Induction of Cancer Stem Cell Properties by GPNMB
Project/Area Number |
18H02676
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 50010:Tumor biology-related
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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Keywords | がん / がん幹細胞 / Glycoprotein NMB / 細胞増殖動態 / 休眠がん細胞 / 乳癌 / GPNMB / 乳がん / 腫瘍形成能 / リン酸化 / 休眠期がん細胞 / 抗体 |
Outline of Final Research Achievements |
Cancer is characterized by the continuous increase of total cell numbers. However, drug resistance, metastasis and recurrence, which cause poor outcome of cancer patients, depend on the small numbers of growth-arrested cancer stem cells. In this research, GPNMB was shown to be exposed on the cell surface of growth arrested breast cancer cells and induces stem cell properties. This discovery elucidated the essential role of GPNMB in growth arrested breast cancer cells to promote tumorigenic growth of cancer cells. Therefore, it is expected to contribute the development of a novel cancer therapy which can target cancer cells initiating metastasis and recurrence.
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Academic Significance and Societal Importance of the Research Achievements |
本研究は、増殖が停止したがん細胞が、がん細胞集団の持続的増殖をもたらすことを示している。これによりがん細胞が増殖停止状態と細胞周期を回っている状態を移行しながら持続的増殖を示すという細胞増殖動態が示唆され、転移や再発に寄与する分子機構であることから、進行して転移や再発を起こしたがんの治療も可能にする新たな分子標的治療の開発につながることが期待される。また、この病理発生機序は、多くのがんで共通に働いているため、特定のがん遺伝子産物を標的とする従来のがん治療に比べ多くのがん患者に適用できる治療法となることが期待される。
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Report
(4 results)
Research Products
(22 results)
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[Presentation] The roles of TMEPAI in breast cancer cells2018
Author(s)
Meidi Utami Puteri, Bantari Wisynu Kusuma Wardhani, Riezki Amalia, Mohammed Abdelaziz, Yukihide Watanabe and Mitsuyasu Kato
Organizer
The 3rd International Conference on Advance Pharmacy and Pharmaceutical Sciences
Related Report
Int'l Joint Research
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