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Molecular imaging study investigating mechanism and pathophysiology of early stage dementia.

Research Project

Project/Area Number 18H02763
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionUniversity of Fukui

Principal Investigator

OKazawa Hidehiko  福井大学, 高エネルギー医学研究センター, 教授 (50360813)

Co-Investigator(Kenkyū-buntansha) 牧野 顕  福井大学, 高エネルギー医学研究センター, 准教授 (00566226)
辻川 哲也  福井大学, 高エネルギー医学研究センター, 准教授 (30380033)
森 哲也  福井大学, 高エネルギー医学研究センター, 助教 (40397287)
井川 正道  福井大学, 学術研究院医学系部門, 講師 (60444212)
米田 誠  福井県立大学, 看護福祉学部, 教授 (70270551)
小坂 浩隆  福井大学, 学術研究院医学系部門, 教授 (70401966)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2020: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords分子イメージング / 認知症 / PET/MRI / 酸化ストレス / 変性タンパク / 機能的MRI / 拡散強調画像 / 拡散テンソル
Outline of Final Research Achievements

In this study, we investigated the pathogenesis and developmental mechanisms of neurodegeneration in detail using PET molecular imaging by analyzing the correlation between the accumulation of amyloid and other dementia lesion proteins and environmental changes in the brain such as oxidative stress. Using the latest PET/MRI technology, we aimed to develop an early diagnosis method by combining various MRI and PET images. Elderly healthy subjects and patients with MCI to early dementia were enrolled in the study. In addition to amyloid and oxidative stress images, resting state fMRI and diffusion images were collected and analyzed, and changes in brain function and structural indices were evaluated along with pathological and physiological changes. The results of this study were reported in numerous English-language papers in Eur J Radiol, EJNMMI Res, Diagnostics and others.

Academic Significance and Societal Importance of the Research Achievements

高齢化社会において認知症診療は最重要課題の一つである。近年アミロイド・タウイメージングの普及により、早期認知症診断、特にアルツハイマー型認知症の診断精度が向上したが、脳の虚血性変化や酸化ストレスも認知症の発症と深く関わっている。本研究で変性タンパクの凝集・蓄積(病変蛋白質)や酸化ストレスなど、脳内環境変化と、認知症に至る神経変性の発生機序との関わりを、臨床データとPET分子イメージングおよび脳MRI画像で詳細に検討を行った意義は大きい。本研究で得られた成果は、今後認知症、神経変性疾患の治療薬開発に役立つと期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (66 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (6 results) Journal Article (25 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 23 results,  Open Access: 19 results) Presentation (32 results) (of which Int'l Joint Research: 12 results,  Invited: 24 results) Book (1 results) Funded Workshop (2 results)

  • [Int'l Joint Research] Stanbford University(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] McGill University(カナダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Southern Denmark(デンマーク)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] McGill University(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Southern Denmark(デンマーク)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of California Davis(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Quantitative Evaluation of 18F-Flutemetamol PET in Patients With Cognitive Impairment and Suspected Alzheimer's Disease: A Multicenter Study2021

    • Author(s)
      Matsuda H, Ito K , Ishii K, Shimosegawa E, Okazawa H, Mishina M, Mizumura S, Ishii K, Okita K, Shigemoto Y, Kato T, Takenaka A, Kaida H, Hanaoka K, Matsunaga K, Hatazawa J, Ikawa M, Tsujikawa T, Morooka M, Ishibashi K, Kameyama M, Yamao T, Miwa K, Ogawa M, Sato N.
    • Journal Title

      Frontiers in Neurology

      Volume: 11 Pages: 578753-578753

    • DOI

      10.3389/fneur.2020.578753

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular imaging for mitochondrial metabolism and oxidative stress in mitochondrial diseases and neurodegenerative disorders2021

    • Author(s)
      Ikawa Masamichi、Okazawa Hidehiko、Yoneda Makoto
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1865 Issue: 3 Pages: 129832-129832

    • DOI

      10.1016/j.bbagen.2020.129832

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease.2020

    • Author(s)
      Okazawa H, Ikawa M, Jung M, Maruyama R, Tsujikawa T, Mori T, Rahman MGM, Makino A, Kiyono Y, Kosaka H
    • Journal Title

      Eur J Nucl Med Mol Img Res

      Volume: 10 Issue: 1 Pages: 30-30

    • DOI

      10.1186/s13550-020-00619-z

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Attenuated activation of the anterior rostral medial prefrontal cortex on self-relevant social reward processing in individuals with autism spectrum disorder2020

    • Author(s)
      Sumiya Motofumi、Okamoto Yuko、Koike Takahiko、Tanigawa Tsubasa、Okazawa Hidehiko、Kosaka Hirotaka、Sadato Norihiro
    • Journal Title

      NeuroImage: Clinical

      Volume: - Pages: 102249-102249

    • DOI

      10.1016/j.nicl.2020.102249

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visual Body Part Representation in the Lateral Occipitotemporal Cortex in Children/Adolescents and Adults2020

    • Author(s)
      Okamoto Yuko、Kitada Ryo、Kochiyama Takanori、Naruse Hiroaki、Makita Kai、Miyahara Motohide、Okazawa Hidehiko、Kosaka Hirotaka
    • Journal Title

      Cerebral Cortex Communications

      Volume: in press Issue: 1 Pages: 1-13

    • DOI

      10.1093/texcom/tgaa007

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel automatic approach for calculation of the specific binding ratio in [I-123]FP-CIT SPECT.2020

    • Author(s)
      Rahman MGM, Islam MM, Tsujikawa T, Okazawa H
    • Journal Title

      Diagnostics

      Volume: 10 Issue: 5 Pages: 289-289

    • DOI

      10.3390/diagnostics10050289

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI2020

    • Author(s)
      Fan Audrey P.、An Hongyu、Moradi Farshad、Rosenberg Jarrett、Ishii Yosuke、Nariai Tadashi、Okazawa Hidehiko、Zaharchuk Greg
    • Journal Title

      NeuroImage

      Volume: 220 Pages: 117136-117136

    • DOI

      10.1016/j.neuroimage.2020.117136

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PET Imaging for Oxidative Stress in Neurodegenerative Disorders Associated with Mitochondrial Dysfunction2020

    • Author(s)
      Ikawa Masamichi、Okazawa Hidehiko、Nakamoto Yasunari、Yoneda Makoto
    • Journal Title

      Antioxidants

      Volume: 9 Issue: 9 Pages: 861-861

    • DOI

      10.3390/antiox9090861

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intrinsic brain activity associated with eye gaze during mother-child interaction2020

    • Author(s)
      Kuboshita R, Fujisawa TX, Makita K, Kasaba R, Okazawa H, Tomoda A.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 18903-18903

    • DOI

      10.1038/s41598-020-76044-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Noninvasive Measurement of [11C]PiB Distribution Volume Using Integrated PET/MRI2020

    • Author(s)
      Okazawa Hidehiko、Ikawa Masamichi、Tsujikawa Tetsuya、Makino Akira、Mori Tetsuya、Kiyono Yasushi、Kosaka Hirotaka
    • Journal Title

      Diagnostics

      Volume: 10 Issue: 12 Pages: 993-993

    • DOI

      10.3390/diagnostics10120993

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visual body part representation in the lateral occipitotemporal cortex in children/adolescents and adults.2020

    • Author(s)
      Okamoto Y, Kitada R, Kochiyama T, Naruse H, Makita K, Miyahara M, Okazawa H, Kosaka H
    • Journal Title

      Cereb Cortex Commun

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 平成29・30 年度 ワーキンググループ報告2020

    • Author(s)
      岡沢秀彦、伊藤 浩, 渡邊祐司, 野上宗伸, 栗原宏明, 伊藤公輝, 田所匡典, 小林靖宏, 関根鉄朗, 久保均, 吉川健啓, 佐々木道郎
    • Journal Title

      KAKUIGAKU

      Volume: 57 Issue: 1 Pages: 27-29

    • DOI

      10.18893/kakuigaku.wgr.2034

    • NAID

      130007826079

    • ISSN
      2189-9932
    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] 平成29・30 年度 ワーキンググループ報告2020

    • Author(s)
      外山 宏, 乾 好貴, 市原 隆, 宇野正樹, 伊藤健吾, 加藤克彦, 岡沢秀彦, 市川泰崇, 山崎孝浩
    • Journal Title

      KAKUIGAKU

      Volume: 57 Issue: 1 Pages: 23-26

    • DOI

      10.18893/kakuigaku.wgr.2033

    • NAID

      130007826080

    • ISSN
      2189-9932
    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] 総説 酸化ストレスイメージング-ミトコンドリア病,神経変性疾患への応用2019

    • Author(s)
      井川正道、岡沢秀彦、米田誠
    • Journal Title

      BRAIN and NERVE

      Volume: 71 Issue: 2 Pages: 161-166

    • DOI

      10.11477/mf.1416201236

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2019-02-01
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local-to-distant development of the cerebrocerebellar sensorimotor network in the typically developing human brain: a functional and diffusion MRI study2019

    • Author(s)
      Amemiya Kaoru、Morita Tomoyo、Saito Daisuke N.、Ban Midori、Shimada Koji、Okamoto Yuko、Kosaka Hirotaka、Okazawa Hidehiko、Asada Minoru、Naito Eiichi
    • Journal Title

      Brain Structure and Function

      Volume: in press Issue: 3 Pages: 1359-1375

    • DOI

      10.1007/s00429-018-01821-5

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] No significant difference found in PET/MRI CBF values reconstructed with CT-atlas-based and ZTE MR attenuation correction.2019

    • Author(s)
      Okazawa H, Tsujikawa T, Higashino Y, Kikuta K, Mori T, Makino A, Kiyono Y
    • Journal Title

      Eur J Nucl Med Mol Img Res

      Volume: 9 Issue: 1 Pages: 26-26

    • DOI

      10.1186/s13550-019-0494-9

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Do Individuals With Autism Spectrum Disorders Help Other People With Autism Spectrum Disorders? An Investigation of Empathy and Helping Motivation in Adults With Autism Spectrum Disorder2019

    • Author(s)
      Komeda Hidetsugu、Kosaka Hirotaka、Fujioka Toru、Jung Minyoung、Okazawa Hidehiko
    • Journal Title

      Frontiers in Psychiatry

      Volume: 10 Pages: 376-376

    • DOI

      10.3389/fpsyt.2019.00376

    • NAID

      120006777480

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex differences in white matter pathways related to language ability.2019

    • Author(s)
      Jung M, Mody M, Fujioka T, Kimura Y, Okazawa H, Kosaka H
    • Journal Title

      Front Neurosci

      Volume: 13 Pages: 898-898

    • DOI

      10.3389/fnins.2019.00898

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 脳血管障害のPET、SPECT2019

    • Author(s)
      岡沢 秀彦
    • Journal Title

      医学のあゆみ

      Volume: 270 Pages: 714-719

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Count-based method for specific binding ratio calculation in [I-123]FP-CIT SPECT analysis.2019

    • Author(s)
      Rahman MGM, Islam MM, Tsujikawa T, Kiyono Y, Okazawa H
    • Journal Title

      Ann Nucl Med

      Volume: 33 Issue: 1 Pages: 14-21

    • DOI

      10.1007/s12149-018-1297-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Noninvasive method for measurement of cerebral blood flow using O-15 water PET/MRI with ASL correlation.2018

    • Author(s)
      Okazawa H, Higashino Y, Tetsuya Tsujikawa T, Arishima H, Mori T, Kiyono Y, Kimura H, Kikuta K.
    • Journal Title

      Eur J Radiol

      Volume: 105 Pages: 102-109

    • DOI

      10.1016/j.ejrad.2018.05.033

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arterial spin labeling MR imaging for the clinical detection of cerebellar hypoperfusion in patients with spinocerebellar degeneration.2018

    • Author(s)
      Ikawa M, Kimura, H, Kitazaki Y, Sugimoto K, Matsunaga A, Hayashi K, Yamamura O, Tsujikawa T, Hamano T, Yoneda M, Okazawa H, Nakamoto Y.
    • Journal Title

      J Neurol Sci

      Volume: 394 Pages: 58-62

    • DOI

      10.1016/j.jns.2018.09.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered perspective-dependent brain activation while viewing hands and associated imitation difficulties in individuals with autism spectrum disorder.2018

    • Author(s)
      Okamoto Y, Kitada R, Miyahara M, Kochiyama T, Naruse H, Sadato N, Okazawa H, Kosaka H.
    • Journal Title

      NeuroImage: Clinical

      Volume: in press. Pages: 384-395

    • DOI

      10.1016/j.nicl.2018.04.030

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Self-Face Recognition Begins to Share Active Region in Right Inferior Parietal Lobule with Proprioceptive Illusion During Adolescence2018

    • Author(s)
      Morita Tomoyo、Saito Daisuke N、Ban Midori、Shimada Koji、Okamoto Yuko、Kosaka Hirotaka、Okazawa Hidehiko、Asada Minoru、Naito Eiichi
    • Journal Title

      Cerebral Cortex

      Volume: 28 Issue: 4 Pages: 1532-1548

    • DOI

      10.1093/cercor/bhy027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CT-based attenuation correction and resolution compensation for I-123 IMP brain SPECT normal database: a multicenter phantom study.2018

    • Author(s)
      Inui Y, Ichihara T, Uno M, Ishiguro M, Ito K, Kato K, Sakuma H, Okazawa H, Toyama H.
    • Journal Title

      Ann Nucl Med

      Volume: 32 Issue: 5 Pages: 311-318

    • DOI

      10.1007/s12149-018-1248-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Current PET/MRI technique for quantitative evaluation of brain imaging2021

    • Author(s)
      Okazawa H
    • Organizer
      18th Asian Oceanian Congress of Radiology (AOCR 2021)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multimodal evaluation of brain functions in patients with Alzheimer’s disease using PiB-PET/MRI.2020

    • Author(s)
      Okazawa H, Ikawa M, Jung M, Tsujikawa T, Mori T, Makino M, Kiyono Y, Kosaka H
    • Organizer
      67th Annual Meeting of The Society of Nuclear Medicine and Molecular Imaging 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of an automatic calculation method for the specific binding ratio in [I-123]ioflupne SPECT2020

    • Author(s)
      Hidehiko Okazawa, Muhammad M. Islam, Mahmudur G.M. Rahman, Tetsuya Tsujikawa
    • Organizer
      34th Annual Congress of the European Association of Nuclear Medicine
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳血流総論・脳血管障害2020

    • Author(s)
      岡沢秀彦
    • Organizer
      第79回日本医学放射線学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] PET/MRIによる脳ドック検診2020

    • Author(s)
      岡沢秀彦
    • Organizer
      第29 回日本脳ドック学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 脳のアミロイド・タウイメージング2020

    • Author(s)
      岡沢秀彦
    • Organizer
      第56回日本医学放射線学会秋季臨床大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] PET/MRIによる脳機能マルチモダリティ解析2020

    • Author(s)
      岡沢秀彦
    • Organizer
      第11回札幌神経科学研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] PET/MR International Experience and Opportunities -PET/MR in Japan-2020

    • Author(s)
      Okazawa H
    • Organizer
      2020 Annual Meeting of American College of Nuclear Medicine (ACNM)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 認知症・変性疾患における画像診断の有用性と今後の展望「放射線科医の立場から」2020

    • Author(s)
      岡沢秀彦
    • Organizer
      第72回栃木県核医学研修会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 画像による脳の老化と神経変性発症過程の解明2019

    • Author(s)
      岡沢秀彦、伊藤 浩、野上宗伸
    • Organizer
      第62回日本脳循環代謝学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] PET/MRIの標準的撮像法の確立と定量性評価2019

    • Author(s)
      岡沢秀彦
    • Organizer
      第59回日本核医学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 福井から世界へ -分子イメージング最前線-2019

    • Author(s)
      岡沢秀彦、辻川哲也、森 哲也、牧野 顕、清野 泰
    • Organizer
      第118回日本医学物理学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脳神経系の核医学診断:最近の話題2019

    • Author(s)
      岡沢秀彦
    • Organizer
      日本核医学会 第89回中部地方会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Quantitative brain PET/MRI imaging and its clinical application.2019

    • Author(s)
      Okazawa H
    • Organizer
      Brain PET 2019 (The 14th International Conference on Quantification of Brain Function with PET)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Comparison of MR attenuation correction methods using CT-atlas vs. zero-TE on quantitative H215O-PET/MRI2019

    • Author(s)
      Okazawa H, Tsujikawa T, Higashino Y, Mori T, Makino A, Kiyono Y.
    • Organizer
      Brain PET 2019 (The 14th International Conference on Quantification of Brain Function with PET)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of MR attenuation correction using CT-atlas based vs. zero-TE on quantitative 15O-water PET/MRI2019

    • Author(s)
      Okazawa H, Tsujikawa T, Higashino Y, Mori T, Makino M, Kiyono Y.
    • Organizer
      The 66th Annual Meeting of Society of Nuclear Medicine and Molecular Imaging
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Brain PET/MRI for evaluation of neurodegenerative diseases.2019

    • Author(s)
      Okazawa H, Ikawa M, Tsujikawa T, Kosaka H.
    • Organizer
      The 13th Asia Oceania Congress of Nuclear Medicine and Biology.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Preparation and evaluation of biodegradable polymer micelle for brachytherapy.2019

    • Author(s)
      Makino A, Mori T, Okazawa H, Kiyono Y
    • Organizer
      32nd Annual Congress of the European Association of Nuclear Medicine
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of radiobromine-labeled (SS)-BPBM for imaging of the brain norepinephrine transporter.2019

    • Author(s)
      Kiyono Y, Mori T, Asai T, Okazawa H
    • Organizer
      Brain PET 2019 (The 14th International Conference on Quantification of Brain Function with PET)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New Frontiers of Fusion Images in Neuroimaging2018

    • Author(s)
      Okazawa H
    • Organizer
      第76回日本医学放射線学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Count-based method for specific binding ratio calculation in [I-123]FP-CIT SPECT analysis2018

    • Author(s)
      Rahman M, Islam M, Tsujikawa T, Sugimoto K, Okazawa H
    • Organizer
      The 12th World Congress of the World Federation of Nuclear Medicine and Biology (WFNMB 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ハイブリッド型PET/MRIで何が見えるのか -最先端画像の臨床活用法-2018

    • Author(s)
      岡沢秀彦
    • Organizer
      第97回福井県医学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] A new method for [123I]FP-CIT specific binding ratio estimation in evaluation of striatal function.2018

    • Author(s)
      Rahman M, Islam M, Tsujikawa T, Kiyono Y, Okazawa H
    • Organizer
      The 65th Annual Meeting of The Society of Nuclear Medicine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 最新型ハイブリッドPET/MRI画像の基礎と臨床応用2018

    • Author(s)
      岡沢秀彦
    • Organizer
      第35回日本ハイパーサーミア学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] PETによる生体イメージング2018

    • Author(s)
      岡沢秀彦
    • Organizer
      第27回バイオイメージング学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 画像による脳の老化と神経変性発症過程の解明2018

    • Author(s)
      岡沢秀彦、伊藤浩、野上宗伸
    • Organizer
      第61回日本脳循環代謝学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] PET/MRIで実現する脳機能画像の最前線2018

    • Author(s)
      岡沢秀彦
    • Organizer
      第63回兵庫県核医学研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] PET/MRI検査の基礎と臨床的有用性2018

    • Author(s)
      岡沢秀彦
    • Organizer
      第58回日本核医学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] PET/MRIの標準的撮像法の確立と定量性評価2018

    • Author(s)
      岡沢秀彦
    • Organizer
      第58回日本核医学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] PET/MRIの臨床的有用性:悪性腫瘍と神経変性疾患への応用2018

    • Author(s)
      岡沢秀彦
    • Organizer
      第32回九州PET研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] PET/MRIを用いた脳機能イメージング2018

    • Author(s)
      岡沢秀彦
    • Organizer
      第23回ニューロイメージングカンファレンス
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] PET/MRIで健康チェック2018

    • Author(s)
      岡沢秀彦
    • Organizer
      福井大学ホームカミングデイ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Book] PET/MRIの臨床2020

    • Author(s)
      岡沢秀彦、伊藤浩編(日本核医学会PET/MRIの標準的撮像法の確立と定量性評価ワーキンググループ)
    • Total Pages
      168
    • Publisher
      診断と治療社
    • ISBN
      9784787824691
    • Related Report
      2020 Annual Research Report
  • [Funded Workshop] Progress in Tau Imaging2019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] PET Pharmacokinetics Course 20192019

    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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