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Elucidation of mechanism for the enhancement of osteoclast differentiation under hypoxia and development of new therapeutic approach for bone resorption in rheumatoid arthritis

Research Project

Project/Area Number 18H02926
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionKyoto University

Principal Investigator

Murata Koichi  京都大学, 医学研究科, 特定助教 (60806793)

Co-Investigator(Kenkyū-buntansha) 吉富 啓之  京都大学, 医学研究科, 准教授 (50402920)
寺尾 知可史  国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー (60610459)
伊藤 宣  京都大学, 医学研究科, 特定教授 (70397537)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords破骨細胞 / 低酸素 / 関節リウマチ / 骨粗鬆症 / 炎症性疾患 / SNP
Outline of Final Research Achievements

The purpose of this study was to comprehensively elucidate the mechanism of promoting osteoclast differentiation under hypoxia and to search for a therapeutic method for bone destruction specific to rheumatoid arthritis. We found that KDM1a is important using specific siRNAs and inhibitors. KDM1a is mTOR-dependently induced by RANKL stimulation during osteoclastogenesis. KDM1a regulated metabolism in HIF1-mediated osteoclast differentiation not only under hypoxia but also under normoxia. Furthermore, it regulated the expression of E2F1 regulating the cell cycle and metabolism in osteoclast differentiation. The HIF-mediated osteoclast differentiation pathway of KDM1a was found to be important in inflammatory bone resorption, including rheumatoid arthritis.

Academic Significance and Societal Importance of the Research Achievements

関節リウマチは炎症性疾患で、骨軟骨破壊を来して、機能障害を引き起こす。近年様々な薬剤が開発されたものの、骨破壊は完全には制御できておらず、既存の治療は副作用や長期使用に問題がある。今回、骨を破壊する細胞の主軸である破骨細胞の分化において、KDM1aが重要であることが分かった。KDM1aを介した炎症部位特異的な骨破壊の機序が明らかになり、今後関節リウマチの新たな骨破壊の治療法になる可能性がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (47 results)

All 2021 2020 2019 2018

All Journal Article (30 results) (of which Peer Reviewed: 30 results,  Open Access: 14 results) Presentation (17 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Predictive Value of Heterogeneously Enhanced Magnetic Resonance Imaging Findings With Computed Tomography Evidence of Calcification for Severe Motor Deficits in Spinal Meningioma2021

    • Author(s)
      Ono Kosei、Shimizu Takayoshi、Fujibayashi Shunsuke、Otsuki Bungo、Murata Koichi、Sakamoto Akio、Matsuda Shuichi
    • Journal Title

      Neurospine

      Volume: 18 Issue: 1 Pages: 163-169

    • DOI

      10.14245/ns.2040494.247

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Letter to the Editor concerning “Impact of spinal alignment and stiffness on impingement after total hip arthroplasty: a radiographic study of pre? and post?operative spinopelvic alignment” by Hagiwara S, et al.2020

    • Author(s)
      Murata Koichi、Otsuki Bungo、Fujibayashi Shunsuke、Shimizu Takayoshi、Matsuda Shuichi
    • Journal Title

      European Spine Journal

      Volume: 29 Issue: 12 Pages: 3245-3246

    • DOI

      10.1007/s00586-020-06633-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluctuation in anti-cyclic citrullinated protein antibody level predicts relapse from remission in rheumatoid arthritis: KURAMA cohort2020

    • Author(s)
      Murata Koichi、Ito Hiromu、Hashimoto Motomu、Murakami Kosaku、Watanabe Ryu、Tanaka Masao、Yamamoto Wataru、Matsuda Shuichi
    • Journal Title

      Arthritis Research & Therapy

      Volume: 22 Issue: 1 Pages: 268-268

    • DOI

      10.1186/s13075-020-02366-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The limitations of mono‐ and combination antibiotic therapies on immature biofilms in a murine model of implant‐associated osteomyelitis2020

    • Author(s)
      Tomizawa Takuya、Nishitani Kohei、Ito Hiromu、Okae Yu、Morita Yugo、Doi Kohei、Saito Motoo、Ishie Shinichiro、Yoshida Shigeo、Murata Koichi、Yoshitomi Hiroyuki、Kuroda Yutaka、Matsuda Shuichi
    • Journal Title

      Journal of Orthopaedic Research

      Volume: 39 Issue: 2 Pages: 449-457

    • DOI

      10.1002/jor.24956

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis.2020

    • Author(s)
      Saito M, Nishitani K, Ikeda HO, Yoshida S, Iwai S, Ji X, Nakahata A, Ito A, Nakamura S, Kuriyama S, Yoshitomi H, Murata K, Aoyama T, Ito H, Kuroki H, Kakizuka A, Matsuda S.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 20787-20787

    • DOI

      10.1038/s41598-020-77735-2

    • NAID

      120006940250

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term Radiographic Outcome of Occipitocervical Fixation2020

    • Author(s)
      Shimizu Takayoshi、Fujibayashi Shunsuke、Otsuki Bungo、Takemoto Mitsuru、Murata Koichi、Matsuda Shuichi
    • Journal Title

      Spine

      Volume: 46 Issue: 3 Pages: 152-159

    • DOI

      10.1097/brs.0000000000003757

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cervical Myelopathy Caused by Invagination of Floating Anomalous C2 and C3 Laminae in the Spinal Canal2020

    • Author(s)
      Nakashima Takaki、Otsuki Bungo、Shimizu Takayoshi、Fujibayashi Shunsuke、Murata Koichi、Matsuda Shuichi
    • Journal Title

      Spine Surgery and Related Research

      Volume: 4 Issue: 3 Pages: 274-276

    • DOI

      10.22603/ssrr.2019-0073

    • NAID

      130007881350

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the efficacy and safety of biologic agents between elderly-onset and young-onset RA patients: the ANSWER cohort study2020

    • Author(s)
      Jinno Sadao、Onishi Akira、Dubreuil Maureen、Akashi Kengo、Hashimoto Motomu、Yamamoto Wataru、Murata Koichi、Takeuchi Tohru、Kotani Takuya、Maeda Yuichi、Ebina Kosuke、Son Yonsu、Amuro Hideki、Hara Ryota、Katayama Masaki、Saegusa Jun、Morinobu Akio
    • Journal Title

      Rheumatology International

      Volume: 40 Issue: 12 Pages: 1987-1995

    • DOI

      10.1007/s00296-020-04660-y

    • NAID

      120006897895

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the Factors Affecting Lumbar Segmental Lordosis After Lateral Lumbar Interbody Fusion2020

    • Author(s)
      Otsuki Bungo、Fujibayashi Shunsuke、Takemoto Mitsuru、Kimura Hiroaki、Shimizu Takayoshi、Murata Koichi、Matsuda Shuichi
    • Journal Title

      Spine

      Volume: 45 Issue: 14 Pages: E839-E846

    • DOI

      10.1097/brs.0000000000003432

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug retention of 7 biologics and tofacitinib in biologics-na?ve and biologics-switched patients with rheumatoid arthritis: the ANSWER cohort study2020

    • Author(s)
      Ebina Kosuke、Hirano Toru、Maeda Yuichi、Yamamoto Wataru、Hashimoto Motomu、Murata Koichi、Takeuchi Tohru、Shiba Hideyuki、Son Yonsu、Amuro Hideki、Onishi Akira、Akashi Kengo、Hara Ryota、Katayama Masaki、Yamamoto Keiichi、Kumanogoh Atsushi、Hirao Makoto
    • Journal Title

      Arthritis Research & Therapy

      Volume: 22 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s13075-020-02232-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Indirect Decompression Through Oblique Lateral Interbody Fusion for Revision Surgery After Lumbar Decompression2020

    • Author(s)
      Shimizu Takayoshi、Fujibayashi Shunsuke、Otsuki Bungo、Murata Koichi、Matsuda Shuichi
    • Journal Title

      World Neurosurgery

      Volume: 141 Pages: e389-e399

    • DOI

      10.1016/j.wneu.2020.05.151

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repair of Iliac Crest Defects with a Hydroxyapatite/Collagen Composite2020

    • Author(s)
      Murata Koichi、Fujibayashi Shunsuke、Otsuki Bungo、Shimizu Takayoshi、Matsuda Shuichi
    • Journal Title

      Asian Spine Journal

      Volume: 14 Issue: 6 Pages: 808-813

    • DOI

      10.31616/asj.2019.0310

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cervical spinal computed tomography utilizing model-based iterative reconstruction reduces radiation to an equivalent of three cervical X-rays2020

    • Author(s)
      Masamoto Kazutaka、Fujibayashi Shunsuke、Otsuki Bungo、Fukushima Yasuhiro、Koizumi Koji、Shimizu Takayoshi、Shimizu Yu、Murata Koichi、Ikeda Norimasa、Matsuda Shuichi
    • Journal Title

      European Spine Journal

      Volume: 29 Issue: 11 Pages: 2804-2813

    • DOI

      10.1007/s00586-020-06426-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A?cross-sectional study using the KURAMA database2020

    • Author(s)
      Minamino Hiroto、Katsushima Masao、Yoshida Tamami、Hashimoto Motomu、Fujita Yoshihito、Shirakashi Mirei、Yamamoto Wataru、Murakami Kosaku、Murata Koichi、Nishitani Kohei、Tanaka Masao、Ito Hiromu、Inagaki Nobuya、Matsuda Shuichi
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 3 Pages: 0229998-0229998

    • DOI

      10.1371/journal.pone.0229998

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accuracy of fluoroscopic guidance with the coaxial view of the pedicle for percutaneous insertion of lumbar pedicle screws and risk factors for pedicle breach2020

    • Author(s)
      Murata Koichi、Fujibayashi Shunsuke、Otsuki Bungo、Shimizu Takayoshi、Masamoto Kazutaka、Matsuda Shuichi
    • Journal Title

      Journal of Neurosurgery: Spine

      Volume: 1 Issue: 1 Pages: 1-8

    • DOI

      10.3171/2020.5.spine20291

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis.2020

    • Author(s)
      Murakami K, Murakami I*, Hashimoto M, Tanaka M, Ito H, Fujii T, Torii M, Ikeda K, Kuwabara A, Tanaka K, Yoshida A, Akizuki S, Nakashima R, Yoshifuji H, Ohmura K, Usui T, Morita S, Mimori T
    • Journal Title

      PLoS One

      Volume: 15 Issue: 2 Pages: 0228852-0228852

    • DOI

      10.1371/journal.pone.0228852

    • NAID

      120006993973

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drug tolerability and reasons for discontinuation of seven biologics in elderly patients with rheumatoid arthritis -The ANSWER cohort study-2019

    • Author(s)
      Ebina Kosuke、Hashimoto Motomu、Yamamoto Wataru、Hirano Toru、Hara Ryota、Katayama Masaki、Onishi Akira、Nagai Koji、Son Yonsu、Amuro Hideki、Yamamoto Keiichi、Maeda Yuichi、Murata Koichi、Jinno Sadao、Takeuchi Tohru、Hirao Makoto、Kumanogoh Atsushi、Yoshikawa Hideki
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 5 Pages: 0216624-0216624

    • DOI

      10.1371/journal.pone.0216624

    • NAID

      120006879476

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drug tolerability and reasons for discontinuation of seven biologics in 4466 treatment courses of rheumatoid arthritis?the ANSWER cohort study2019

    • Author(s)
      Ebina Kosuke、Hashimoto Motomu、Yamamoto Wataru、Hirano Toru、Hara Ryota、Katayama Masaki、Onishi Akira、Nagai Koji、Son Yonsu、Amuro Hideki、Yamamoto Keiichi、Maeda Yuichi、Murata Koichi、Jinno Sadao、Takeuchi Tohru、Hirao Makoto、Kumanogoh Atsushi、Yoshikawa Hideki
    • Journal Title

      Arthritis Research & Therapy

      Volume: 21 Issue: 1 Pages: 91-91

    • DOI

      10.1186/s13075-019-1880-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of Immune Responses and Chronic Inflammation by Fibroblast-Like Synoviocytes2019

    • Author(s)
      Yoshitomi Hiroyuki
    • Journal Title

      Frontiers in Immunology

      Volume: 10 Pages: 1395-1395

    • DOI

      10.3389/fimmu.2019.01395

    • NAID

      120006786922

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Shared epitope defines distinct associations of cigarette smoking with levels of anticitrullinated protein antibody and rheumatoid factor2019

    • Author(s)
      Ishikawa Yuki、Ikari Katsunori、Hashimoto Motomu、Ohmura Koichiro、Tanaka Masao、Ito Hiromu、Taniguchi Atsuo、Yamanaka Hisashi、Mimori Tsuneyo、Terao Chikashi
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 78 Issue: 11 Pages: 1480-1487

    • DOI

      10.1136/annrheumdis-2019-215463

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Does Abatacept Increase Postoperative Adverse Events in Rheumatoid Arthritis Compared with Conventional Synthetic Disease-modifying Drugs?2019

    • Author(s)
      Ito Hiromu、Tsuji Shigeyoshi、Nakayama Masanori、Mochida Yuichi、Nishida Keiichiro、Ishikawa Hajime、Kojima Toshihisa、Matsumoto Takumi、Kubota Ayako、Mochizuki Takeshi、Sakuraba Koji、et al.、the JOSRA Consortium
    • Journal Title

      The Journal of Rheumatology

      Volume: 47 Issue: 4 Pages: 502-509

    • DOI

      10.3899/jrheum.181100

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of risk factors for atherosclerosis using carotid ultrasonography in Japanese patients with rheumatoid arthritis2019

    • Author(s)
      Yamamoto Hiroko、Nakajima Toshiki、Kawahara Rie、Nakabo Shuichiro、Hashimoto Motomu、Yamamoto Wataru、Masuda Izuru、Ito Hiromu、Mimori Tsuneyo、Fujii Yasutomo
    • Journal Title

      International Journal of Rheumatic Diseases

      Volume: 22 Issue: 7 Pages: 1312-1318

    • DOI

      10.1111/1756-185x.13591

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strain-specific manifestation of lupus-like systemic autoimmunity caused by ZAP70 mutation2019

    • Author(s)
      Takashi Matsuo, Motomu Hashimoto, Shimon Sakaguchi, Noriko Sakaguchi, Yoshinaga Ito, Masaki Hikida, Tatsuaki Tsuruyama, Kaoru Sakai, Hideki Yokoi, Mirei Shirakashi, Masao Tanaka, Hiromu Ito, Hajime Yoshifuji, Koichiro Ohmura, Takao Fujii, and Tsuneyo Mimori
    • Journal Title

      The Journal of Immunology

      Volume: 印刷中 Issue: 11 Pages: 3161-3172

    • DOI

      10.4049/jimmunol.1801159

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elderly onset of early rheumatoid arthritis is a risk factor for bone erosions, refractory to treatment: KURAMA cohort.2018

    • Author(s)
      Murata K, Ito H, Hashimoto M, Nishitani K, Murakami K, Tanaka M, Yamamoto W, Mimori T, Matsuda S
    • Journal Title

      Int J Rheum Dis.

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments.2018

    • Author(s)
      Yoshitomi H, Kobayashi S, Miyagawa-Hayashino A, Okahata A, Doi K, Nishitani K, Murata K, Ito H, Tsuruyama T, Haga H, Matsuda S, Toguchida J
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 3762-3762

    • DOI

      10.1038/s41467-018-06187-0

    • NAID

      120006523829

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation Between Intraoperative Anterior Stability and Flexion Gap in Total Knee Arthroplasty2018

    • Author(s)
      Nakamura Shinichiro、Kuriyama Shinichi、Nishitani Kohei、Ito Hiromu、Murata Koichi、Matsuda Shuichi
    • Journal Title

      The Journal of Arthroplasty

      Volume: 33 Issue: 8 Pages: 2480-2484

    • DOI

      10.1016/j.arth.2018.03.030

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of medication adherence on disease activity among Japanese patients with rheumatoid arthritis2018

    • Author(s)
      Nakagawa S, Nakaishi M, Hashimoto M, Ito H, Yamamoto W, Nakashima R, Tanaka M, Fujii T, Omura T, Imai S, Nakagawa T, Yonezawa A, Imai H, Mimori T, Matsubara K.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 11 Pages: e0206943-e0206943

    • DOI

      10.1371/journal.pone.0206943

    • NAID

      120006539574

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors associated with the achievement of biological disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: the ANSWER cohort study2018

    • Author(s)
      Hashimoto Motomu、Furu Moritoshi、Yamamoto Wararu、Fujimura Takanori、Hara Ryota、Katayama Masaki、Ohnishi Akira、Akashi Kengo、Yoshida Shuzo、Nagai Koji、Son Yonsu、Amuro Hideki、Hirano Toru、Ebina Kosuke、Uozumi Ryuji、Ito Hiromu、Tanaka Masao、Ohmura Koichiro、Fujii Takao、Mimori Tsuneyo
    • Journal Title

      Arthritis Research & Therapy

      Volume: 20 Issue: 1

    • DOI

      10.1186/s13075-018-1673-1

    • NAID

      120006501233

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis.2018

    • Author(s)
      Terao C, Yoshifuji H, Matsumura T, Naruse TK, Ishii T, Nakaoka Y, Kirino Y, Matsuo K, Origuchi T, Shimizu M, Maejima Y, Amiya E, Tamura N, Kawaguchi T, Takahashi M, Setoh K, Ohmura K, Watanabe R, Horita T, Atsumi T, Matsukura M, Miyata T, et al.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 115 Issue: 51 Pages: 13045-13050

    • DOI

      10.1073/pnas.1808850115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significant joint-destructive association of HLA-DRB1*04:05 independent of DAS28 in rheumatoid arthritis2018

    • Author(s)
      Tsuji Hideaki、Ikari Katsunori、Ohmura Koichiro、Yano Koichiro、Furu Moritoshi、Hashimoto Motomu、Ito Hiromu、Fujii Takao、Yamamoto Wataru、Taniguchi Atsuo、Yamanaka Hisashi、Mimori Tsuneyo、Terao Chikashi
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 78 Issue: 2 Pages: 284-286

    • DOI

      10.1136/annrheumdis-2018-214022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Real-world effectiveness of denosumab on clinical fracture reduction in patients with rheumatoid arthritis-ANSWER cohort study2020

    • Author(s)
      Koichi Murata, Motomu Hashimoto, Kosuke Ebina, Kengo Akashi, Akira Onishi, Koji Nagai, Ayaka Yoshikawa, Masaki Katayama, Yonsu Son, Hideki Amuro, Ryota Hara, Wataru Yamamoto, Kosaku Murakami, Masao Tanaka, Hiromu Ito, and Shuichi Matsuda
    • Organizer
      第64回日本リウマチ学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] デノスマブの使用は関節温存足趾形成術において骨癒合を遷延させうる2020

    • Author(s)
      村田 浩一、伊藤 宣、西谷 江平、橋本 求、村上 孝作、田中 真生、松田 秀一
    • Organizer
      第64回日本リウマチ学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 関節リウマチ患者に対するデノスマブ使用による 骨折低減効果 -ANSWER Cohortデータでの検討2020

    • Author(s)
      村田 浩一、橋本 求、蛯名 耕介、明石 健吾、大西 輝、永井 孝治、吉川 紋佳、片山 昌紀、孫 瑛洙、安室 秀樹、原 良太、山本 渉、村上 孝作、田中 真生、伊藤 宣、松田 秀一
    • Organizer
      第39回日本骨代謝学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 光超音波イメージングによる関節リウマチ手指関節滑膜の可視化2019

    • Author(s)
      村田 浩一、布留 守敏、伊藤 宣、橋本 求、田中 真生、西谷 江平、村上 孝作、三森 経世、松田 秀一
    • Organizer
      第63回日本リウマチ学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 関節リウマチの家族歴は病初期の疾患活動性や治療の反応性に影響するか -ANSWER Cohortデータでの検討2019

    • Author(s)
      村田 浩一、橋本 求、孫 瑛洙、安室 秀樹、永井 孝治、武内 徹、片山 昌紀、前田 悠一、蛯名 耕介、原 良太、神野 定男、大西 輝、山本 渉、村上 孝作、田中 真生、伊藤 宣、三森 経世、松田 秀一
    • Organizer
      第63回日本リウマチ学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] COMMD1は低酸素依存性に破骨細胞分化に関与し、関節リウマチの骨破壊を制御する2019

    • Author(s)
      村田 浩一
    • Organizer
      第92回日本整形外科学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高齢発症の関節リウマチの病初期において臨床的寛解でも骨破壊を完全には抑制できない2019

    • Author(s)
      村田 浩一、伊藤 宣、橋本 求、田中 真生、西谷 江平、村上 孝作、三森 経世、松田 秀一
    • Organizer
      第92回日本整形外科学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 関節リウマチの家族歴は病初期の疾患活動性や治療の反応性に影響するか -ANSWER Cohortデータでの検討2019

    • Author(s)
      村田 浩一、橋本 求、孫 瑛洙、安室 秀樹、永井 孝治、武内 徹、片山 昌紀、前田 悠一、蛯名 耕介、原 良太、神野 定男、大西 輝、山本 渉、村上 孝作、田中 真生、伊藤 宣、三森 経世、松田 秀一
    • Organizer
      第5回日本骨免疫学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Hypoxia-sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Osteoclast Precursors and Suppresses Osteoclastogenesis2019

    • Author(s)
      Koichi Murata, Chikashi Terao, Hiromu Ito, Koichiro Ohmura, Tsuneyo Mimori, Shuichi Matsuda, Kyung-Hyun Park-Min, and Lionel B. Ivashkiv
    • Organizer
      第16回bone biology forum
    • Related Report
      2019 Annual Research Report
  • [Presentation] Denosumab may delay bone healing in joint-preserving foot arthroplasty in rheumatoid arthritis2019

    • Author(s)
      Koichi Murata, Hiromu Ito, Kohei Nishitani, Shuichi Matsuda
    • Organizer
      RCOST2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 関節リウマチの発症年齢は病初期の疾患活動性やTNF阻害剤の反応性に影響する2018

    • Author(s)
      村田 浩一、伊藤 宣、橋本 求、田中 真生、西谷 江平、村上 孝作、三森 経世、松田 秀一
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] COMMD1は低酸素依存性に破骨細胞分化に関与し、関節リウマチの骨破壊を制御する2018

    • Author(s)
      村田 浩一、寺尾 知可史、伊藤 宣、大村 浩一郎、松田 秀一、三森 経世、松田 文彦、Park-min Kyung-hyung、Lionel B. Ivashkiv
    • Organizer
      第91回日本整形外科学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 関節リウマチの発症年齢は病初期の疾患活動性や薬剤の反応性に影響する2018

    • Author(s)
      村田 浩一、伊藤 宣、橋本 求、田中 真生、西谷 江平、村上 孝作、三森 経世、松田 秀一
    • Organizer
      第91回日本整形外科学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Hypoxia-sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Osteoclast Precursors and Suppresses Osteoclastogenesis2018

    • Author(s)
      Koichi Murata, Chikashi Terao, Hiromu Ito, Koichiro Ohmura, Tsuneyo Mimori, Shuichi Matsuda, Kyung-Hyun Park-Min, and Lionel B. Ivashkiv
    • Organizer
      7th international conference on osteoimmunology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高齢発症の関節リウマチは薬剤の良好な反応性にも関わらず骨破壊の危険因子である2018

    • Author(s)
      村田 浩一、伊藤 宣、橋本 求、田中 真生、西谷 江平、村上 孝作、三森 経世、松田 秀一
    • Organizer
      第4回日本骨免疫学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] COMMD1は低酸素依存性に破骨細胞分化に関与し、関節リウマチの骨破壊を制御する2018

    • Author(s)
      村田 浩一、寺尾 知可史、伊藤 宣、大村 浩一郎、松田 秀一、三森 経世、松田 文彦、Park-min Kyung-hyung、Lionel B. Ivashkiv
    • Organizer
      第36回日本骨代謝学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] COMMD1は低酸素依存性に破骨細胞分化に関与し、関節リウマチの骨破壊を制御する2018

    • Author(s)
      村田 浩一、寺尾 知可史、伊藤 宣、大村 浩一郎、松田 秀一、三森 経世、松田 文彦、Park-min Kyung-hyung、Lionel B. Ivashkiv
    • Organizer
      第33回日本整形外科学科学会基礎学術集会
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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