|Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
|Outline of Final Research Achievements
For analysis of the role of aerobic ATP production in skeletogenesis, we generated Tfam conditional knockout mice. These mice exhibited spontaneous bone fracture within a week after birth. In contrast, LDHA conditional knock out mice exhibited severe growth plate deformity. These data showed that during osteogenesis, aerobic ATP production by mitochondria is critical, and that during chondrogenesis, anaerobic ATP production is indispensable.