|Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|Outline of Final Research Achievements
The aim of the current study is to identify a genetic factor responsible for the interstitial lung disease specific for Japanese. Recently, vulnerability of Japanese to interstitial lung diseases has been widely recognized. First, drug-induced interstitial lung disease occurs at a higher frequency in Japanese than people in other ethnic groups. Second, acute exacerbation is more frequently observed in the patients with interstitial pulmonary fibrosis. These conditions often occur in medical services, and hinders safe medical services. We decided to elucidate the genetic factors that cause interstitial lung diseases in Japanese, and thus help to contribute to a safer medical services. We compared the non-synonymous SNPs in patients and healthy people and identified the MUC4 gene as a candidate gene.