| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Accumulation of fat in visceral adipose tissue causes chronic inflammation due to infiltration of immune cells, mainly macrophages. We have found that osteopontin secreted by senescent T cells is involved in chronic inflammation in visceral adipose tissue. In the present study, we found that removal of senescent T cells by targeting PD-1 (Programmed cell death protein 1) improves glucose metabolism. This method would also remove activated T cells, which is not desirable. Regulation of transcriptional activity of osteopontin is important as a therapeutic target. We have been trying to clarify the mechanism of activation and regulation of the transcriptional activity of osteopontin, which is observed not only in visceral obesity but also in myocardial infarction and diabetic kidney disease.
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