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Development of radiation therapy technique based on next imaging modality

Research Project

Project/Area Number 18H02765
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionGifu University

Principal Investigator

Matsuo Masayuki  岐阜大学, 大学院医学系研究科, 教授 (40377669)

Co-Investigator(Kenkyū-buntansha) 兵藤 文紀  岐阜大学, 大学院医学系研究科, 特任准教授 (10380693)
森 崇  岐阜大学, 応用生物科学部, 教授 (40402218)
富田 弘之  岐阜大学, 大学院医学系研究科, 准教授 (50509510)
五島 聡  浜松医科大学, 医学部, 教授 (90402205)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords放射線治療 / レドックス / MRI / 次世代放射線治療 / 分子イメージング / 腫瘍内レドックス代謝 / 分子画像 / 悪性グリオーマ / 酸素 / 画像診断
Outline of Final Research Achievements

Radiotherapy plays a very important role as one of the major treatments for cancer. It is known that the treatment efficacy depends on redox modulation in tumor tissues, which is an indirect effect of oxidizing redox molecules such as hydroxyl radicals and of reactive oxygen species generated by radiation treatment. In vivo dynamic nuclear polarization-MRI (DNP-MRI) as a redox sensitive DNP probe enables the accurate monitoring of the anatomical distribution of free radicals based on interactions of electrons and nuclear spin, known as Overhauser effect. We found that the redox metabolism decreases after radiation treatment, and the decay of redox metabolism occurs before any micro- or macroscopic changes in tumor morphology and lactate metabolism based on the Warburg effect. Our findings suggest that DNP-MRI-based redox imaging may be a potential imaging biomarker for the assessment of early responses to radiotherapy.

Academic Significance and Societal Importance of the Research Achievements

悪性腫瘍に罹患している患者のうち、国内での放射線治療の利用率は現在およそ30%であるが、20年後には50%近くの患者が放射線治療を受ける時代になると推測されている。近年の放射線治療の高精度化に伴い、がん局所に集中的に放射線照射が可能となり、治療効果の向上や有害事象が軽減している。一方、治療の多様化と高精度化が進むにつれて、放射線治療前後の、より精密な解剖学的情報だけに頼らない、新しい画像診断のニーズが高まってきた。放射線治療直後は腫瘍内のレドックス状態は撹乱された状態であるため、レドックス変動の可視化ができれば放射線治療効果向上や早期の治療効果診断が期待できる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (30 results)

All 2021 2020 2018

All Journal Article (23 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 22 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Utility of Noncontrast Magnetic Resonance Angiography for Aneurysm Follow-Up and Detection of Endoleaks after Endovascular Aortic Repair2021

    • Author(s)
      Kawada Hiroshi、Goshima Satoshi、Sakurai Kota、Noda Yoshifumi、Kajita Kimihiro、Tanahashi Yukichi、Kawai Nobuyuki、Ishida Narihiro、Shimabukuro Katsuya、Doi Kiyoshi、Matsuo Masayuki
    • Journal Title

      Korean Journal of Radiology

      Volume: 22 Issue: 4 Pages: 513-513

    • DOI

      10.3348/kjr.2020.0001

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glucose transporter Glut1 controls diffuse invasion phenotype with perineuronal satellitosis in diffuse glioma microenvironment.2020

    • Author(s)
      Miyai M, Kanayama T, Hyodo F, Kinoshita T, Ishihara T, Okada H, Suzuki H, Takashima S, Wu Z, Hatano Y, Egashira Y, Enomoto Y, Nakayama N, Soeda A, Yano H, Hirata A, Niwa M, Sugie S, Mori T, Maekawa Y, Iwama T, Matsuo M, Hara A, Tomita H
    • Journal Title

      Neurooncol Adv.

      Volume: 30 Issue: 1 Pages: 06198-06198

    • DOI

      10.1093/noajnl/vdaa150

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emphysematous cholecystitis during the treatment of heat stroke2020

    • Author(s)
      Yoshiyama Naomasa、Okada Hideshi、Miyake Takahito、Kitagawa Yuichiro、Fukuta Tetsuya、Yasuda Ryu、Matsuo Mikiko、Hatano Yuichiro、Tomita Hiroyuki、Yoshida Shozo、Ogura Shinji
    • Journal Title

      Acute Medicine & Surgery

      Volume: 7 Issue: 1

    • DOI

      10.1002/ams2.613

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vascular events from carotid artery atherosclerosis after radiation therapy for laryngeal and hypopharyngeal cancer: the incidence and risk factors.2020

    • Author(s)
      Makita C, Okada S, Kajiura Y, Tanaka O, Asahi Y, Yamada N, Yanagida M, Kumagai M, Murase S, Ito M, Kumano T, Matsuo M
    • Journal Title

      Nagoya J Med Sci.

      Volume: 82 Pages: 747-761

    • NAID

      120006900378

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A pediatric case of anaplastic astrocytoma with a gliomatosis cerebri; the growth pattern and changes in serum VEGF-121 levels after bevacizumab treatment2020

    • Author(s)
      Ninomiya Hiroshi、Ozeki Michio、Matsuzawa Yoriko、Nozawa Akifumi、Yasue Shiho、Kubota Kazuo、Endo Saori、Asano Takahiko、Taguchi Kohtaro、Ohe Naoyuki、Matsuo Masayuki、Iwama Toru、Ohnishi Hidenori
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 81 Pages: 431-433

    • DOI

      10.1016/j.jocn.2020.10.009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Imaging Findings between Human Papillomavirus-positive and -Negative Squamous Cell Carcinomas of the Maxillary Sinus2020

    • Author(s)
      Kawaguchi Masaya、Kato Hiroki、Tomita Hiroyuki、Hara Akira、Suzui Natsuko、Miyazaki Tatsuhiko、Matsuo Masayuki
    • Journal Title

      Journal of Clinical Imaging Science

      Volume: 10 Pages: 59-59

    • DOI

      10.25259/jcis_116_2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of Hydroxyl-Radical Generation Using Dynamic Nuclear Polarization-Magnetic Resonance Imaging and a Spin-Trapping Agent2020

    • Author(s)
      Shoda Shinichi、Hyodo Fuminori、Tachibana Yoko、Kiniwa Mamoru、Naganuma Tatsuya、Eto Hinako、Koyasu Norikazu、Murata Masaharu、Matsuo Masayuki
    • Journal Title

      Analytical Chemistry

      Volume: 92 Issue: 21 Pages: 14408-14414

    • DOI

      10.1021/acs.analchem.0c02331

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel molecular probe for the detection of liver mitochondrial redox metabolism2020

    • Author(s)
      Hosain Md. Zahangir、Hyodo Fuminori、Mori Takeshi、Takahashi Koyo、Nagao Yusuke、Eto Hinako、Murata Masaharu、Akahoshi Tomohiko、Matsuo Masayuki、Katayama Yoshiki
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 16489-16489

    • DOI

      10.1038/s41598-020-73336-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MR imaging findings for differentiating cutaneous malignant melanoma from squamous cell carcinoma.2020

    • Author(s)
      Kawaguchi M, Kato H, Tomita H, Hara A, Suzui N, Miyazaki T, Matsuyama K, Seishima M, Matsuo M
    • Journal Title

      Eur J Radiol.

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intranodal Popliteal Lymphangiography for Postoperative Lymphorrhea after Inguinal Node Dissection2020

    • Author(s)
      Tanahashi Yukichi、Kawada Hiroshi、Goshima Satoshi、Takahashi Takao、Yoshida Kazuhiro、Matsuo Masayuki
    • Journal Title

      Journal of Vascular and Interventional Radiology

      Volume: 31 Issue: 11 Pages: 1926-1929

    • DOI

      10.1016/j.jvir.2020.03.018

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperdense Thymic Atrophy After Chemotherapy in Pediatric Patients With Extrathoracic Malignancies2020

    • Author(s)
      Kawaguchi Masaya、Kato Hiroki、Kaneko Yo、Matsuo Masayuki
    • Journal Title

      Journal of Computer Assisted Tomography

      Volume: 44 Issue: 6 Pages: 865-869

    • DOI

      10.1097/rct.0000000000001101

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiotherapy for prostate cancer: Effect of gold fiducial markers on diffusion‐weighted magnetic resonance imaging2020

    • Author(s)
      Tanaka Osamu、Maejima Ryoshu、Yama Eiichi、Taniguchi Takuya、Ono Kousei、Makita Chiyoko、Matsuo Masayuki
    • Journal Title

      Asia-Pacific Journal of Clinical Oncology

      Volume: 17 Issue: 1 Pages: 79-83

    • DOI

      10.1111/ajco.13409

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Can MRI features differentiate ovarian mucinous carcinoma from mucinous borderline tumor?2020

    • Author(s)
      Kaga Tetsuro、Kato Hiroki、Hatano Yuichiro、Kawaguchi Masaya、Furui Tatsuro、Morishige Ken-ichirou、Matsuo Masayuki
    • Journal Title

      European Journal of Radiology

      Volume: 132 Pages: 109281-109281

    • DOI

      10.1016/j.ejrad.2020.109281

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MR imaging findings for differentiating nonhemophilic hemosiderotic synovitis from diffuse-type tenosynovial giant cell tumor of the knee2020

    • Author(s)
      Ando Tomohiro、Kato Hiroki、Kawaguchi Masaya、Nagano Akihito、Hyodo Fuminori、Matsuo Masayuki
    • Journal Title

      Japanese Journal of Radiology

      Volume: 39 Issue: 1 Pages: 76-83

    • DOI

      10.1007/s11604-020-01034-z

    • NAID

      210000182902

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic contrast-enhanced computed tomography lymphangiography with intranodal injection of water-soluble iodine contrast media in microminipig: imaging protocol and feasibility2020

    • Author(s)
      Tanahashi Yukichi、Iwasaki Ryota、Shoda Shinichi、Kawada Hiroshi、Ando Tomohiro、Takasu Masaki、Hyodo Fuminori、Goshima Satoshi、Mori Takashi、Matsuo Masayuki
    • Journal Title

      European Radiology

      Volume: 30 Issue: 11 Pages: 5913-5922

    • DOI

      10.1007/s00330-020-07031-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic resonance imaging findings of extrauterine high-grade serous carcinoma based on new pathologic criteria for primary site assignment2020

    • Author(s)
      Kawaguchi Masaya、Kato Hiroki、Hatano Yuichiro、Tomita Hiroyuki、Hara Akira、Miyazaki Tatsuhiko、Matsuo Masayuki
    • Journal Title

      Acta Radiologica

      Volume: 62 Issue: 5 Pages: 687-694

    • DOI

      10.1177/0284185120934474

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypointense head and neck lesions on T2-weighted images: correlation with histopathologic findings2020

    • Author(s)
      Kato Hiroki、Kawaguchi Masaya、Ando Tomohiro、Kaneko Yo、Hyodo Fuminori、Matsuo Masayuki
    • Journal Title

      Neuroradiology

      Volume: 62 Issue: 10 Pages: 1207-1217

    • DOI

      10.1007/s00234-020-02483-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictive factors of rectal hemorrhage in patients with localized prostate cancer who underwent low-dose-rate brachytherapy2020

    • Author(s)
      Taniguchi Tomoki、Iinuma Koji、Kato Daiki、Takai Manabu、Maekawa Yuka Muramatsu、Nakane Keita、Mizutani Kosuke、Tsuchiya Tomohiro、Nakano Masahiro、Kato Taku、Ito Masaya、Kumano Tomoyasu、Matsuo Masayuki、Koie Takuya
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 25 Issue: 9 Pages: 1711-1717

    • DOI

      10.1007/s10147-020-01713-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation therapy combined with bone-modifying agents ameliorates local control of osteolytic bone metastases in breast cancer2020

    • Author(s)
      Tanaka Hidekazu、Makita Chiyoko、Manabe Yuki、Kajima Miki、Matsuyama Katsuya、Matsuo Masayuki
    • Journal Title

      Journal of Radiation Research

      Volume: 61 Issue: 3 Pages: 494-498

    • DOI

      10.1093/jrr/rraa020

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Detection of pancreatic ductal adenocarcinoma and liver metastases: comparison of Gd-EOB-DTPA-enhanced MR imaging vs. extracellular contrast materials2020

    • Author(s)
      Noda Yoshifumi、Goshima Satoshi、Takai Yukiko、Kawai Nobuyuki、Kawada Hiroshi、Tanahashi Yukichi、Matsuo Masayuki
    • Journal Title

      Abdominal Radiology

      Volume: 45 Issue: 8 Pages: 2459-2468

    • DOI

      10.1007/s00261-020-02511-9

    • NAID

      120007026255

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MR imaging findings of low-grade serous carcinoma of the ovary: comparison with serous borderline tumor2020

    • Author(s)
      Kawaguchi Masaya、Kato Hiroki、Hatano Yuichiro、Tomita Hiroyuki、Hara Akira、Suzui Natsuko、Miyazaki Tatsuhiko、Furui Tatsuro、Morishige Ken-ichirou、Matsuo Masayuki
    • Journal Title

      Japanese Journal of Radiology

      Volume: 38 Issue: 8 Pages: 782-789

    • DOI

      10.1007/s11604-020-00960-2

    • NAID

      50014569067

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Co-imaging of the tumor oxygenation and metabolism using electron paramagnetic resonance imaging and 13-C hyperpolarized magnetic resonance imaging before and after irradiation2018

    • Author(s)
      Matsuo Masayuki、Kawai Tatsuya、Kishimoto Shun、Saito Keita、Munasinghe Jeeva、Devasahayam Nallathamby、Mitchell James B.、Krishna Murali C.
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 38 Pages: 25089-25100

    • DOI

      10.18632/oncotarget.25317

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoinduced in Vivo Magnetic Resonance Imaging (MRI) with Rapid CO Release from an MnCO-Protein Needle Composite2018

    • Author(s)
      Hyodo Fuminori、Sho Takeya、Maity Basudev、Fujita Kenta、Tachibana Yoko、Akashi Satoko、Mano Megumi、Hishikawa Yuki、Matsuo Masayuki、Ueno Takafumi
    • Journal Title

      Chemistry - A European Journal

      Volume: 24 Issue: 45 Pages: 11578-11583

    • DOI

      10.1002/chem.201802445

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 岐阜大学における医学と獣医学の橋渡し研究2021

    • Author(s)
      松尾政之
    • Organizer
      シンポジウム「ホウ素中性子捕捉療法(BNCT)の獣医学分野への適応拡大に向けて-取り組むべき課題と異分野融合研究の可能性-」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 放射線治療における再酸素化とエネルギー代謝2020

    • Author(s)
      松尾政之
    • Organizer
      第22回癌治療増感研究シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 分子画像の放射線治療への応用2020

    • Author(s)
      松尾政之
    • Organizer
      第40回日本脳神経外科コングレス総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 酸素化におけるCycling Hypoxiaの画像化2020

    • Author(s)
      松尾政之
    • Organizer
      日本放射線腫瘍学会第33回学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Estimation of Re-appearance of cycling hypoxia after irradiation2018

    • Author(s)
      M. Matsuo, 兵藤文紀, 田中秀和, 山口尊弘, 江﨑可絵, J.B.Mitchell, M. Krishma
    • Organizer
      日本放射線腫瘍学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Estimation of Re-appearance of cycling hypoxia after irradiation2018

    • Author(s)
      M. Matsuo, F. Hyodo, H. Tanaka, T. Yamaguchi, M. Krishma, J.B.Mitchell
    • Organizer
      ASTRO
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Book] Medical Science Digest 2020年 11月臨時増刊号2020

    • Author(s)
      笹井 啓資(順天堂大学放射線治療学講座)
    • Total Pages
      64
    • Publisher
      ニュー・サイエンス社
    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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