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Molecular mechanism of organelle crosstalk on organ homeostasis in aging and disease

Research Project

Project/Area Number 18H02727
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionThe University of Tokyo

Principal Investigator

Inagi Reiko  東京大学, 医学部附属病院, 特任教授 (50232509)

Co-Investigator(Kenkyū-buntansha) 平川 陽亮  東京大学, 医学部附属病院, 助教 (10780736)
井上 剛  東京大学, 医学部附属病院, 特任助教 (30821665)
南学 正臣  東京大学, 医学部附属病院, 教授 (90311620)
田中 哲洋  東京大学, 医学部附属病院, 准教授 (90508079)
西 裕志  東京大学, 医学部附属病院, 講師 (90784174)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords小胞体ストレス / ミトコンドリアストレス / オルガネラストレス / 一次繊毛 / 尿細管脂質代謝 / 尿細管炎症 / オルガネラ間相互作用 / 尿細管細胞代謝 / オルガネラクロストーク / IFT88 / 慢性腎臓病 / ミトコンドリアDNA / cGAS-STING経路 / 急性腎不全 / エネルギー代謝 / 脂質代謝 / 脂質毒性 / ATF6 / 尿細管間質線維化
Outline of Final Research Achievements

We investigated the effect of organelle crosstalk in the renal metabolism homeostasis and chronic inflammation, both of which closely contribute to aging phenotype and aging-related metabolic diseases in the kidney.
Firstly, we focused on the link between tubulointerstitial fibrosis and lipid metabolic alteration in chronic kidney disease and demonstrated that ATF6α, a transcription factor of the unfolded protein response, regulates proximal tubular cell fatty acid metabolism, contributing to lipotoxicity-induced tubulointerstitial fibrosis. Secondly, we focused on acute kidney injury that is characterized by mitochondrial dysfunction and tubular inflammation and demonstrated that mitochondrial dysfunction and subsequent activation of the mitochondrial DNA-cGAS-STING pathway is a critical regulator of tubular injury. Lastly, we found the pathogenic link between mitochondrial metabolic damage and decreased expression of primary cilial component (IFT88) associated with cilia shortening.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は日本腎臓学会、国際学会(アメリカ腎臓学会、アジア太平洋腎臓学会、国際腎臓学会)において招待講演、YIA受賞講演、一般演題口頭発表、ポスターセッションにて発表がなされ、活発に議論された。
また研究成果の一部は、国際英文雑誌に掲載 (Kidney Int, Cell Rep, など19報) 、あるいは現在投稿中である。
一連の学術的活動は、腎臓病の新規病態生理学メカニズムをオルガネラ間相互作用の視点から明らかにし、それに基づく革新的診断・治療戦略の確立を加速させるものである。さらに本研究を介した国内外の共同研究体制の推進は、腎臓における本研究領域の国際的活性化の一助となることが見込まれる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (73 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (4 results) Journal Article (21 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 20 results,  Open Access: 18 results) Presentation (44 results) (of which Int'l Joint Research: 20 results,  Invited: 27 results) Book (1 results) Remarks (3 results)

  • [Int'l Joint Research] University of Miami/L. Miller School of Medicine(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Virginia/Division of Nephrology(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University Lille/Institut Pasteur de Lille(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Miami/L. Miller School of Medicine(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Organelle stress and glycation in kidney disease2021

    • Author(s)
      Inagi Reiko
    • Journal Title

      Glycoconjugate Journal

      Volume: - Issue: 3 Pages: 341-346

    • DOI

      10.1007/s10719-021-09989-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice2020

    • Author(s)
      Mai Sugahara、Shinji Tanaka、Tetsuhiro Tanaka、Hisako Saito、Yu Ishimoto、Takeshi Wakashima、Masatoshi Ueda、Kenji Fukui、Akira Shimizu、Reiko Inagi、Toshimasa Yamauchi、Takashi Kadowaki、Masaomi Nangaku
    • Journal Title

      Journal of the American Society of Nephrology

      Volume: 31 Issue: 3 Pages: 560-577

    • DOI

      10.1681/asn.2019060582

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration2020

    • Author(s)
      Uni Rie、Inoue Tsuyoshi、Nakamura Yasuna、Fukaya Daichi、Hasegawa Sho、Wu Chia-Hsien、Fujii Rie、Surattichaiyakul Bongkod、Peerapanyasut Wachirasek、Ozeki Atsuko、Akimitsu Nobuyoshi、Wada Youichiro、Nangaku Masaomi、Inagi Reiko
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 9472-9472

    • DOI

      10.1038/s41598-020-66295-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Uremic Sarcopenia: Clinical Evidence and Basic Experimental Approach2020

    • Author(s)
      Nishi Hiroshi、Takemura Koji、Higashihara Takaaki、Inagi Reiko
    • Journal Title

      Nutrients

      Volume: 12 Issue: 6 Pages: 1814-1814

    • DOI

      10.3390/nu12061814

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intracellular calcium response of primary cilia of tubular cells to modulated shear stress under oxidative stress2020

    • Author(s)
      Chikamori Masatomo、Kimura Hiroshi、Inagi Reiko、Zhou Jing、Nangaku Masaomi、Fujii Teruo
    • Journal Title

      Biomicrofluidics

      Volume: 14 Issue: 4 Pages: 044102-044102

    • DOI

      10.1063/5.0010737

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Implication of Organelle Cross Talk in AKI2020

    • Author(s)
      Inagi Reiko
    • Journal Title

      Nephron

      Volume: 144 Issue: 12 Pages: 634-637

    • DOI

      10.1159/000508639

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial Dysfunction in Kidney Disease and Uremic Sarcopenia2020

    • Author(s)
      Takemura Koji、Nishi Hiroshi、Inagi Reiko
    • Journal Title

      Frontiers in Physiology

      Volume: 11 Pages: 565023-565023

    • DOI

      10.3389/fphys.2020.565023

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis2019

    • Author(s)
      Jao Tzu-Ming、Nangaku Masaomi、Wu Chia-Hsien、Sugahara Mai、Saito Hisako、Maekawa Hiroshi、Ishimoto Yu、Aoe Mari、Inoue Tsuyoshi、Tanaka Tetsuhiro、Staels Bart、Mori Kazutoshi、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 95 Issue: 3 Pages: 577-589

    • DOI

      10.1016/j.kint.2018.09.023

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/ reperfusion injury in the kidney.2019

    • Author(s)
      Inoue T,Abe C, Kohro T, Tanaka S, Huang L, Yao J, Zheng S, Ye H, Inagi R, Stornetta RL, Rosin DL, Nangaku M, Wada Y, Okusa MD
    • Journal Title

      Kidney International

      Volume: 95(3) Issue: 3 Pages: 563-576

    • DOI

      10.1016/j.kint.2018.09.020

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Organelle crosstalk in the kidney2019

    • Author(s)
      Inoue Tsuyoshi、Maekawa Hiroshi、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 印刷中 Issue: 6 Pages: 1318-1325

    • DOI

      10.1016/j.kint.2018.11.035

    • NAID

      40022012955

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.2019

    • Author(s)
      Mitrofanova A, Mallela SK, Ducasa GM, Yoo TH, Rosenfeld-Gur E, Zelnik ID, Molina J, Varona Santos J, Ge M, Sloan A, Kim JJ, Pedigo C, Bryn J, Volosenco I, Faul C, Zeidan YH, Garcia Hernandez C, Mendez AJ, Leibiger I, Burke GW, Futerman AH, Barisoni L, Ishimoto Y, Inagi R, Merscher S, Fornoni A.
    • Journal Title

      Nat Commun.

      Volume: 10 Issue: 1 Pages: 2692-2692

    • DOI

      10.1038/s41467-019-10584-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes.2019

    • Author(s)
      Ducasa GM, Mitrofanova A, Mallela SK, Liu X, Molina J, Sloan A, Pedigo CE, Ge M, Santos JV, Hernandez Y, Kim JJ, Maugeais C, Mendez AJ, Nair V, Kretzler M, Burke GW, Nelson RG, Ishimoto Y, Inagi R, Banerjee S, Liu S, Szeto HH, Merscher S, Fontanesi F, Fornoni A.
    • Journal Title

      J Clin Invest.

      Volume: 129 Issue: 8 Pages: 3387-3400

    • DOI

      10.1172/jci125316

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lipotoxicity in kidney, heart, and skeletal muscle dysfunction2019

    • Author(s)
      Hiroshi Nishi, Takaaki Higashihara, Reiko Inagi
    • Journal Title

      Nutrients

      Volume: 11 Issue: 7 Pages: 1664-1664

    • DOI

      10.3390/nu11071664

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuroimmune interactions and kidney disease.2019

    • Author(s)
      Hasegawa S, Inoue T, Inagi R.
    • Journal Title

      Kidney Res Clin Pract.

      Volume: 38 Issue: 3 Pages: 282-294

    • DOI

      10.23876/j.krcp.19.014

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury2019

    • Author(s)
      Hiroshi Maekawa, Tsuyoshi Inoue, haruki Ouchi, Tzu-Ming Jao, Reiko Inoue, Hiroshi Nishi, Rie Fujii, Fumiyoshi Ishidate, Tetsuhiro Tanaka, Yosuke Tanaka, Nobutaka Hirokawa, Masaomi Nangaku, Reiko Inagi
    • Journal Title

      Cell Reports

      Volume: 29 Issue: 5 Pages: 1261-1273

    • DOI

      10.1016/j.celrep.2019.09.050

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pathophysiological Role of Organelle Stress/Crosstalk in AKI-to-CKD Transition.2019

    • Author(s)
      Maekawa H, Inagi R.
    • Journal Title

      Semin Nephrol.

      Volume: 39 Issue: 6 Pages: 581-588

    • DOI

      10.1016/j.semnephrol.2019.10.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response2018

    • Author(s)
      Anusornvongchai Thitinun、Nangaku Masaomi、Jao Tzu-Ming、Wu Chia-Hsien、Ishimoto Yu、Maekawa Hiroshi、Tanaka Tetsuhiro、Shimizu Akira、Yamamoto Masayuki、Suzuki Norio、Sassa Ryoji、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 94 Issue: 3 Pages: 536-550

    • DOI

      10.1016/j.kint.2018.03.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sodium glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice2018

    • Author(s)
      Tanaka Shinji、Sugiura Yuki、Saito Hisako、Sugahara Mai、Higashijima Yoshiki、Yamaguchi Junna、Inagi Reiko、Suematsu Makoto、Nangaku Masaomi、Tanaka Tetsuhiro
    • Journal Title

      Kidney International

      Volume: 94 Issue: 5 Pages: 912-925

    • DOI

      10.1016/j.kint.2018.04.025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological and pathophysiological role of reactive oxygen species and reactive nitrogen species in the kidney2018

    • Author(s)
      Ishimoto Yu、Tanaka Tetsuhiro、Yoshida Yoko、Inagi Reiko
    • Journal Title

      Clinical and Experimental Pharmacology and Physiology

      Volume: 45 Issue: 11 Pages: 1097-1105

    • DOI

      10.1111/1440-1681.13018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A simple and effective preparation of quercetin pentamethyl ether from quercetin2018

    • Author(s)
      Tatsuzaki Jin、Ohwada Tomohiko、Otani Yuko、Inagi Reiko、Ishikawa Tsutomu
    • Journal Title

      Beilstein Journal of Organic Chemistry

      Volume: 14 Pages: 3112-3121

    • DOI

      10.3762/bjoc.14.291

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lipotoxicity(脂肪毒性)2018

    • Author(s)
      藤井理恵、井上剛、稲城玲子
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 8 Pages: 370-378

    • NAID

      40021706180

    • Related Report
      2018 Annual Research Report
  • [Presentation] Insights from genetic analysis of tubular biology2021

    • Author(s)
      Reiko Inagi
    • Organizer
      World Congress of Nephrology 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] What we learn from metabolome in the kidney2020

    • Author(s)
      Reiko Inagi
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Role of tubules in interstitial fibrosis2020

    • Author(s)
      Reiko Inagi
    • Organizer
      18th Asian Pacific Congress of Nephrology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organelle Cross-Talk and Tubular Inflammation2020

    • Author(s)
      Reiko Inagi
    • Organizer
      Kidney Week 2020 (American Society of Nephrology)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 腎臓の代謝制御機構から新たな腎臓病治療戦略を探る2020

    • Author(s)
      稲城玲子
    • Organizer
      第57回日本臨床分子医学学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Tubular inflammation via cGAS-STING pathway is a therapeutic target for Acute Kidney Injury2020

    • Author(s)
      Hiroshi Maekawa, Masaomi Nangaku, Reiko Inagi
    • Organizer
      第63回日本腎臓学会学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] シスプラチン誘発性急性腎障害においてミトコンドリアDNA漏出はcGAG-STINGシグナル伝達を介して炎症を引き起こす2020

    • Author(s)
      前川洋、稲城玲子、その他
    • Organizer
      第63回日本腎臓学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 障害後であっても迷走神経刺激は腎保護効果を有する2020

    • Author(s)
      宇仁理恵、稲城玲子、その他
    • Organizer
      第63回日本腎臓学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マクロファージの交感神経シグナル活性化は全身の炎症応答・急性腎障害を軽減する2020

    • Author(s)
      長谷川頌、稲城玲子、その他
    • Organizer
      第63回日本腎臓学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Organelle crosstalk in AKI2020

    • Author(s)
      Reiko Inagi
    • Organizer
      AKI & CRRT 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of tubules in interstitial fibrosis2020

    • Author(s)
      Reiko Inagi
    • Organizer
      Asian Pacific Congress of Nephrology 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] What we learn from metabolome in the kidney2020

    • Author(s)
      稲城玲子
    • Organizer
      第63回日本糖尿病学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Organelle crosstalk and tubular inflammation2020

    • Author(s)
      Reiko Inagi
    • Organizer
      Kedney week 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organelle stress, organelle crosstalk, and kidney disease2019

    • Author(s)
      Reiko Inagi
    • Organizer
      19th TMIMS International Symposium
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mitochondrial disturbance in DKD and other kidney disease2019

    • Author(s)
      Reiko Inagi
    • Organizer
      World Congress of Nephrology 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] グリケーションと加齢・ 代謝性疾患の深いつながり2019

    • Author(s)
      稲城玲子
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 腎臓病の細胞・オルガネラ連関を深掘りする2019

    • Author(s)
      稲城玲子
    • Organizer
      日本抗加齢医学会ーCCVAAシンポジウム2
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 腎臓病と細胞・オルガネラ連関2019

    • Author(s)
      稲城玲子
    • Organizer
      金沢大学先魁2018セミナー:腎臓内科・生化学 合同セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Mitochondrial DNA Leakage Causes Inflammation via the cGAS-STING Axis in Cisplatin-Mediated Tubular Damage2019

    • Author(s)
      Maekawa H et al.
    • Organizer
      Keystone Symposia: Unraveling the secrets of kidney disease in Whistler
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腎臓年齢と酸化ストレスの深い関係2018

    • Author(s)
      稲城玲子
    • Organizer
      第18回日本抗加齢医学総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The role of organelle crosstalk in kidney disease2018

    • Author(s)
      Reiko Inagi
    • Organizer
      Lecture at the Alfred Hospital, Melbourne
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The role of organelle crosstalk in kidney disease2018

    • Author(s)
      Reiko Inagi
    • Organizer
      Biomedical Discovery Seminar in Monash University, Australia
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] オルガネラストレスから腎性貧血とCKDを紐解く2018

    • Author(s)
      稲城玲子
    • Organizer
      第8回 東北女性腎臓医の会 (TSWN)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The Role of Organelle Stress Network in Hypoxia2018

    • Author(s)
      Reiko Inagi
    • Organizer
      Hypoxia Research Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Oxidative/glycative stress, a culprit of organelle stress2018

    • Author(s)
      Reiko Inagi
    • Organizer
      13th International Symposium on the Maillard Reaction
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organelle Crosstalk and Kidney Disease2018

    • Author(s)
      Reiko Inagi
    • Organizer
      Nephrology Round in McGill University, Canada
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 尿細管細胞における cilia-mitochondria クロストーク2018

    • Author(s)
      稲城玲子
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Organelle Crosstalk and Kidney Disease2018

    • Author(s)
      Reiko Inagi
    • Organizer
      Nephrology Round in National Taiwan University
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Organelle Crosstalk and Kidney fibrosis2018

    • Author(s)
      Reiko Inagi
    • Organizer
      The 90th anniversary celebration of National Taiwan University
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 糖化生物学の病態生理 ~食品化学から創薬まで ~2018

    • Author(s)
      稲城玲子
    • Organizer
      第41回日本分子生物学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 慢性疾患治療と食事の役割2018

    • Author(s)
      稲城玲子
    • Organizer
      第2回 D2Kサイエンティスト緊急養成研究集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] D-serine induces senescence via GCN2 activation and amino acid metabolic alterration in human renal tubular cells2018

    • Author(s)
      Okada A et al.
    • Organizer
      The 16th Asian pacific Congress of Nephrology and 2018 Annual Congress of Chinese Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ATF6-mediates lipotoxicity drives tubulointerstitial fibrosis in mice with ischemia-reperfusion injury2018

    • Author(s)
      Jao TM et al.
    • Organizer
      The 16th Asian pacific Congress of Nephrology and 2018 Annual Congress of Chinese Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of Mitochondria in the kidney of autosomal dominant polycystic kidney disease patients2018

    • Author(s)
      Ishimoto Y et al.
    • Organizer
      The 16th Asian pacific Congress of Nephrology and 2018 Annual Congress of Chinese Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mitochondrial DNA Leakage Causes Inflammation via the cGAS-STING Axis in Cisplatin-Mediated Tubular Damage2018

    • Author(s)
      Maekawa H et al.
    • Organizer
      Kidney Week 2018 in San Diego
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ABCA1 Mediated Mitochondrial Dysfunction Contributes to Podocyte Injury in Diabetic Kidney Disease2018

    • Author(s)
      Ducasa GM et al.
    • Organizer
      Kidney Week 2018 in San Diego
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SMPDL3b Modulates Insulin Signaling in Lipid Raft Domains and Interferes with Diabetic Kidney Disease2018

    • Author(s)
      Yoo H
    • Organizer
      Kidney Week 2018 in San Diego
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mitochondrial Morphological Abnormality in Cyst Epithelial Cells of Autosomal Dominant Polycystic Kidney Disease Patients2018

    • Author(s)
      Ishimoto Y et al.
    • Organizer
      Kidney Week 2018 in San Diego
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ATF6α and PPARα Cross-Talk Provides New Insights into Lipotoxicity-Induced Tubulointerstitial Fibrosis2018

    • Author(s)
      Jao TM et al.
    • Organizer
      Kidney Week 2018 in San Diego
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 尿細管酸化ストレス障害によるミトコンドリアDNA漏出はcGAS-STING経路を介した炎症反応を惹起する2018

    • Author(s)
      前川 洋、他
    • Organizer
      第2回日本Uremic Toxin研究会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ATF6 and PPARa crosstalk provides a new insight in lipotoxicity-induced tubulointerstitial fibrosis2018

    • Author(s)
      Jao TM et al.
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Podocyte障害におけるactin重合および細胞弾性の重要性2018

    • Author(s)
      石本 遊、他
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] スフィンゴシンキナーゼ2の下流遺伝子Bst1は、腎虚血再灌流障害および腎臓線維化の進展に重要である2018

    • Author(s)
      井上 剛、他
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] シスプラチンによるミトコンドリアDNA漏出は近位尿細管においてcGAS-STING経路を介した炎症反応を惹起する2018

    • Author(s)
      前川 洋、他
    • Organizer
      第9回分子腎臓フォーラム
    • Related Report
      2018 Annual Research Report
  • [Book] グリケーションの制御とメイラード反応の利用2020

    • Author(s)
      稲城玲子
    • Total Pages
      379
    • Publisher
      シーエムシー出版
    • Related Report
      2020 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科CKD病態生理学講座

    • URL

      http://www.todai-ckd.com

    • Related Report
      2020 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科CKD病態生理学

    • URL

      http://www.todai-ckd.com/

    • Related Report
      2019 Annual Research Report
  • [Remarks]

    • URL

      http://www.todai-ckd.com

    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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