Research Project
Grant-in-Aid for Scientific Research (B)
The purpose of this study was to analyze the function of C-type lectin Receptors (CLRs) using gene-deficient mice and find clues for the treatment of inflammatory diseases and cancers. We showed that CLRs play important roles in the development of colitis and colorectal tumors. Furthermore, we showed that Treg cells induced in DECTIN-1-deficient mouse colon through modification of intestinal microbiota suppress inflammation not only in the intestinal tract but also in lungs, suggesting that intestinal Tregs can migrate into other organs to suppress inflammation (Han et al., J. Immunol., 2021). We also analyzed the detailed mechanism of autoimmunity in DCIR-deficient mice, and showed that DC differentiation and antigen-presenting ability are enhanced in the mutant mice (Kaifu et al., under revision). From these analyses, we could show the roles of CLRs in inflammation and tumorigenesis and found clues to treat these diseases.
これまでの解析を基に、CLRファミリーメンバーの生体内での役割とその分子メカニズムを検討し、これらの分子が免疫制御や発癌制御に重要な役割を果たしていることを明らかにした。今後、これらの分子に対する抗体、阻害剤、促進剤などを用いて、自己免疫(関節リウマチや多発性硬化症)やアレルギー(喘息)、癌等に対する予防、治療薬の開発や、機能性食品の開発に繋げたい。
All 2021 2020 2019 2018
All Journal Article (49 results) (of which Int'l Joint Research: 27 results, Peer Reviewed: 49 results, Open Access: 21 results) Presentation (19 results) (of which Int'l Joint Research: 6 results, Invited: 7 results) Book (3 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 2 results)
Journal of Investigative Dermatology
Volume: 141 Pages: 164~176.e8
10.1016/j.jid.2020.04.030
Nature Communications
Volume: 12
10.1038/s41467-020-20307-9
Communications Biology
Volume: 4
10.1038/s42003-021-01902-y
European Journal of Immunology
10.1002/eji.202049010
The Journal of Immunology
Volume: 206 Pages: 1991~2000
10.4049/jimmunol.2001337
Biomedical Research
Volume: 42 Pages: 53~66
10.2220/biomedres.42.53
Proceedings of the National Academy of Sciences
Volume: 118
10.1073/pnas.2019798118
Cell Reports
Volume: 35 Pages: 109052~109052
10.1016/j.celrep.2021.109052
Translational and Regulatory Sciences
Volume: 2 Pages: 19~23
10.33611/trs.2_19
Volume: 205 Pages: 686~698
10.4049/jimmunol.1901238
Allergy
Volume: 75 Pages: 3216~3227
10.1111/all.14488
Frontiers in Immunology
Volume: 11
10.3389/fimmu.2020.01398
International Immunology
Volume: 33 Pages: 211~224
10.1093/intimm/dxaa071
Journal of Neurochemistry
10.1111/jnc.15235
Scientific Reports
Volume: 10
10.1038/s41598-020-63766-2
Volume: 10 Pages: 7047~7062
Volume: 10 Pages: 5692~5703
10.1038/s41598-020-62562-2
Cancer Immunology, Immunotherapy
Volume: 69 Pages: 115~126
10.1007/s00262-019-02445-2
American Journal of Physiology-Gastrointestinal and Liver Physiology
Volume: 318 Pages: G479~G489
10.1152/ajpgi.00208.2019
International Journal of Molecular Sciences
Volume: 20 Pages: 5657~5657
10.3390/ijms20225657
Journal of Allergy and Clinical Immunology
Volume: 144 Pages: 1036~1049
10.1016/j.jaci.2019.06.019
Volume: 9 Pages: 10602~10615
10.1038/s41598-019-46968-1
Volume: 9 Pages: 9608~9621
10.1038/s41598-019-45653-7
Journal of Clinical Investigation
Volume: 129 Pages: 3610~3624
10.1172/JCI123778
Frontiers in Systems Neuroscience
Volume: 13 Pages: 1~15
10.3389/fnsys.2019.00018
Nature Immunology
Volume: 20 Pages: 559~570
10.1038/s41590-019-0377-2
Molecular and Cellular Biology
Volume: 39 Pages: 18~35
10.1128/MCB.00586-18
Journal of Leukocyte Biology
Volume: 106 Pages: 903~917
10.1002/JLB.2RI0119-031R
Volume: 74 Pages: 1920~1933
10.1111/all.13801
Biological and Pharmaceutical Bulletin
Volume: 42 Pages: 543~546
10.1248/bpb.b18-00363
Biochemical and Biophysical Research Communications
Volume: 511 Pages: 330~335
10.1016/j.bbrc.2019.02.046
The Journal of investigative dermatology
Volume: 139 Pages: 702-711
10.1016/j.jid.2018.10.015
Mucosal immunology
Volume: 12 Pages: 265-276
10.1038/s41385-018-0094-4
Circulation
Volume: 139 Pages: 663-678
10.1161/CIRCULATIONAHA.118.036044
The Journal of clinical investigation
Volume: 128 Pages: 5399-5412
10.1172/JCI121901
International Journal of Cardiology
Volume: 270 Pages: 221-227
10.1016/j.ijcard.2018.05.072
Biochemical and biophysical research communications
Volume: 506 Pages: 429-436
10.1016/j.bbrc.2018.10.104
Scientific reports
Volume: 8 Pages: 15783
10.1038/s41598-018-34173-5
Immunology
Volume: 155 Pages: 418-426
10.1111/imm.12993
Nature communications
Volume: 9 Pages: 3350
10.1038/s41467-018-05202-8
iScience
Volume: 6 Pages: 306-318
10.1016/j.isci.2018.08.007
Volume: 11 Pages: 1127-1137
10.1038/s41385-018-0023-6
Journal of immunology (Baltimore, Md. : 1950)
Volume: 201 Pages: 167-182
10.4049/jimmunol.1701157
Science advances
Volume: 4 Pages: 9944
10.1126/sciadv.aas9944
Microbes and infection
Volume: 21 Pages: 33-39
10.1016/j.micinf.2018.06.006
Nature immunology
Volume: 19 Pages: 755-765
10.1038/s41590-018-0134-y
J. Allergy Clin. Immunol
Volume: 142 Pages: 1500-1509
10.1016/j.jaci.2017.12.1007.
Cancer Res.
Volume: 78 Pages: 2040-2051
10.1158/0008-5472.
Mucosal Immunol
Volume: 11 Pages: 763-773
10.1038/mi.2017.86.