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Development of therapeutic miRNAs targeting BET family protein BRD4 for cancer

Research Project

Project/Area Number 18H02688
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 50020:Tumor diagnostics and therapeutics-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Inazawa Johji  東京医科歯科大学, 難治疾患研究所, 教授 (30193551)

Co-Investigator(Kenkyū-buntansha) 井上 純  東京医科歯科大学, 難治疾患研究所, 准教授 (50568326)
玄 泰行  東京医科歯科大学, 難治疾患研究所, 助教 (80596156)
村松 智輝  東京医科歯科大学, 難治疾患研究所, 助教 (90732553)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
KeywordsマイクロRNA / 抗癌性核酸医薬 / BETファミリー蛋白 / BRD4 / DNA修復経路 / miR-1293 / miR-3140-3p / スーパーエンハンサー / 核酸医薬 / 抗がん核酸製剤 / BETファミリーBRD4 / DNA損傷修復 / BETファミリ-蛋白
Outline of Final Research Achievements

Base on the data from our proliferation assay using a 2,565 human miR library, we identified miR-1293 and miR-3140-3p as a tumor suppressor miRNA (TS-miR), Those TS-miRs have significant growth inhibitory effects targeting BRD4. miR-1293 also targeted DNA repair pathway genes such as APEX1, RPA1, and POLD4. With the exogenous expression of miR-1293, DNA-damage repair was significantly reduced, and antitumor effects were demonstrated in in vitro/vivo. On the other hand, in addition to the suppression of BRD4, miR-3140-3p reduced MYCN expression by targeting the MAP3K3-ERK1/2 pathway and showed strong growth suppression even in BET inhibitor-resistant NB cells. These results indicate that miR-1293 and miR-3140-3p may be promising seeds for nucleic acid anticancer drugs.

Academic Significance and Societal Importance of the Research Achievements

分子標的治療薬の問題点の一つに薬剤耐性の獲得が知られています。その克服を目指し、次世代型の医薬品として癌抑制型マイクロRNA(miR)核酸抗癌薬の開発が注目されています。本研究では、2565種類のヒトmiRの中から強い抗腫瘍効果を示すmiR-1293とmiR-3140-3pを同定しました。ともにBRD4を標的にその機能を抑制します。さらにmiR-1293はDNA修復経路の複数遺伝子を標的にして機能を抑制することでDNA損傷蓄積と強い抗腫瘍効果が導かれることを発見しました。今後、これらの癌抑制型miRを用いた核酸抗癌薬の開発は難治癌の新たな治療戦略として期待されます。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(68 results)

All 2021 2020 2019 2018

All Journal Article (16 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 16 results,  Open Access: 15 results) Presentation (45 results) (of which Int'l Joint Research: 10 results,  Invited: 13 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 4 results)

  • [Journal Article] Augmentation of lenvatinib efficacy by topical treatment of miR-634 ointment in anaplastic thyroid cancer2021

    • Author(s)
      Kishikawa Masahiro, Inoue Jun, Hamamoto Hidetoshi, Kobayashi Katsunori, Asakage Takahiro, Inazawa Johji
    • Journal Title

      Biochem Biophys Rep.

      Volume: 26 Pages: 101009-101009

    • DOI

      10.1016/j.bbrep.2021.101009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma2021

    • Author(s)
      Inoue Jun、Kishikawa Masahiro、Tsuda Hitoshi、Nakajima Yasuaki、Asakage Takahiro、Inazawa Johji
    • Journal Title

      Cancer Science

      Volume: -

    • DOI

      10.1111/cas.14938

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of MET Signaling Mediated by Pitavastatin and Capmatinib Inhibits Oral and Esophageal Cancer Cell Growth2020

    • Author(s)
      Xu Bo、Muramatsu Tomoki、Inazawa Johji
    • Journal Title

      Molecular Cancer Research

      Volume: 19 Pages: 585-597

    • DOI

      10.1158/1541-7786.mcr-20-0688

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improving the Efficacy of EGFR Inhibitors by Topical Treatment of Cutaneous Squamous Cell Carcinoma with miR-634 Ointment2020

    • Author(s)
      Inoue Jun、Fujiwara Kyoko、Hamamoto Hidetoshi、Kobayashi Katsunori、Inazawa Johji
    • Journal Title

      Molecular Therapy Oncolytics

      Volume: 19 Pages: 294-307

    • DOI

      10.1016/j.omto.2020.10.009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Large-scale genome-wide association study in a Japanese population identifies novel susceptibility lociacross different diseases2020

    • Author(s)
      Ishigaki K, Akiyama M, Kohno T, Shiraishi K, Momozawa Y, Matsuda K, Daigo Y, Kubo M, Kamatani Y.
    • Journal Title

      Nature Genetics

      Volume: 52 Pages: 669-679

    • DOI

      10.1038/s41588-020-0640-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway2020

    • Author(s)
      Takagawa Yuki、Gen Yasuyuki、Muramatsu Tomoki、Tanimoto Kousuke、Inoue Jun、Harada Hiroyuki、Inazawa Johji
    • Journal Title

      Molecular Therapy

      Volume: 28 Pages: 1494-1505

    • DOI

      10.1016/j.ymthe.2020.04.001

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic Potential of LNP-Mediated Delivery of miR-634 for Cancer Therapy2020

    • Author(s)
      Gokita K, Inoue J, Ishihara H, Kojima K, Inazawa J
    • Journal Title

      Molecular Therapy - Nucleic Acids

      Volume: 19 Pages: 330-338

    • DOI

      10.1016/j.omtn.2019.10.045

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population2019

    • Author(s)
      Low SK, Chin YM, Ito H, Matsuo K, Tanikawa C, Matsuda K, Saito H, Nakaya N, Shimizu A, Murakami Y, Inazawa J, Nakamura Y, Kubo M, Katagiri T, Miki Y.
    • Journal Title

      Sci Rep

      Volume: 9 Pages: 17332-17332

    • DOI

      10.1038/s41598-019-53654-9

    • NAID

      120006875665

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Massive computational identification of somatic variants in exonic splicing enhancers using The Cancer Genome Atlas2019

    • Author(s)
      Tanimoto Kousuke、Muramatsu Tomoki、Inazawa Johji
    • Journal Title

      Cancer Medicine

      Volume: 8 Pages: 7372-7384

    • DOI

      10.1002/cam4.2619

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population2019

    • Author(s)
      Takata Ryo、Takahashi Atsushi、Fujita Masashi et al.
    • Journal Title

      Nature Communications

      Volume: 10 Pages: 4422-4422

    • DOI

      10.1038/s41467-019-12267-6

    • NAID

      120006731132

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer2019

    • Author(s)
      Ryoko Kikuchi-Koike, Kazunori Nagasaka, Hitoshi Tsuda, Yasuyuki Ishii, Masaru Sakamoto, Yoshihiro Kikuchi, Shiho Fukui, Yuko Miyagawa, Haruko Hiraike, Takayuki Kobayashi, Takayuki Kinoshita, Yae Kanai, Tatsuhiro Shibata, Issei Imoto, Johji Inazawa, Osamu Matsubara and Takuya Ayabe
    • Journal Title

      BMC Cancer

      Volume: 19 Pages: 521-521

    • DOI

      10.1186/s12885-019-5737-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fibroblast growth factor signals regulate transforming growth factor-β-induced endothelial-to-myofibroblast transition of tumor endothelial cells via Elk12019

    • Author(s)
      Akatsu Y*, Takahashi N*, Yoshimatsu Y*, Kimuro S, Muramatsu T, Katsura A, Maishi N, Suzuki HI, Inazawa J, Hida K, Miyazono K, Watabe T. (*equal contribution)
    • Journal Title

      Mol Oncol.

      Volume: 13 Pages: 1706-1724

    • DOI

      10.1002/1878-0261.12504

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide association study identifies gastric cancer susceptibility loci at 12q24. 11-12 and 20q11. 212018

    • Author(s)
      Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, Momozawa Y, Hirata M, Fuse N, Takai-Igarashi T, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Hishida A, Wakai K, Furusyo N, Murakami Y, Nakamura Y, Imoto I, In
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 12 Pages: 4015-4024

    • DOI

      10.1111/cas.13815

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification and characterization of transforming growth factor beta-induced in circulating tumor cell subline from pancreatic cancer cell line2018

    • Author(s)
      Sato Taku、Muramatsu Tomoki、Tanabe Minoru、Inazawa Johji
    • Journal Title

      Cancer Science

      Volume: 109 Pages: 3623-3633

    • DOI

      10.1111/cas.13783

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein2018

    • Author(s)
      Tonouchi Erina、Gen Yasuyuki、Muramatsu Tomoki、Hiramoto Hidekazu、Tanimoto Kousuke、Inoue Jun、Inazawa Johji
    • Journal Title

      Sci Rep.

      Volume: 8 Pages: 4482-4482

    • DOI

      10.1038/s41598-018-22767-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ovarian cancer therapeutic potential of glutamine depletion based on GS expression.2018

    • Author(s)
      Furusawa A, Miyamoto M, Takano M, Tsuda H, Song YS, Aoki D, Miyasaka N, Inazawa J, Inoue J.
    • Journal Title

      Carcinogenesis

      Volume: 印刷中 Pages: 758-766

    • DOI

      10.1093/carcin/bgy033

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] microRNAs therapeutics in precision cancer medicine (PCM)2020

    • Author(s)
      Inazawa J.
    • Organizer
      The 4th Annual Meeting of International Society of Precision Cancer Medicine Virtual Meeting (ISPCM20200)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 癌ゲノム学入門:がん精密医療を実践するために知っておきたい遺伝学の知識(オンデマンド配信)2020

    • Author(s)
      稲澤譲治
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] MYC 経路を標的とする新規腫瘍抑制型 miRNA の同定2020

    • Author(s)
      玄泰行、稲澤譲治
    • Organizer
      第24回日本がん分子標的治療学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] がんと遺伝性疾患のゲノム・エピゲノム解析研究から見えてきたもの2020

    • Author(s)
      稲澤譲治
    • Organizer
      第1回 せとうち臨床遺伝研究会
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Invited
  • [Presentation] 口腔・食道がんにおいてピタバスタチンは AKT、ERK のシグナルを抑制し、細胞増殖を阻害する2020

    • Author(s)
      村松智輝、徐博、稲澤譲治
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 日本人前立腺癌の発癌に関する新規 12 遺伝子多型とポリジェニックリスクスコアの同定2020

    • Author(s)
      高田亮、赤松秀輔、中川英刀、高橋篤、頴川晋、鎌谷洋一郎、稲澤譲治、小川修、小原航
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食道癌における治療標的としての代謝関連分子の探索2020

    • Author(s)
      井上純、岸川正大、朝蔭孝宏、稲澤譲治
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] miR-3140はBRD4-MYCN 経路を標的とし、神経芽腫細胞の増殖を抑制する2020

    • Author(s)
      劉暢、玄泰行、稲澤譲治
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] MYC 経路を標的とする新規腫瘍抑制型 miRNA を用いた核酸抗癌薬の可能性2020

    • Author(s)
      玄泰行、稲澤譲治
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] LNP を介した miR-634 の腫瘍への送達による抗腫瘍効果2020

    • Author(s)
      井上純、稲澤譲治
    • Organizer
      第24回日本がん分子標的治療学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] FDA承認薬ライブラリーから見出したピタバスタチンの抗腫瘍効果についての機能解析2020

    • Author(s)
      村松智輝、稲澤譲治
    • Organizer
      第24回日本がん分子標的治療学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] microRNAs therapeutics in precision cancer medicine (PCM)2020

    • Author(s)
      Inazawa J
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] microRNAs therapeutics in personalized cancer medicine (PCM)2019

    • Author(s)
      Inazawa J
    • Organizer
      10th International Conference on Nutrition and Physical Activity in Aging, Obesity and Cancer
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] microRNA therapeutics in Precision Cancer Medicine2019

    • Author(s)
      Inazawa J
    • Organizer
      2019 The International Conference of Food Safety and Health
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] MicroRNA Therapeutics in cancer2019

    • Author(s)
      Inazawa J
    • Organizer
      International Ovarian Cancer Research Consortium and International Symposium on Tumor Microenvironment
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Therapeutic potential of the topical treatment of miR-634 ointment for cutaneous squamous cell carcinoma2019

    • Author(s)
      Inoue J, Gokita K, Kishikawa M, Hamamoto H, Kobayashi K, Fujiwara K, Asakage T, Kojima K, Inazawa J
    • Organizer
      AACR Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification and characterization of TGFBI in circulating tumor cell subline from pancreatic cancer cell line2019

    • Author(s)
      Muramatsu T, Sato T, Tanabe M, Inazawa J
    • Organizer
      AACR Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がん抑制型マイクロRNAの探索と核酸抗がん薬の開発2019

    • Author(s)
      稲澤譲治
    • Organizer
      第15回 難病・遺伝医学セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 健康と医療のために知っておきたいゲノム研究最前線2019

    • Author(s)
      稲澤譲治
    • Organizer
      平成31年度さいたま市民大学 教養Ⅰコース 人生 100 年時代これからの新しい教養~テクノロジー・未来編~
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 統合的 mRNA, miRNA 発現情報を基盤とした独自のマイクロ RNA標的遺伝子予測データベースの構築2019

    • Author(s)
      内藤諒、村松智輝、谷本幸介、稲澤譲治
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 皮膚扁平上皮癌における miR-634 軟膏による抗腫瘍効果2019

    • Author(s)
      井上純、岸川正大、濱本英利、小林勝則、藤原恭子、稲澤譲治
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新規癌抑制型 miRNA による MYC 標的核酸抗癌治療の可能性2019

    • Author(s)
      玄泰行、村松智輝、井上純、稲澤譲治
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 甲状腺未分化癌に対する miR-634 を用いた核酸抗癌剤の開発2019

    • Author(s)
      岸川正大、井上純、濱本英利、小林勝則、朝蔭孝宏、稲澤譲治
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] miR-3140 は BRD4-MYCN 経路を標的とし、神経芽腫細胞の増殖を抑制する2019

    • Author(s)
      劉暢、玄泰行、稲澤譲治
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 扁平上皮がん細胞においてピタバスタチンは AKT、ERK の抑制を介して細胞増殖を阻害する2019

    • Author(s)
      徐博、村松智輝、稲澤譲治
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 線維芽細胞増殖因子(FGF2)は腫瘍血管内皮細胞において TGF-b によって誘導される内皮-筋線維芽移行を制御する2019

    • Author(s)
      吉松康裕、赤津裕一、高橋直也、紀室志織、村松智輝、桂彰宏、間石奈湖、鈴木洋、稲澤譲治、樋田京子、宮園浩平、渡部徹郎
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 循環腫瘍細胞亜株 (Panc-1-CTC)の発現解析から見出した TGFBIの機能解析2019

    • Author(s)
      村松智輝、佐藤拓、田邉稔、稲澤譲治
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 機能的 miRNA ライブラリースクリーニングによる、BRD4 を標的とする新規癌抑制型 miRNA の同定2019

    • Author(s)
      高川祐希、玄泰行、村松智輝、原田浩之、稲澤譲治
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 膵臓癌細胞株(Panc-1)から樹立したCTC 亜株における TGFBI の機能解析2019

    • Author(s)
      村松智輝、稲澤譲治
    • Organizer
      第23回日本がん分子標的治療学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 核酸抗癌薬を目指した新規腫瘍抑制型 miRNA の探索2019

    • Author(s)
      玄泰行、村松智輝、井上純、稲澤譲治
    • Organizer
      第23回日本がん分子標的治療学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Exploring novel cancer-related microRNAs and their diagnostic and therapeutic potentials in Personalized Cancer Medicine (PCM)2019

    • Author(s)
      Inazawa J
    • Organizer
      The 3rd International Symposium of International Society of Precision Cancer Medicine 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Therapeutic potential of LNP-mediated delivery of miR-634 for cancer therapy2019

    • Author(s)
      Inoue J, Gokita K, Kojima K, Inazawa J
    • Organizer
      The 3rd International Symposium of International Society of Precision Cancer Medicine 2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] Therapeutic potential of the topical treatment of miR-634 ointment for skin cancer.2019

    • Author(s)
      Kishikawa M, Inoue J, Asakage T, Inazawa J
    • Organizer
      The 3rd International Symposium of International Society of Precision Cancer Medicine 2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] The exploration of novel tumor suppressive miRNAs using function-based miRNA screening2019

    • Author(s)
      Gen Y, Inoue J, Inazawa J
    • Organizer
      The 3rd International Symposium of International Society of Precision Cancer Medicine 2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] Exploring novel tumor suppressive microRNAs in OSCC2019

    • Author(s)
      Takagawa Y, Gen Y, Muramatsu T, Harada H, Inazawa J.
    • Organizer
      The 3rd International Symposium of International Society of Precision Cancer Medicine 2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] Exploring novel cancer-related microRNAs and their diagnostic and therapeutic potentials in Precision Cancer Medicine (PCM).2018

    • Author(s)
      Inazawa J
    • Organizer
      TMU-TMDU Joint Symposium 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exploring novel cancer-related microRNAs and their diagnostic and therapeutic potentials in Personalized Cancer Medicine (PCM)2018

    • Author(s)
      Inazawa J
    • Organizer
      IUBMB SEOUL 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein2018

    • Author(s)
      Muramatsu T, Tonouchi E, Gen Y, Hiramoto H, Tanimoto K, Inoue J, Inazawa J
    • Organizer
      AACR Annual Meeting 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Ovarian cancer therapeutic potential of glutamine depletion based on GS expression2018

    • Author(s)
      Furusawa A, Inoue J, Miyamoto M, Takano M, Tsuda H, Song YS, Aoki D, Miyasaka N, Inazawa J
    • Organizer
      AACR Annual Meeting 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] LNPを介したmiR-634の送達による抗腫瘍効果2018

    • Author(s)
      五木田憲太郎、井上純、石原比呂之、小嶋一幸、稲澤譲治
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] グルタミン合成酵素の発現に基づいた細胞外グルタミン枯渇による卵巣がん治療戦略の開発2018

    • Author(s)
      井上純、古澤啓子、宮本守員、高野政志、津田均、Song Yong Sang、青木大輔、宮坂尚幸、稲澤譲治
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 口腔扁平上皮癌における新規のがん抑制型マイクロRNAの探索2018

    • Author(s)
      髙川祐希、玄泰行、村松智輝、原田浩之、稲澤譲治
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 日本人における前立腺癌の発症に関連する14遺伝子領域の同定2018

    • Author(s)
      高田亮、赤松秀輔、中川英刀、高橋篤、寺田直樹、加藤陽一郎、兼平貢、杉村淳、稲澤譲治、小川修、小原航
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 機能的miRNAスクリーニングを用いた、p53不活性型癌に細胞死を誘導するmiRNAの探索2018

    • Author(s)
      玄泰行、井上純、稲澤譲治
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 皮膚癌に対するmiR-634軟膏の塗布による抗腫瘍効果2018

    • Author(s)
      岸川正大、井上純、濱本英利、小林勝則、藤原恭子、朝蔭孝宏、稲澤譲治
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 医薬組成物2020

    • Inventor(s)
      稲澤 譲治、玄 泰之、井上 純、村松 智輝、高川 祐希
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] がん用医薬組成物2020

    • Inventor(s)
      稲澤 譲治、村松 智輝、徐 博
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-107768
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 医薬組成物2019

    • Inventor(s)
      稲澤 譲治、玄 泰之、井上 純、村松 智輝、高川 祐希
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-233250
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] マイクロRNAの測定方法、並びに、がん治療剤及びこれを含有するがん治療のための医薬組成物2018

    • Inventor(s)
      稲澤譲治、井上純、山本信祐、河野辰幸、小崎健一
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-094747
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] マイクロRNAの測定方法、並びに、がん治療剤及びこれを含有するがん治療のための医薬組成物2018

    • Inventor(s)
      稲澤譲治、井上純、山本信祐、河野辰幸、小崎健一
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] マイクロRNA及びその誘導体を有効成分とする医薬組成物2018

    • Inventor(s)
      稲澤譲治、玄泰行、村松智輝、外内えり奈
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] マイクロRNA及びその誘導体を有効成分とする医薬組成物2018

    • Inventor(s)
      稲澤譲治、玄泰行、村松智輝、外内えり奈
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas

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Published: 2018-04-23   Modified: 2022-01-27  

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