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Development of novel therapeutic modality by integrated analysis of immune environment of renal cell carcinoma and remodeling after inhibition of angiogenesis

Research Project

Project/Area Number 18H02939
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56030:Urology-related
Research InstitutionKeio University

Principal Investigator

OYA Mototsugu  慶應義塾大学, 医学部(信濃町), 教授 (00213885)

Co-Investigator(Kenkyū-buntansha) 三上 修治  慶應義塾大学, 医学部(信濃町), 講師 (20338180)
小坂 威雄  慶應義塾大学, 医学部(信濃町), 講師 (30445407)
水野 隆一  慶應義塾大学, 医学部(信濃町), 准教授 (60383824)
田中 伸之  慶應義塾大学, 医学部(信濃町), 講師 (60445244)
浅沼 宏  慶應義塾大学, 医学部(信濃町), 准教授 (70245570)
菊地 栄次  慶應義塾大学, 医学部(信濃町), 准教授 (10286552)
篠島 利明  慶應義塾大学, 医学部(信濃町), 講師 (60306777)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords腎細胞癌 / 分子標的治療 / 血管新生 / 耐性 / 免疫治療
Outline of Final Research Achievements

Renal cell carcinoma is a pioneer in cancer immunotherapy. In the immunohistological study, an automatic analysis platform was applied for cellular analysis to uncover the immunomicroenvironment of renal cell carcinoma tissue with a total of more than 10,000 spots. Furthermore, analyzing next-generation immune checkpoint molecules: LAG3/TIM3/TIGIT expression revealed that the malignancy of renal cell carcinoma can be stratified. Using the latest spectrum microscopy, we revealed tumor-specific CD39+PD-1+CD8+T cells and PD-1+Treg cells in proximity within renal cell carcinoma tissue, which may be one of reasons for a rapid disease progression after PD-1 treatment. In this study, we finally proceeded with the construction of a cancer immunogenomics atlas using tissue specimens of renal cell carcinoma as a prospective study.

Academic Significance and Societal Importance of the Research Achievements

進行腎細胞癌治療のオプションは、血管新生阻害薬・mTOR阻害薬等の分子標的治療薬に加えて、免疫チェックポイント阻害薬が登場したことで、研究の趨勢はどの薬剤をどういう順序でどのように投与するかという治療シークエンスとより強い抗腫瘍効果を求めての併用療法の開発に関心が移っている。医療経済を考慮しての個別化医療の方向性もあり、治療効果を予測するバイオマーカー開発は、社会的に意義深いと考える。分子標的治療薬や免疫チェックポイント阻害薬の耐性機序の研究も、新規治療の探索には不可欠である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(45 results)

All 2021 2020 2019 2018 Other

All Journal Article (34 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 34 results,  Open Access: 29 results) Presentation (10 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Journal Article] fficacy and safety of darolutamide in Japanese patients with nonmetastatic castration-resistant prostate cancer: a sub-group analysis of the phase III ARAMIS trial.2021

    • Author(s)
      Uemura H, Matsushima H, Kobayashi K, Mizusawa H, Nishimatsu H, Fizazi K, Smith M, Shore N, Tammela T, Tabata KI, Matsubara N, Iinuma M, Uemura H, Oya M, Momma T, Kawakita M, Fukasawa S, Kobayashi T, Kuss I, Le Berre MA, Snapir A, Sarapohja T, Suzuki K.
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Pages: 578-590

    • DOI

      10.1007/s10147-020-01824-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The efficacy of the TachoSil binding suturing technique in laparoscopic partial nephrectomy to prevent the development of pseudoaneurysm2020

    • Author(s)
      Shigeta Keisuke、Matsumoto Kazuhiro、Abe Takayuki、Komatsuda Akari、Takeda Toshikazu、Mizuno Ryuichi、Kikuchi Eiji、Asanuma Hiroshi、Arita Yuki、Akita Hirotaka、Jinzaki Masahiro、Miyajima Akira、Oya Mototsugu
    • Journal Title

      Asian Journal of Surgery

      Volume: 43 Pages: 668-675

    • DOI

      10.1016/j.asjsur.2019.09.002

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Real-world use of temsirolimus in Japanese patients with unresectable or metastatic renal cell carcinoma: recent consideration based on the results of a post-marketing, all-case surveillance study2020

    • Author(s)
      Sugiyama Shigeru、Sato Kazuo、Shibasaki Yoshiyuki、Endo Yutaka、Uryu Taku、Toyoshima Yasuharu、Oya Mototsugu、Miyanaga Naoto、Saijo Nagahiro、Gemma Akihiko、Akaza Hideyuki
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 50 Pages: 940-947

    • DOI

      10.1093/jjco/hyaa062

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sunitinib Versus Sorafenib as Initial Targeted Therapy for mCC-RCC With Favorable/Intermediate Risk: Multicenter Randomized Trial CROSS-J-RCC2020

    • Author(s)
      Tomita Yoshihiko、Naito Sei、Sassa Naoto、Takahashi Atsushi、Kondo Tsunenori、Koie Takuya、Obara Wataru、Kobayashi Yasuyuki、Teishima Jun、Takahashi Masayuki、Matsuyama Hideyasu、Ueda Takeshi、Yamaguchi Kenya、Kishida Takeshi、Shiroki Ryoichi、Saika Takashi、Shinohara Nobuo、Oya Mototsugu、Kanayama Hiro-omi
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: 18

    • DOI

      10.1016/j.clgc.2020.01.001

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of tumor microenvironment in acquiring resistance to vascular endothelial growth factor‐tyrosine kinase inhibitor and recent advance of systemic treatment of clear cell renal cell carcinoma2020

    • Author(s)
      Mikami Shuji、Mizuno Ryuichi、Kosaka Takeo、Tanaka Nobuyuki、Kuroda Naoto、Nagashima Yoji、Okada Yasunori、Oya Mototsugu
    • Journal Title

      Pathology International

      Volume: 70 Pages: 712-723

    • DOI

      10.1111/pin.12984

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proton pump inhibitors may hinder hypophosphatemic effect of lanthanum carbonate, but not of ferric citrate hydrate or sucroferric oxyhydroxide, in hemodialysis patients2020

    • Author(s)
      Minakuchi Hitoshi、Yoshida Tadashi、Kaburagi Noriko、Fujino Teppei、Endo Sho、Takemitsu Tomoko Yamashita、Yamashita Norimasa、Itoh Hiroshi、Oya Mototsugu
    • Journal Title

      Renal Failure

      Volume: 42 Pages: 799-806

    • DOI

      10.1080/0886022x.2020.1803085

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model2020

    • Author(s)
      Morita Shinya、Shinoda Kazunobu、Yoshida Tadashi、Shimoda Masayuki、Kanno Yoshihiko、Mizuno Ryuichi、Kono Hidaka、Asanuma Hiroshi、Nakagawa Ken、Umezawa Kazuo、Oya Mototsugu
    • Journal Title

      BMC Pharmacology and Toxicology

      Volume: 21 Pages: 1-12

    • DOI

      10.1186/s40360-020-00432-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cabozantinib in advanced renal cell carcinoma: A phase?II, open‐label, single‐arm study of Japanese patients2020

    • Author(s)
      Tomita Yoshihiko、Tatsugami Katsunori、Nakaigawa Noboru、Osawa Takahiro、Oya Mototsugu、Kanayama Hiroomi、Nakayama Kondoh Chihiro、Sassa Naoto、Nishimura Kazuo、Nozawa Masahiro、Masumori Naoya、Miyoshi Yasuhide、Kuroda Shingo、Tanaka Shingo、Kimura Akiko、Tamada Satoshi
    • Journal Title

      International Journal of Urology

      Volume: 27 Pages: 952-959

    • DOI

      10.1111/iju.14329

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difficulty in differential diagnosis for renal cancer with microscopic papillary architecture: overlapped pathological features among papillary renal cell carcinoma (RCC), mutinous tubular and spindle cell carcinoma, and unclassified RCC. Lessons from a Japanese multicenter study2020

    • Author(s)
      Ito Keiichi、Mikami Shuji、Kuroda Naoto、Nagashima Yoji、Tatsugami Katsunori、Masumori Naoya、Kondo Tsunenori、Takagi Toshio、Nakanishi Shotaro、Eto Masatoshi、Kamba Tomomi、Tomita Yoshihiko、Matsuyama Hideyasu、Tsushima Tomoyasu、Nakazawa Hayakazu、Oya Mototsugu、Kimura Go、Shinohara Nobuo、Asano Tomohiko
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 50 Pages: 1313-1320

    • DOI

      10.1093/jjco/hyaa114

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Risk-based Approach Simulating Oncological Surveillance After Radical Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma2020

    • Author(s)
      Shigeta Keisuke、Kikuchi Eiji、Abe Takayuki、Hagiwara Masayuki、Ogihara Koichiro、Anno Tadatsugu、Umeda Kota、Baba Yuto、Sanjo Tansei、Shojo Kazunori、Mikami Shuji、Mizuno Ryuichi、Oya Mototsugu
    • Journal Title

      European Urology Oncology

      Volume: 3 Pages: 756-763

    • DOI

      10.1016/j.euo.2019.06.021

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prioritising Urological Surgery in the COVID-19 Era: A Global Reflection on Guidelines2020

    • Author(s)
      Gravas Stavros、Fournier Georges、Oya Mototsugu、Summerton Duncan、Scarpa Roberto Mario、Chlosta Piotr、Gkialas Ioannis、Xie Li-Ping、Rasyid Nur、Bolton Damien、Gomez Reynaldo、Klotz Laurence、Kulkarni Sanjay、Tanguay Simon、de la Rosette Jean
    • Journal Title

      European Urology Focus

      Volume: 6 Pages: 1104-1110

    • DOI

      10.1016/j.euf.2020.06.006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies2020

    • Author(s)
      Tanaka Nobuyuki、Kanatani Shigeaki、Kaczynska Dagmara、Fukumoto Keishiro、Louhivuori Lauri、Mizutani Tomohiro、Kopper Oded、Kronqvist Pauliina、Robertson Stephanie、Lindh Claes、Kis Lorand、Pronk Robin、Niwa Naoya、Matsumoto Kazuhiro、Oya Mototsugu、... Uhlen Per
    • Journal Title

      Nature Biomedical Engineering

      Volume: 4 Pages: 875-888

    • DOI

      10.1038/s41551-020-0576-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Role of the MUC1‐C oncoprotein in the acquisition of cisplatin resistance by urothelial carcinoma2020

    • Author(s)
      Shigeta Keisuke、Hasegawa Masanori、Kikuchi Eiji、Yasumizu Yota、Kosaka Takeo、Mizuno Ryuichi、Mikami Shuji、Miyajima Akira、Kufe Donald、Oya Mototsugu
    • Journal Title

      Cancer Science

      Volume: 111 Pages: 3639-3652

    • DOI

      10.1111/cas.14574

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A comparison of laparoendoscopic single-site surgery versus conventional procedures for laparoscopic donor nephrectomy: a Japanese multi-institutional retrospective study2020

    • Author(s)
      LESS and RPS Research Group in Japanese Society of Endourology
    • Journal Title

      Surgical Endoscopy

      Volume: 34 Pages: 3424-3434

    • DOI

      10.1007/s00464-019-07119-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Classification of solid renal tumor with oncocytic/eosinophilic cytoplasm : is hybrid oncocytic/chromophobe renal tumor a subtype of oncocytoma, chromophobe renal cell carcinoma, or a distinct tumor entity?2019

    • Author(s)
      Mikami S, Kuroda N, Nagashima Y, Ohe C, Hayashi H, Mizuno R, Oya M, Kameyama K.
    • Journal Title

      Ann Transl Med

      Volume: Suppl 8

    • DOI

      10.21037/atm.2019.09.77

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors affecting renal function preservation among patients not achieving trifecta after laparoscopic partial nephrectomy for clinical T1a renal masses2019

    • Author(s)
      Takeda Toshikazu、Komatsuda Akari、Yanai Yoshinori、Tanaka Nobuyuki、Matsumoto Kazuhiro、Morita Shinya、Kosaka Takeo、Mizuno Ryuichi、Shinojima Toshiaki、Asanuma Hiroshi、Oya Mototsugu
    • Journal Title

      Asian Journal of Endoscopic Surgery

      Volume: -

    • DOI

      10.1111/ases.12776

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of contrast-enhanced ultrasonography for diagnosis of renal cell carcinoma in dialysis patients2019

    • Author(s)
      Hashimoto Masahiro、Ohkuma Kiyoshi、Akita Hirotaka、Yamada Yoshitake、Nakatsuka Seishi、Mizuno Ryuichi、Oya Mototsugu、Jinzaki Masahiro
    • Journal Title

      Medicine

      Volume: 98

    • DOI

      10.1097/md.0000000000018053

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum Lactate Dehydrogenase Before Nivolumab Treatment Could Be a Therapeutic Prognostic Biomarker for Patients With Metastatic Clear Cell Renal Cell Carcinoma2019

    • Author(s)
      SHIROTAKE SUGURU、TAKAMATSU KIMIHARU、MIZUNO RYUICHI、KANEKO GO、NISHIMOTO KOSHIRO、OYA MOTOTSUGU、OYAMA MASAFUMI
    • Journal Title

      Anticancer Research

      Volume: 39 Pages: 4371-4377

    • DOI

      10.21873/anticanres.13606

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic value of serum C-reactive protein level prior to second-line treatment in intermediate risk metastatic renal cell carcinoma patients2019

    • Author(s)
      Kimiharu Takamatsu, Ryuichi Mizuno, Nobuyuki Tanaka, Toshikazu Takeda, Shinya Morita, Kazuhiro Matsumoto, Takeo Kosaka, Toshiaki Shinojima, Eiji Kikuchi, Hiroshi Asanuma, Masafumi Oyama, Shuji Mikami, Mototsugu Oya
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 24 Pages: 1069-1074

    • DOI

      10.1007/s10147-019-01459-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sub-classification of patients with intermediate-risk metastatic renal cell carcinoma treated with targeted therapy2019

    • Author(s)
      Kaneko Go、Shirotake Suguru、Nishimoto Koshiro、Miyazaki Yasumasa、Ito Keiichi、Ito Yujiro、Hagiwara Masayuki、Kanao Kent、Nakagawa Ken、Momma Tetsuo、Asano Tomohiko、Tanaka Nobuyuki、Mizuno Ryuichi、Oya Mototsugu、Oyama Masafumi
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 49 Pages: 780-785

    • DOI

      10.1093/jjco/hyz067

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical significance of PD-1 and PD-L1 expression in the tumor microenvironment of clear cell renal cell carcinoma.2019

    • Author(s)
      Mikami S, Mizuno R, Kondo T, Shinohara N, Nonomura N, Ozono S, Eto M, Tatsugami K, Takayama T, Matsuyama H, Kishida T, Oya M
    • Journal Title

      Cancer Science

      Volume: 印刷中 Pages: 1820-1828

    • DOI

      10.1111/cas.14019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Is transperitoneal laparoscopic radical nephrectomy suitable for patients with a history of abdominal surgery?2019

    • Author(s)
      Yanai Yoshinori、Takeda Toshikazu、Miyajima Akira、Matsumoto Kazuhiro、Hagiwara Masayuki、Mizuno Ryuichi、Kikuchi Eiji、Asanuma Hiroshi、Oya Mototsugu
    • Journal Title

      Asian Journal of Endoscopic Surgery

      Volume: 12 Pages: 429-433

    • DOI

      10.1111/ases.12673

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] [Ⅳ. Current Economic Issues in Treatment for Metastatic Renal Cell Carcinoma].2019

    • Author(s)
      Mizuno R, Oya M
    • Journal Title

      Gan To Kagaku Ryoho.

      Volume: 46(1) Pages: 50-53

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pre-donation BMI and preserved kidney volume can predict the cohort with unfavorable renal functional compensation at 1-year after kidney donation2019

    • Author(s)
      Shinoda Kazunobu、Morita Shinya、Akita Hirotaka、Tamaki Satoshi、Takahashi Ryohei、Kono Hidaka、Asanuma Hiroshi、Kikuchi Eiji、Jinzaki Masahiro、Nakagawa Ken、Oya Mototsugu
    • Journal Title

      BMC Nephrology

      Volume: 20 Pages: 46-46

    • DOI

      10.1186/s12882-019-1242-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prospective clinical trial of 12-fraction carbon-ion radiotherapy for primary renal cell carcinoma.2019

    • Author(s)
      Kasuya G, Tsuji H, Nomiya T, Makishima H, Haruyama Y, Kobashi G, Hayashi K, Ebner DK, Omatsu T, Kishimoto R, Yasuda S, Igarashi T, Oya M, Akakura K, Suzuki H, Ichikawa T, Shimazaki J, Kamada T
    • Journal Title

      Oncotarget

      Volume: 10(1) Pages: 76-81

    • DOI

      10.18632/oncotarget.26539

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Patients with metastatic renal cell carcinoma who benefit from axitinib dose titration: analysis from a randomised, double-blind phase II study2019

    • Author(s)
      Tomita Yoshihiko、Uemura Hirotsugu、Oya Mototsugu、Shinohara Nobuo、Habuchi Tomonori、Fujii Yosuke、Kamei Yoichi、Umeyama Yoshiko、Bair Angel H.、Rini Brian I.
    • Journal Title

      BMC Cancer

      Volume: 19 Pages: 17-17

    • DOI

      10.1186/s12885-018-5224-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of inflammatory marker levels one month after the first-line targeted therapy initiation on progression-free survival prediction in patients with metastatic clear cell renal cell carcinoma.2019

    • Author(s)
      Ito K, Masunaga A, Tanaka N, Mizuno R, Shirotake S, Yasumizu Y, Ito Y, Miyazaki Y, Hagiwara M, Kanao K, Mikami S, Momma T, Masuda T, Nakagawa K, Oyama M, Asano T, Oya M.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 49(1) Pages: 69-76

    • DOI

      10.1093/jjco/hyy154

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Outcomes in Patients With Metastatic Papillary Renal-Cell Carcinoma: A Multi-Institutional Study in Japan2018

    • Author(s)
      Ito Keiichi、、Nagashima Yoji et al.
    • Journal Title

      Clin Genitourin Cancer.

      Volume: 16

    • DOI

      10.1016/j.clgc.2018.07.028

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Updated long-term outcomes after carbon-ion radiotherapy for primary renal cell carcinoma2018

    • Author(s)
      Kasuya G, Tsuji H, Nomiya T, Makishima H, Haruyama Y, Kobashi G, Ebner DK, Hayashi K, Omatsu T, Kishimoto R, Yasuda S, Igarashi T, Oya M, Akakura K, Suzuki H, Ichikawa T, Shimazaki J, Kamada T
    • Journal Title

      Cancer Science

      Volume: 109 Pages: 2873-2880

    • DOI

      10.1111/cas.13727

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety of pazopanib and sunitinib in treatment-naive patients with metastatic renal cell carcinoma: Asian versus non-Asian subgroup analysis of the COMPARZ trial2018

    • Author(s)
      Guo Jun、Jin Jie、Oya Mototsugu、Uemura Hirotsugu、Takahashi Shunji、Tatsugami Katsunori、Rha Sun Young、Lee Jae-Lyun、Chung Jinsoo、Lim Ho Yeong、Wu Hsi Chin、Chang Yen Hwa、Azad Arun、Davis Ian D.、Carrasco-Alfonso Marlene J.、Nanua Bhupinder、Han Jackie、Ahmad Qasim、Motzer Robert
    • Journal Title

      Journal of Hematology & Oncology

      Volume: 11 Pages: 69-69

    • DOI

      10.1186/s13045-018-0617-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and safety of sorafenib for advanced renal cell carcinoma: real-world data of patients with renal impairment.2018

    • Author(s)
      Tatsugami K, Oya M, Kabu K, Akaza H
    • Journal Title

      Oncotarget.

      Volume: 9(27) Pages: 19406-19414

    • DOI

      10.18632/oncotarget.24779

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic Value of Baseline Serum C-Reactive Protein Level in Intermediate-Risk Group Patients With Metastatic Renal-Cell Carcinoma Treated by First-Line Vascular Endothelial Growth Factor-Targeted Therapy.2018

    • Author(s)
      Takamatsu K1, Mizuno R2, Omura M1, Morita S1, Matsumoto K1, Shinoda K1, Kosaka T1, Takeda T1, Shinojima T1, Kikuchi E1, Asanuma H1, Oyama M3, Mikami S4, Oya M1.
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: 16(4)

    • DOI

      10.1016/j.clgc.2018.03.012

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preliminary results for avelumab plus axitinib as first-line therapy in patients with advanced clear-cell renal-cell carcinoma (JAVELIN Renal 100): an open-label, dose-finding and dose-expansion, phase 1b trial2018

    • Author(s)
      Choueiri TK, Larkin J, Oya M, Thistlethwaite F, Martignoni M, Nathan P, Powles T, McDermott D, Robbins PB, Chism DD, Cho D, Atkins MB, Gordon MS, Gupta S, Uemura H, Tomita Y, Compagnoni A, Fowst C, di Pietro A, Rini BI.
    • Journal Title

      The Lancet Oncology

      Volume: 19 Pages: 451-460

    • DOI

      10.1016/s1470-2045(18)30107-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of efficacy and safety of sorafenib in kidney cancer patients aged 75 years and older: a propensity score-matched analysis2018

    • Author(s)
      Tatsugami Katsunori、Oya Mototsugu、Kabu Koki、Akaza Hideyuki
    • Journal Title

      British Journal of Cancer

      Volume: 119 Pages: 241-247

    • DOI

      10.1038/s41416-018-0129-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 腫瘍免疫学的分類(Immuno-clustering)による腎細胞癌の新しいサブクラス分類と臨床的有用性2020

    • Author(s)
      髙松 公晴, 田中 伸之, 三上 修治, 箱崎 恭平, 髙橋 遼平, 武田 利和, 森田 伸也, 松本 一宏, 小坂 威雄, 水野 隆一, 浅沼 宏, 垣見 和宏, 大家 基嗣
    • Organizer
      第108回日本泌尿器科学会総会
    • Related Report
      2020 Annual Research Report
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    • Author(s)
      高橋 遼平, 田中 伸之, 宮 冬樹, 鎌谷 高志, 武田 利和, 松本 一宏, 森田 伸也, 小坂 威雄, 水野 隆一, 三上 修治, 垣見 和宏, 角田 達彦, 大家 基嗣
    • Organizer
      第108回日本泌尿器科学会総会
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  • [Presentation] 転移性腎癌における転移巣完全切除の臨床的効果2020

    • Author(s)
      高松 公晴, 水野 隆一, 安水 洋太, 田中 伸之, 武田 利和, 森田 伸也, 松本 一宏, 小坂 威雄, 浅沼 宏, 大東 貴志, 大家 基嗣
    • Organizer
      第58回日本癌治療学会学術集会
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      2020 Annual Research Report
  • [Presentation] 淡明型腎細胞癌における三次リンパ様構造(TLS)の臨床病理学的検討2020

    • Author(s)
      桝田 司, 田中 伸之, 箱崎 恭平, 高松 公晴, 安水 洋太, 武田 利和, 松本 一宏, 森田 伸也, 小坂 威雄, 水野 隆一, 浅沼 宏, 三上 修治, 大家 基嗣
    • Organizer
      第58回日本癌治療学会学術集会
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  • [Presentation] 進行性腎細胞癌favorableリスク群における予後因子の検討2020

    • Author(s)
      水野 隆一, 高松 公晴, 安水 洋太, 田中 伸之, 森田 伸也, 松本 一宏, 武田 利和, 小坂 威雄, 浅沼 宏, 大家 基嗣
    • Organizer
      第58回日本癌治療学会学術集会
    • Related Report
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  • [Presentation] 淡明細胞型腎細胞癌におけるAXL発現の腫瘍内不均一性と予後の検討2020

    • Author(s)
      箱崎 恭平, 田中 伸之, 高松 公晴, 安水 洋太, 武田 利和, 松本 一宏, 森田 伸也, 小坂 威雄, 水野 隆一, 浅沼 宏, 大家 基嗣
    • Organizer
      第58回日本癌治療学会学術集会
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  • [Presentation] Prognostic value of serum C-reactive protein level prior to second-line treatment in intermediate risk metastatic renal cell carcinoma patients.2019

    • Author(s)
      Takamatsu K, Mizuno R, Hayakawa N, Kikuchi E, Kosaka T, Oya M
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    • Organizer
      ASCO Annual Meeting
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    • Author(s)
      Mizuno R, Mikami S, Takamatsu K, Hayakawa N, Kosaka T, Kikuchi E, Oya M
    • Organizer
      ASCO Annual Meeting
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    • Author(s)
      Takamatsu K, Mizuno R, Hayakawa N, Kosaka T, Kikuchi E, Mikami S, Oya M
    • Organizer
      ASCO Annual Meeting
    • Related Report
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  • [Remarks] 慶應義塾大学医学部 泌尿器科学教室ホームページ

    • URL

      http://www.keio-urology.jp/

    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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