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恐怖記憶を支える皮質感覚野機序の解明

Research Project

Project/Area Number 18H02714
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 51020:Cognitive and brain science-related
Research InstitutionKeio University

Principal Investigator

小泉 愛  慶應義塾大学, 政策・メディア研究科(藤沢), 特任講師 (60588953)

Co-Investigator(Kenkyū-buntansha) 戸田 裕之  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 精神科学, 准教授 (00610677)
柴田 和久  国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (20505979)
土谷 尚嗣  株式会社国際電気通信基礎技術研究所, 脳情報通信総合研究所, 客員研究員 (80517128)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords恐怖記憶 / 皮質 / 感覚野 / VR / 身体運動 / トラウマ / 視覚 / fMRI / モーショントラック / 皮質メカニズム / PTSD / 脳構造 / 恐怖 / 知覚 / 記憶 / 視覚野
Outline of Annual Research Achievements

当該年度では、トラウマ経験が感覚野や前頭前野の連携を通して長期記憶化するメカニズムを健常者を対象とした基礎研究のデータ解析を通して明らかにした。さらに、実際の交通事故トラウマを経験した人を対象としたPTSD発症に寄与する脳活動や脳体積の特性を明らかにするための研究体制を構築しデータ収集を推進した。加えて、VRやモーションキャプチャを活用してトラウマ経験の記憶や克服を身体運動から捉えることに成功し、研究開発面においても大いに進展した。

Research Progress Status

令和3年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和3年度が最終年度であるため、記入しない。

Report

(4 results)
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(14 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (1 results)

  • [Int'l Joint Research] Monash University(オーストリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Maastricht University(オランダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Maastricht University(オランダ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A reciprocal inhibition model of alternations between non-dissociative and dissociative states in patients with PTSD2021

    • Author(s)
      Chiba, T., Ide, K., Boku, S., Taylor, J.E., Ph.D., Toda, H., Kanazawa, T., Kato, S., Horiuchi, Y. Hishimoto, A., Maruyama, T. Yamamoto, T., Shirakawa, M., Sora, I., Kawato, M., and *Koizumi, A.
    • Journal Title

      Molecular Psychiatry

      Volume: 26 Pages: 5023-5039

    • DOI

      10.1038/s41380-020-0827-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Atypical spatial frequency dependence of visual metacognition among schizophrenia patients2020

    • Author(s)
      Koizumi Ai、Hori Tomoki、Maniscalco Brian、Hayase Makoto、Mishima Ryou、Kawashima Takahiko、Miyata Jun、Aso Toshihiko、Lau Hakwan、Takahashi Hidehiko、Amano Kaoru
    • Journal Title

      NeuroImage: Clinical

      Volume: 27 Pages: 102296-102296

    • DOI

      10.1016/j.nicl.2020.102296

    • NAID

      120006949375

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Threat anticipation in pulvinar and in superficial layers of primary visual cortex (V1). Evidence from layer-specific ultra-high field 7T fMRI.2019

    • Author(s)
      Koizumi A, Zhan M, Ban H, Kida I, De Martino FJ, Vaessen M, de Gelder B & Amano K
    • Journal Title

      eneuro

      Volume: 6 Pages: 0429-19

    • DOI

      10.1523/eneuro.0429-19.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Layer-specific ultra-high field 7T fMRI showing that threat anticipation is mediated by the pulvinar input to the superficial layers of primary visual cortex (V1)2018

    • Author(s)
      Ai Koizumi, Minye Zhan, Hiroshi Ban, Ikuhiro Kida, Federico de Martino, Maarten Vaessen, Beatrice de Gelder, Kaoru Amano
    • Journal Title

      BioRxiv

      Volume: October 2

    • DOI

      10.1101/431270

    • Related Report
      2018 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Presentation] Emergence and regulation of fear - from mouse behavior to human imagination2022

    • Author(s)
      Koizumi Ai
    • Organizer
      日本神経科学学会大会
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 厄介で素晴らしき不安な脳の働き2021

    • Author(s)
      小泉愛
    • Organizer
      日本神経科学学会大会
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳から考える心身の痛み・慢性疼痛とその予防・ヘルスケア2021

    • Author(s)
      小泉愛
    • Organizer
      CANS応用脳コンソーシアム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 不安と恐怖の脳科学2021

    • Author(s)
      小泉愛
    • Organizer
      早稲田大学心理学セミナーシリーズ
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Integrating diverse events to form holistic fear memories in the human brain2020

    • Author(s)
      Ai Koizumi、Aurelio Cortese、Ryu Ohata、Norimichi Kitagawa、Hiroshi Imamizu
    • Organizer
      日本神経科学大会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pulvinar modulates primary visual cortex in a laminar dependent manner during perception of fear2018

    • Author(s)
      Ai Koizumi, Minye Zhan, Hiroshi Ban, Ikuhiro Kida, Federico de Martino, Maarten Vaessen, Beatrice de Gelder, Kaoru Amano
    • Organizer
      The social & affective neuroscience society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Book] fMRI Neurofeedback2021

    • Author(s)
      Ai Koizumi, Mitsuo Kawato
    • Publisher
      Elsevier
    • ISBN
      9780128224212
    • Related Report
      2021 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-12-28  

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