Establishment of biological marker and pathophysiological study of depression using omics analysis
| Project/Area Number |
18H02751
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OHMORI Tetsuro 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (00221135)
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| Co-Investigator(Kenkyū-buntansha) |
沼田 周助 徳島大学, 大学院医歯薬学研究部(医学域), 准教授 (10403726)
渡部 真也 徳島大学, 大学院医歯薬学研究部(医学域), 助教 (90563825)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 臨床精神分子遺伝学 / オミックス解析 / うつ病 / 診断マーカー |
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| Outline of Final Research Achievements |
We attempted to make diagnostic markers for depression by introducing omics analysis technology, and also investigated a customized and simple measurement method. We established an enzymatic method for the practical measurement of glutamate, a candidate marker. The specificity of glutamate alone was low, and no significant association with therapeutic response was observed. We attempted to develop a method to measure candidate marker sites by methylation modification changes using Loop-Mediated Isothermal Amplification (LAMP), but it proved difficult to detect small differences between depressed and healthy subjects. In bipolar disorder, it was found that the methylation differences compared with the normal group were small, the differences were not similar to those of depression, and certain gene groups were affected by mood stabilizers.
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| Academic Significance and Societal Importance of the Research Achievements |
先端的オミックス解析を使用して複数の指標を抽出し、それをうつ病の診断補助マーカーとする国際的にみても先駆的な試みであり、学術的意義は高い。これまでの生物学的指標はひとつの測定値に依拠していたため、感度と特異性に限界があり、実用レベルには至っていない。本研究は、先端的測定技術を用いて、複数の指標を検討して、それらを組み合わせることによって、うつ病の診断評価を高い精度で可能とする道を開いた。技術的進歩によって解析は安価で迅速となり、しかも被験者負担が数mlの採血のみなので患者の同意を得やすく、どこの診察室でも施行可能な検査となる可能性を持っている。
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition and Implication of CDH23 in Schizophrenia2021
Author(s)
Balan S, Ohnishi T, Watanabe A, Ohba H, Iwayama Y, Toyoshima M, Hara T, Hisano Y, Miyasaka Y, Toyota T, Shimamoto-Mitsuyama C, Maekawa M, Numata S, Ohmori T, Shimogori T, Kikkawa Y, Hayashi T, Yoshikawa T
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Journal Title
Schizophr Bull
Volume: -
Issue: 4
Pages: 1190-1200
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Negative and positive self-thought predict subjective QOL in people with schizophrenia2019
Author(s)
Takeda T, Nakataki M, Ohta M, Hamatani S, Matsuura K, Yoshida R, Kameoka N, Tominaga T, Umehara H, Kinoshita M, Watanabe S, Numata S, Sumitani S, Ohmori T.
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Journal Title
Neuropsychiatric Disease and Treatment
Volume: 15
Pages: 293-301
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between social and cognitive functions in people with schizophrenia.2018
Author(s)
Tominaga T, Tomotake M, Takeda T, Ueoka Y, Tanaka T, Watanabe SY, Kameoka N, Nakataki M, Numata S, Izaki Y, Sumitani S, Kubo H, Kaneda Y, Ohmori T.
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Journal Title
Neuropsychiatr Dis Treat.
Volume: 14
Pages: 2215-2224
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Causal relationship between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia.2019
Author(s)
Masashi Ohta, Masahito Nakataki, Tomoya Takeda, Shusuke Numata, Takeo Tominaga, Naomi Kameoka, Hiroko Kubo, Makoto Kinoshita, Kanae Matsuura, Maki Ohtomo, Naoya Takeichi, Masafumi Harada, Tetsuro Ohmori.
Organizer
6th Congress of AsCNP
Related Report
Int'l Joint Research
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