馬場遥香, 浄弘裕紀子, 堀田純子, 徳永文捻, 瀬戸俊之
    • Organizer
      第44回日本遺伝カウンセリング学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 全身性エリテマトーデス、皮膚筋炎、自己免疫水泡症における協調したレトロトランスポゾンとⅠ型IFN経路の特徴2021

    • Author(s)
      栗山裕子、清水晶、金井早紀、及川大輔、徳永文稔、石川治、茂木精一郎
    • Organizer
      第68回北関東医学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A novel LUBAC-associated protein plays important roles in inflammatory response through regulation of programmed cell death2021

    • Author(s)
      Tran Thi Thuy Linh、清水康平、及川大輔、高橋宏隆、澤崎達也、徳永文稔
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] p300-mediated acetylation promotes MCL1 stabilization and tumorigenesis2021

    • Author(s)
      清水康平, 魏民, 鈴木周五, 徳永文稔, 犬塚博之, Wenyi Wei
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Identification of OTUD1 deubiquitinase as a regulator for innate immune responses, cell death, and inflammatory bowel disease2021

    • Author(s)
      Oikawa D, Gi M, Kosako H, Shimizu K, Shiota M, Takahashi H, Sawasaki T, Tokunaga F
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] HOIPIN-8, a chemical inhibitor for linear ubiquitination, suppresses ALS-related TDP-43 aggregation and inflammatory responses in neuronal cells2021

    • Author(s)
      Zhang Q, Terawaki S, Tokunaga F
    • Organizer
      第15回日本臨床ストレス応答学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] LUBACユビキチンリガーゼと直鎖状ユビキチン鎖が筋萎縮性側索硬化症関連タンパク質TDP-43の細胞質内凝集形成を促進する2021

    • Author(s)
      寺脇正剛, 張強, 及川大輔, 林邦忠, 布村一人, 駒川晋輔, 臼杵克之助, 徳永文稔
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 直鎖状ポリユビキチン鎖デコーダーZnUBPのNF-κBシグナル制御機構の解明2021

    • Author(s)
      岩崎誠, 長尾和哉, 及川大輔, 小迫英尊, 徳永文稔, 高橋宏隆, 澤崎達也
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脱ユビキチン化酵素USP15を特異的に阻害する低分子化合物の開発2021

    • Author(s)
      檜垣佳奈, 山中聡士, 佐藤裕介, 髙谷大輔, 本間光貴, 徳永文稔, 高橋宏隆, 澤崎達也
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A novel LUBAC-associated protein regulates NF-κB activation, apoptosis and necroptosis pathway2021

    • Author(s)
      清水康平, Tran Thi Thuy Linh, 及川大輔, 高橋宏隆, 澤崎達也, 徳永文稔
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Cellular functions regulated by complex-type ubiquitination including linear polyubiquitin chain2021

    • Author(s)
      Tokunaga F, Terawaki S, Oikawa D, Shimizu K
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] LRBA DUF1088ドメインの自然免疫制御における重要性2019

    • Author(s)
      及川大輔、駒倉啓大、福士雅也、入江崇、堀居拓郎、畑田出穂、阪口剛正、徳永文稔
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 直鎖状ポリユビキチン鎖結合タンパク質ZnUBPファミリーのNF-κB抑制機構の解明2019

    • Author(s)
      高橋宏隆、及川大輔、長尾和哉、岩崎誠、今井祐記、徳永文稔、澤崎達也
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脱ユビキチン化酵素OTUD1によるNF-κB経路とインターフェロン産生経路の相反的制御2019

    • Author(s)
      駒倉啓大、及川大輔、徳永文稔
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 直鎖状ユビキチン鎖生成を介した炎症シグナル発信と疾患・創薬2019

    • Author(s)
      徳永文稔
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Hsp72によるがん細胞遊走制御2019

    • Author(s)
      塩田正之、田中昌子、鰐渕英機、徳永文稔
    • Organizer
      第14回日本臨床ストレス応答学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] LUBACによるT細胞受容体シグナル制御に関する細胞・生化学及び数理モデル解析2019

    • Author(s)
      及川大輔、畑中尚也、鈴木貴、徳永文稔
    • Organizer
      第14回日本臨床ストレス応答学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Stress Signaling Modules: ストレスの受容と細胞応答の選択性 LUBACシグナルソームによる自然免疫応答の選択的制御2019

    • Author(s)
      及川 大輔, 駒倉 啓大, 阿部 貴則, 飯尾 清誠, 小比賀 真吾, 勝矢 健, 花田 和希, 坂本 信二, 徳永 文稔
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 自然免疫制御に関わる新規脱ユビキチン化酵素OTUD1の同定と生理機能解析2019

    • Author(s)
      駒倉啓大、徳永文稔
    • Organizer
      第24回日本病態プロテアーゼ学会学術集
    • Related Report
      2019 Annual Research Report
  • [Presentation] Screening and characterization of novel LUBAC inhibitors, HOIPINs2019

    • Author(s)
      Oikawa, D., Katsuya, K., Hanada, K., Sugawara, K., Tsuruta, D., Sakamoto, S., Tokunaga, F.
    • Organizer
      Cold Spring Harbor Laboratory Meeting on Ubiquitin, Autophagy & Disease
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cellular mechanism of LUBAC-mediated NF-κB activation pathway2019

    • Author(s)
      Fuminori Tokunaga
    • Organizer
      1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Screening and analysis of novel linear polyubiquitin chain binding proteins based on wheat cell-free 20K-HUPA2019

    • Author(s)
      Kazuya Nagano, Hirotaka Takahashi, Fuminori Tokunaga, Tatsuya Sawasaki
    • Organizer
      1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Subquinocin, a small moleculae inhibitor for USPs, promotes NF-κB signal by stabilization of M1-linked polyubiquitin2019

    • Author(s)
      Hirotaka Takahashi, Satoshi Yamanaka, Yusuke Sato, Daisuke Oikawa, Shuya Fukai, Fuminori Tokunaga, Tatsuya Sawasaki
    • Organizer
      1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification and characterization of small-molecule LUBAC inhibitors, HOIPINs2019

    • Author(s)
      Daisuke Oikawa, Ken Katsuya, Kazuya Hanada, Shinji Sakamoto, Fuminori Tokunaga
    • Organizer
      1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] OTUD1, and OTU family deubiquitinase, is involved in innate immune responses2019

    • Author(s)
      Keidai Komakura, Eiji Goto, Daisuke Oikawa, Takanori Abe, Fuminori Tokunaga
    • Organizer
      1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規LUBAC阻害剤、HOIPIN-1の作用機序と病態抑制効果2018

    • Author(s)
      及川大輔、花田和希、菅原弘二、寺脇正剛、水上裕加里、鶴田大輔、坂本信二、徳永文稔
    • Organizer
      第65回日本生化学会近畿支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] T細胞受容体を介したNF-κBシグナル制御の数理シミュレーション2018

    • Author(s)
      後藤栄治、浜田大輔、及川大輔、鈴木貴、徳永文稔
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] オートファジーアダプターNDP52による新規NF-κB・細胞死制御機構2018

    • Author(s)
      及川大輔、駒倉啓大、徳永文稔
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 直鎖状ユビキチン鎖生成酵素(LUBAC)に対する新規阻害剤の開発と炎症病態抑制2018

    • Author(s)
      及川大輔、花田和希、勝矢健、菅原弘二、水上裕加里、鶴田大輔、坂本信二、徳永文稔
    • Organizer
      第13回臨床ストレス応答学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] HSP72複合体の単離による血中微量タンパク質の同定2018

    • Author(s)
      塩田正之、田中昌子、鰐渕英機、徳永文稔
    • Organizer
      第13回臨床ストレス応答学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 自然免疫制御に関わる新規脱ユビキチン化酵素(OTUD1)の同定と生理機能解析2018

    • Author(s)
      駒倉啓大、後藤栄治、及川大輔、阿部貴則、徳永文稔
    • Organizer
      第13回臨床ストレス応答学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] TCRシグナルにおける直鎖状ユビキチン化の数理モデル解析2018

    • Author(s)
      後藤栄治、浜田大輔、及川大輔、鈴木貴、徳永文稔
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新規LUBAC阻害剤の探索と機能評価2018

    • Author(s)
      及川大輔、花田和希、勝矢健、菅原弘二、水上裕加里、鶴田大輔、坂本信二、徳永文稔
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] OTUD1は自然免疫制御に関わる脱ユビキチン化酵素である2018

    • Author(s)
      駒倉啓大、後藤栄治、及川大輔、阿部貴則、徳永文稔
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 自然免疫制御に関わる新規RING型E3(RNF126)の同定と機能解析2018

    • Author(s)
      阿部貴則、及川大輔、寺脇正剛、後藤栄治、高橋宏隆、大竹史明、川原裕之、堀居拓郎、畑田出穂、佐伯泰、田中啓二、澤崎達也、徳永文稔
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] コムギ無細胞系を用いて作製した脱ユビキチン化酵素(DUB)プロテインアレイによるポリユビキチン鎖基質特異性とDUB阻害剤の選択性評価2018

    • Author(s)
      高橋宏隆、山中聡士、桒田翔平、後藤栄治、今井賢一郎、富井健太郎、佐藤裕介、深井周也、徳永文稔、澤崎達也
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Remarks] 大阪市立大学大学院医学研究科分子病態学

    • URL

      http://osaka-cu-1seika.umin.jp

    • Related Report
      2020 Annual Research Report 2018 Annual Research Report
  • [Remarks] 大阪市立大学大学院医学研究科分子病態学HP

    • URL

      http://osaka-cu-1seika.umin.jp

    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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