| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
In this study we developed a robust method to derive multi-cellular human liver organoids including immune components that exhibit resemblance to in vivo-derived tissues. Under free fatty acid treatment, the organoids recapitulated key features of steatohepatitis in a successive manner. Furthermore, organoids from patients of Wolman disease, which is a congenital steatohepatitis driven by loss-of-function mutation of lysosomal acid lipase, phenocopied severe steatohepatitis.
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