| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
The immune system is an important biological defense system for protecting the body from pathogens, but abnormal autoreactive immune responses develop autoimmune diseases and inflammatory diseases. In this study, to develop a useful biomarker for autoreactive inflammatory cells and pathological evaluation of autoimmune disease, we established gene-modified mouse model expressing ubiquitous self-antigens (USAs-Tg). Using this model, we found that autoreactive CD8+ cells showed memory phenotype with PD-1+ Lag-3+ Tim-3+ CTLA-4-. In addition, the activation state of antigen-presenting cells affects the differentiation of inflammation-inducing cells.
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