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Measurement platform of nano-vibration in the cochlea for understanding the pathogenesis in deafness model mice

Research Project

Project/Area Number 18H02950
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionGifu University (2020)
Niigata University (2018-2019)

Principal Investigator

Nin Fumiaki  岐阜大学, 大学院医学系研究科, 教授 (80644905)

Co-Investigator(Kenkyū-buntansha) 吉川 欣亮  公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, プロジェクトリーダー (20280787)
太田 岳  大阪大学, 医学系研究科, 助教 (30790571)
崔 森悦  新潟大学, 自然科学系, 准教授 (60568418)
日比野 浩  大阪大学, 医学系研究科, 教授 (70314317)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywordsナノ振動 / 感覚上皮帯 / in vivo計測 / 蝸牛 / 外有毛細胞 / 基底板 / 位置ずれ / マウス / 内耳 / レーザー干渉計
Outline of Final Research Achievements

Audition is indispensable for human activity. In this study, we focused on the vibration of sensory epithelium in the cochlea of the inner ear. The vibration behavior in in vivo condition is still unknown. We developed a new measurement system called Dual SPM (sinusoidal phase modulation) laser interferometer, which detects baseline shift as well as vibration amplitude and phase. In addition, we recorded these parameters of the epithelial vibration under general anesthesia in live guinea pig. When we applied the sound which is known frequency and intensity, the baseline shift was observed. Moreover, we pharmacologically exhibited the baseline shift attributed from the outer hair cells’ function by applying drugs.

Academic Significance and Societal Importance of the Research Achievements

他の感覚に比較して極めて聴覚の特性は、感覚上皮帯のナノスケールの微小振動に依拠する。超高齢化社会を迎える我が国で増加している難聴は、患者数が1,000万人を超え、他の感覚疾患や脳卒中の罹患者より段違いに多い。しかし、病因の大部分は不明のため、治療薬や治療法は30年以上もの間、殆ど進歩がなく、その開発は喫緊の課題である。現在原因不明の難聴の多くは蝸牛の異常に起因する。本研究成果は、位置ずれという新しいナノ振動様式の観点から、難聴病態の解明にアクセスできる可能性を示したものであり、今後実際に利用可能な難聴モデル動物の解析を通じて、病態解明と新たな治療方法の提案に貢献できる可能性がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(16 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Imperial College Londonondon(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Imperial College London(英国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Optimization of spectral-domain optical coherence tomography with a supercontinuum source for in vivo motion detection of low reflective outer hair cells in guinea pig cochleae2021

    • Author(s)
      Nin Fumiaki、Choi Samuel、Ota Takeru、Qi Zhang、Hibino Hiroshi
    • Journal Title

      Optical Review

      Volume: 28 Pages: 239-254

    • DOI

      10.1007/s10043-021-00654-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterisation of the static offset in the travelling wave in the cochlear basal turn2020

    • Author(s)
      T. Ota, F. Nin, S. Choi, S. Muramatsu, S. Sawamura, G. Ogata, M. P. Sato, Kat. Doi, K. Doi, T. Tsuji, S. Kawano, T. Reichenbach, and H. Hibino
    • Journal Title

      PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

      Volume: 472 Pages: 1-11

    • DOI

      10.1007/s00424-020-02373-6

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 内耳感覚上皮帯のナノ振動2019

    • Author(s)
      太田 岳、任 書晃、日比野 浩
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 1479-1480

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 感音難聴治療のための聴覚生理の新知見2019

    • Author(s)
      任 書晃、太田 岳、日比野 浩
    • Journal Title

      JOHNS

      Volume: 36 Pages: 10-14

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 内耳蝸牛の感覚上皮帯におけるナノ振動計測を志向したOCT2019

    • Author(s)
      任 書晃
    • Journal Title

      光学

      Volume: 48 Pages: 160-163

    • Related Report
      2019 Annual Research Report
  • [Presentation] モルモット基底回転における外有毛細胞のin vivoナノ振動動態計測2020

    • Author(s)
      任 書晃、太田 岳、崔 森悦、日比野 浩
    • Organizer
      第121回日本耳鼻咽喉科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 内耳の感覚上皮帯を構成する外有毛細胞のナノ振動動態の同定2020

    • Author(s)
      任 書晃、太田 岳、崔 森悦、日比野 浩
    • Organizer
      第67回中部日本生理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 高解像コヒーレンストモグラフィを用いた蝸牛外有毛細胞のナノ振動動態計測2020

    • Author(s)
      任 書晃、太田 岳、崔 森悦、日比野 浩
    • Organizer
      生理学研究所研究会「シグナル動態の可視化と操作に基づく多階層機能解析の新展開」
    • Related Report
      2020 Annual Research Report
  • [Presentation] 内耳の感覚上皮帯を構成する有毛細胞のナノ動態の同定日本薬理学会北部会2019

    • Author(s)
      任 書晃、太田 岳、崔 森悦、日比野 浩
    • Organizer
      日本薬理学会北部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Contribution of nonecitable epithelial tissue in the inner ear to an electrical response used for clinical diagnosis of hearing disorders.2019

    • Author(s)
      張 奇、任 書晃、吉田 崇正、太田 岳、日比野 浩
    • Organizer
      日本薬理学会北部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 内耳の感覚上皮帯を構成する外有毛細胞のナノ動態の同定2019

    • Author(s)
      任 書晃、太田 岳、崔 森悦、日比野 浩
    • Organizer
      中部日本生理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 改良型レーザ干渉計による内耳蝸牛の感覚上皮帯ナノ振動測定2018

    • Author(s)
      太田 岳、崔 森悦、任 書晃、日比野 浩
    • Organizer
      第28回日本耳科学会総会・学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 内耳の感覚上皮帯に生じるナノ振動の抽出とその調節機構の検討2018

    • Author(s)
      太田 岳、任 書晃、崔 森悦、日比野 浩
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Detection of an atypical motion in cochlear sensory epithelium.2018

    • Author(s)
      Ota T, Nin F, Choi S, Hibino H.
    • Organizer
      9th FAOPS Federation of the Asian and Oceanian Physiological Societies Congress.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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