Visualization and quantification of microstructures of the brain: new concept using next-generation advanced diffusion MR imaging
Project/Area Number |
18H02772
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 52040:Radiological sciences-related
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Research Institution | Juntendo University |
Principal Investigator |
青木 茂樹 順天堂大学, 大学院医学研究科, 教授 (80222470)
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Co-Investigator(Kenkyū-buntansha) |
下地 啓五 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20348931)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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Keywords | 拡散MRI / 拡散時間 / 脳 / 制限拡散 / microstructure / 拡散テンソル / 粘稠度 / epidermoid cyst / 定量MRI / 神経疾患 / MRI / 拡散 / 次世代拡散MRI / 微細構造 |
Outline of Annual Research Achievements |
次世代拡散MRIによる脳微細構造の観察と定量として、短い拡散時間のOscillating gradient spin-echo(OGSE)を用い、微細構造変化が観察可能と思われる種々の病変に対して、検討を行った。従来の長い拡散時間の拡散強調像で高信号を呈する疾患で、短い拡散時間の拡散強調像で信号強度や見かけの拡散係数がどのように変化するかを検討した。従来の拡散強調像(長い拡散時間)による計測では、液体の粘稠度のみで拡散係数が短いものと、種々の構造により制限拡散が生じ拡散係数が短くなるものがともに高信号となるが、OGSEによる短い拡散時間では制限拡散によるものの一部(ちょうど拡散時間と微細構造がマッチした時)では、信号低下が起きることが予想され、微細構造が推定できる可能性を検討した。この研究は、実際にMRIの性能向上により、拡散強調像高信号が目立たなくなる疾患があることから発想した。類上皮腫(MRMS2018),急性期脳梗塞(Neurorad2018)、脈絡叢嚢胞(MRI2019), 脳腫瘍(MRI 2020), 脳梁膨大部病変(MRMS 2021),脳膿瘍(MRMS2022)およびファントム(JJR2018)で拡散時間の影響を調べた。これらは臨床における短い拡散時間を用いた微細構造研究として世界に先駆けるものであった。 拡散制限の原因として、類上皮腫の層状構造によるものが信号に影響を与えることが示される一方、急性期脳梗塞や腫瘍などでは現在のOGSE信号の低下は一部であった。制限拡散を起こす微細構造が現在のOGSEで観察できる5-10μmよりも小さいと考えられた。また、通常の撮像法でも拡散時間が短くなってきており、場合によってはコントラストが低下するため、拡散時間を考慮したプロトコールが望まれることも示された。
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Research Progress Status |
令和2年度が最終年度であるため、記入しない。
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Strategy for Future Research Activity |
令和2年度が最終年度であるため、記入しない。
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Report
(3 results)
Research Products
(107 results)
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[Journal Article] Comparison of Brain Volume Measurements Made with 0.3- and 3-T MR Imaging2022
Author(s)
Murata Syo、Hagiwara Akifumi、Kaga Hideyoshi、Someya Yuki、Nemoto Kiyotaka、Goto Masami、Kamagata Koji、Irie Ryusuke、Hori Masaaki、Andica Christina、Wada Akihiko、Kumamaru Kanako Kunishima、Shimoji Keigo、Otsuka Yujiro、Hoshito Haruyoshi、Tamura Yoshifumi、Kawamori Ryuzo、Watada Hirotaka、Aoki Shigeki
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Journal Title
MRMS
Volume: -
Issue: 3
Pages: 517-524
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Deep Learning Approach for Generating MRA Images From 3D Quantitative Synthetic MRI Without Additional Scans2020
Author(s)
Fujita S., Hagiwara A., Otsuka Y., Hori M., Takei N., Hwang K. P., Irie R., Andica C., Kamagata K., Akashi T., Kumamaru K. K., Suzuki M., Wada A., Abe O., Aoki S.
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Journal Title
Investigative Radiology
Volume: 55
Pages: 249-256
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A Novel Deep Learning Approach with a 3D Convolutional Ladder Network for Differential Diagnosis of Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease2020
Author(s)
Irie R., Otsuka Y., Hagiwara A., Kamagata K., Kamiya K., Suzuki M., Wada A., Maekawa T., Fujita S., Kato S., Nakajima M., Miyajima M., Motoi Y., Abe O., Aoki S.
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Journal Title
MRMS
Volume: -
Issue: 4
Pages: 351-358
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access
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[Journal Article] Differentiation of high-grade and low-grade intra-axial brain tumors by time-dependent diffusion MRI2020
Author(s)
Tomoko Maekawa, Masaaki Hori, Katsutoshi Murata, Thorsten Feiweier, Kouhei Kamiya, Christina Andica, Akifumi Hagiwara, Shohei Fujita, Saori Koshino, Toshiaki Akashi, Koji Kamagata, Akihiko Wada, Osamu Abe, Shigeki Aoki
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Journal Title
Magnetic Resonance Imaging
Volume: 72
Pages: 34-41
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Regional brain gray matter volume in world-class artistic gymnasts2020
Author(s)
Fukuo Makoto、Kamagata Koji、Kuramochi Mana、Andica Christina、Tomita Hiroyuki、Waki Hidefumi、Sugano Hidenori、Tange Yuichi、Mitsuhashi Takumi、Uchida Wataru、Takenaka Yuki、Hagiwara Akifumi、Harada Mutsumi、Goto Masami、Hori Masaaki、Aoki Shigeki、Naito Hisashi
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Journal Title
The Journal of Physiological Sciences
Volume: 70
Pages: 43-50
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ventricular volumetry and free-water corrected diffusion tensor imaging of the anterior thalamic radiation in idiopathic normal pressure hydrocephalus.2020
Author(s)
Saito A, Kamagata K, Ueda R, Nakazawa M, Andica C, Irie R, Nakajima M, Miyajima M, Hori M, Tanaka F, Arai H, Aoki S.
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Journal Title
Journal of Neuroradiology
Volume: 印刷中
Pages: 312-317
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Free-Water Imaging in White and Gray Matter in Parkinson's Disease2019
Author(s)
Andica C., Kamagata K., Hatano T., Saito A., Uchida W., Ogawa T., Takeshige-Amano H., Zalesky A., Wada A., Suzuki M., Hagiwara A., Irie R., Hori M., Kumamaru K. K., Oyama G., Shimo Y., Umemura A., Pantelis C., Hattori N., Aoki S.
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Journal Title
Cells
Volume: 8
Pages: 839-839
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] White matter alterations in adult with autism spectrum disorder evaluated using diffusion kurtosis imaging2019
Author(s)
Hattori A., Kamagata K., Kirino E., Andica C., Tanaka S., Hagiwara A., Fujita S., Maekawa T., Irie R., Kumamaru K. K., Suzuki M., Wada A., Hori M., Aoki S.
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Journal Title
Neuroradiology
Volume: -
Pages: 1343-1353
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Choroid plexus cysts analyzed using diffusion-weighted imaging with short diffusion-time2019
Author(s)
Tomoko Maekawa, Masaaki Hori, Katsutoshi Murata, Thorsten Feiweier, Christina Andica, Issei Fukunaga, Saori Koshino, Akifumi Hagiwara, Kouhei Kamiya, Koji Kamagata, Akihiko Wada, Osamu Abe, Shigeki Aoki
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Journal Title
Magn Reson Imaging
Volume: 57
Pages: 323-327
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The Relationship between Neurite Density Measured with Confocal Microscopy in a Cleared Mouse Brain and Metrics Obtained from Diffusion Tensor and Diffusion Kurtosis Imaging2018
Author(s)
Irie R., Kamagata K., Kerever A., Ueda R., Yokosawa S., Otake Y., Ochi H., Yoshizawa H., Hayashi A., Tagawa K., Okazawa H., Takahashi K., Sato K., Hori M., Arikawa-Hirasawa E., Aoki S.
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Journal Title
MRMS
Volume: 17
Issue: 2
Pages: 128-144
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access
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[Journal Article] Neurite orientation dispersion and density imaging of the nigrostriatal pathway in Parkinson's disease: Retrograde degeneration observed by tract-profile analysis.2018
Author(s)
Andica C, Kamagata K, Hatano T, Okuzumi A, Saito A, Nakazawa M, Ueda R, Motoi Y, Kamiya K, Suzuki M, Hori M, Kumamaru KK, Hattori N, Aoki S.
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Journal Title
Parkinsonism Relat Disord
Volume: 18
Pages: 30112-30113
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Myelin Measurement : Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods2018
Author(s)
Hagiwara A., Hori M., Kamagata K., Warntjes M., Matsuyoshi D., Nakazawa M., Ueda R., Andica C., Koshino S., Maekawa T., Irie R., Takamura T., Kumamaru K. K., Abe O., Aoki S.
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Journal Title
Sci Rep
Volume: 8
Pages: 10554-10554
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Diffusional kurtosis imaging and white matter microstructure modeling in a clinical study of major depressive disorder2018
Author(s)
Kamiya K., Okada N., Sawada K., Watanabe Y., Irie R., Hanaoka S., Suzuki Y., Koike S., Mori H., Kunimatsu A., Hori M., Aoki S., Kasai K., Abe O.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Changes in the ADC of diffusion-weighted MRI with the oscillating gradient spin-echo (OGSE) sequence due to differences in substrate viscosities2018
Author(s)
Tomoko Maekawa, Masaaki Hori, Katsutoshi Murata, Thorsten Feiweier, Issei Fukunaga, Christina Andica, Akifumi Hagiwara, Koji Kamagata, Saori Koshino, Osamu Abe, Shigeki Aoki
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Journal Title
Japanese Journal of Radiology
Volume: 36
Issue: 7
Pages: 415-420
DOI
NAID
ISSN
1867-1071, 1867-108X
Related Report
Peer Reviewed / Open Access
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[Journal Article] Spatial Restriction within Intracranial Epidermoid Cysts Observed Using Short Diffusion-time Diffusion-weighted Imaging2018
Author(s)
Christina Andica, Masaaki Hori, Kouhei Kamiya, Saori Koshino, Akifumi Hagiwara, Koji Kamagata, Issei Fukunaga, Nozomi Hamasaki, Michimasa Suzuki, Thorsten Feiweier, Katsutoshi Murata, Atsushi Arakawa, Akihide Kondo, Osamu Akiyama, Shigeki Aoki
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Journal Title
MRMS
Volume: 17
Issue: 3
Pages: 269-272
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Advantage of Synthetic MRI for the Visualization of Anterior Temporal Pole Lesions on Double Inversion Recovery (DIR), Phase-sensitive Inversion Recovery (PSIR), and Myelin Images in a Patient with CADASIL2018
Author(s)
Wallaert L, Hagiwara A, Andica C, Hori M, Yamashiro K, Koshino S, Maekawa T, Kamagata K, Aoki S.
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Journal Title
MRMS
Volume: 印刷中
Issue: 4
Pages: 275-276
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Differentiating Alzheimer's Disease from Dementia with Lewy Bodies Using a Deep Learning Technique Based on Structural Brain Connectivity.2018
Author(s)
Wada A, Tsuruta K, Irie R, Kamagata K, Maekawa T, Fujita S, Koshino S, Kumamaru K, Suzuki M, Nakanishi A, Hori M, Aoki S.
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Journal Title
Magn Reson Med Sci
Volume: 18
Pages: 1-6
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Comparison of cortical gray matter and subcortical gray matter using double diffusion encoding.2021
Author(s)
Shimpei Kato, Kouhei Kamiya, Koji Kamagata, Hiroshi Kusahara, Masahiro Abe, Shohei Fujita, Toshiaki Akashi, Katsuhiro Sano, Akihiko Wada, Masaaki Hori, Osamu Abe, Shigeki Aoki.
Organizer
ISMRM & SMRT Annual Meeting & Exhibition 2021
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[Presentation] An investigation of the change in water diffusivity along the perivascular space in hypertensive patients23592021
Author(s)
Junko Kikuta, Koji Kamagata, Kaito Takabayashi, Toshiaki Taoka, Hajime Yokota, Yuki Someya, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Shinji Naganawa, and Shigeki Aoki.
Organizer
ISMRM 29th annual meeting and exhibition
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[Presentation] Simultaneous morphometry and relaxometry of the human brain using three-dimensional MR fingerprinting at 1.5 and 3T.2021
Author(s)
Shohei Fujita, Matteo Cencini, Guido Buonincontri, Naoyuki Takei, Rolf F. Schulte, Wataru Uchida, Akifumi Hagiwara, Koji Kamagata, Osamu Abe, Michela Tosetti, and Shigeki Aoki.
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ISMRM 29th annual meeting and exhibition
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[Presentation] Prospective motion-corrected three-dimensional multiparametric mapping of the brain1371.2021
Author(s)
Shohei Fujita, Naoyuki Takei, Akifumi Hagiwara, Issei Fukunaga, Dan Rettmann, Suchandrima Banerjee, Ken-Pin Hwang, Shiori Amemiya, Koji Kamagata, Osamu Abe, and Shigeki Aoki.
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ISMRM 29th annual meeting and exhibition
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[Presentation] Radiomics with 3D MR fingerprinting: Influence of dictionary design on radiomic features and a potential mitigation strategy.2021
Author(s)
Shohei Fujita, Akifumi Hagiwara, Koichiro Yasaka, Hiroyuki Akai, Akira Kunimatsu, Shigeru Kiryu, Issei Fukunaga, Shimpei Kato, Toshiaki Akashi, Koji Kamagata, Akihiko Wada, Osamu Abe, and Shigeki Aoki.
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ISMRM 29th annual meeting and exhibition
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[Presentation] Free Water Eliminated White Matter Tract Integrity of Spinal Cord in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder3446.2021
Author(s)
Masaaki Hori, Kouhei Kamiya, Akifumi Hagiwara, Kazumasa Yokoyama, Issei Fukunaga, Katsuhiro Sano, Koji Kamagata, Katsutoshi Murata, Shohei Fujita, Christina Andica, Akihiko Wada, Julien Cohen-Adad, and Shigeki Aoki.
Organizer
ISMRM 29th annual meeting and exhibition,
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[Presentation] Microstructural Gray Matter Abnormalities in Progressive Supranuclear Palsy and Corticobasal Syndrome: Evaluation by Free-water Imaging.2021
Author(s)
Koji Kamagata, Christina Andica, Kaito Takabayashi, Yuya Saito, Wataru Uchida, Shohei Fujita, Toshiaki Akashi, Akihiko Wada, Kouhei Kamiya, Masaaki Hori, and Shigeki Aoki
Organizer
ISMRM 29th annual meeting and exhibition,
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[Presentation] 3D MR Fingerprinting による脳構造毎の組織緩和時間と形態情報の同時解析に関する網羅的検討2021
Author(s)
藤田翔平, Matteo Cencini, Guido Buonincontri, 竹井直行, 福永一星, 内田航, 萩原彰文, 鎌形康司, 阿部修, Michela Tosetti, 青木茂樹
Organizer
第49回 日本磁気共鳴医学会大会
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[Presentation] Radiomics with 3D MR fingerprinting: the influence of dictionary design on texture features and a way to mitigate it2020
Author(s)
Shohei Fujita, Koichiro Yasaka, Hiroyuki Akai, Akira Kunimatsu, Shigeru Kiryu, Issei Fukunaga, Shimpei Kato, Akifumi Hagiwara, Toshiaki Akashi, Koji Kamagata, Akihiko Wada, Osamu Abe, Shigeki Aoki.
Organizer
The 48th Annual Meeting of the JSMRM
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[Presentation] White matter integrity as a mediator in the relationship between polyunsaturated fatty acids and cognition in the elderly.2020
Author(s)
Koji Kamagata, Kazunori Shimada, Hideyoshi Kaga, Yuki Someya, Christina Andica, Yuya Saito, Toshiaki Akashi, Akihiko Wada, Yoshifumi Tamura, Ryuzo Kawamori, Hirotaka Watada, Hiroyuki Daida, Shigeki Aoki
Organizer
第48回日本磁気共鳴医学会大会
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[Presentation] Differentiation of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders by Convolutional Neural Network.2020
Author(s)
Hagiwara A, Otsuka Y, Andica C, Kato S, Yokoyama K, Hori M, Fujita S, Kamagata K, Irie R, Koshino S, Maekawa T, Akashi T, Wada A, Kumamaru K, Haruyama T, Murata S, Hattori N, Aoki S.
Organizer
International Society for Magnetic Resonance in Medicine Virtual Conference & Exhibition.
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[Presentation] Diffusion Time Dependence of Diffusion Tensor Parameters in the Evaluation of Meningioma Subtype: a Preliminary Study2019
Author(s)
Tomoko Maekawa, Masaaki Hori, Katsutoshi Murata, Christina Andica, Yutaka Ikenouchi, Shohei Fujita, Ryusuke Irie, Akifumi Hagiwara, Kamiya Kouhei, Koji Kamagata, Akihiko Wada, Shigeki Aoki
Organizer
ISMRM, Montreal, Canada
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Int'l Joint Research
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[Presentation] Differentiation of High-Grade and Low-Grade Intra-Axial Brain Tumors by Time- Dependent Diffusion MRI2019
Author(s)
Tomoko Maekawa, Masaaki Hori, Katsutoshi Murata, Kouhei Kamiya, Christina Andica, Akifumi Hagiwara, Shohei Fujita, Ryusuke Irie, Toshiaki Akashi, Koji Kamagata, Akihiko Wada, Shigeki Aoki
Organizer
第47回日本磁気共鳴医学会大会、熊本、2019.9.20-22
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[Presentation] Diffusion-weighted MRI with Oscillating Gradient Spin Echo (OGSE) sequence: Changes of ADC due to differences in the viscosity of substrates.2018
Author(s)
Maekawa T, Hori M, Fukunaga I, Murata K, Koshino S, Andica C, Irie R, Hagiwara A,Murata S, Hamasaki N, Horita M, Takenaka Y, Aoki S.
Organizer
The 6th international congress on magnetic resonance imaging & 23rd annual scientific meeting of KSMRM
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Int'l Joint Research
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[Presentation] White Matter Alterations in Parkinson’s Disease Analyzed with Combined Diffusion Magnetic Resonance Imaging and Magnetization Transfer Saturation Imaging: A Tract-Based Spatial Statistics Analysis.2018
Author(s)
Andica C, Kamagata K, Hatano T, Saito A, Takenaka Y, Hagiwara A, Hori M, Irie R, Wada A, Kumamaru K, Hattori N, Aoki S.
Organizer
Joint Annual Meeting ISMRM-ESMRMB2018
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Int'l Joint Research
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[Presentation] Oscillating gradient spin echo (OGSE) diffusion weighted imaging of the epidermoid cysts: simulation application.2018
Author(s)
Koshino S, Sakakibara A, Choppin A, Andica C, Hagiwara A, Maekawa T, Takemori A, Arakawa A, Chougar L, Hori M, Aoki S.
Organizer
Joint Annual Meeting ISMRM-ESMRMB2018
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Int'l Joint Research
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[Presentation] Rapid Myelin Measurement: Comparison Between SyMRI (Simultaneous Tissue Relaxometry), Magnetization Transfer Saturation Index, and T1w/T2w Ratio Methods.2018
Author(s)
Hagiwara A, Hori M, Kamagata K, Nakazawa M, Andica C, Maekawa T, Koshino S, Irie R, Chougar L, Abe O, Aoki S.
Organizer
Joint Annual Meeting ISMRM-ESMRMB2018
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Int'l Joint Research
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[Presentation] Diffusion kurtosis imaging and white matter model analysis of the brains of patients with major depressive disorder.2018
Author(s)
Kamiya K, Okada N, Sawada K, Watanabe Y, Irie R, Suzuki Y, Hanaoka S, Watadani T, Koike S, Mori H, Kunimatsu A, Hori M, Aoki S, Kasai K, Abe O.
Organizer
Joint Annual Meeting ISMRM-ESMRMB2018
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Int'l Joint Research
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[Presentation] Radiologic-Pathologic Correlation for Differential Diagnosis Using Diffusion MRI with a Short Diffusion Time.2018
Author(s)
Koshino S, Takemori M, Andica C, Hori M, Kamagata K,. Kumamaru KK, Wada A, Watadani T, Mori H, Abe O, Aoki S.
Organizer
Ragiological Society of North America 104th Scientific Assembly and Annual Meeting
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Int'l Joint Research
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