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Elucidation of stem cell competencies for periodontal tissue regeneration and application to cell transplantation therapy

Research Project

Project/Area Number 18H02976
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionOsaka University

Principal Investigator

Takedachi Masahide  大阪大学, 歯学部附属病院, 講師 (60452447)

Co-Investigator(Kenkyū-buntansha) 藤原 千春  大阪大学, 歯学研究科, 助教 (00755358)
山口 佳則  大阪大学, 工学研究科, 招へい教授 (20386634)
大倉 華雪  地方独立行政法人大阪府立病院機構大阪はびきの医療センター(臨床研究センター), 次世代創薬創生センター, 研究員(移行) (20589684)
村上 伸也  大阪大学, 歯学研究科, 教授 (70239490)
岩山 智明  大阪大学, 歯学研究科, 助教 (80757865)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords歯周組織再生 / 幹細胞移植 / 再生医療 / 脂肪組織由来多系統前駆細胞 / コンピテンシー
Outline of Final Research Achievements

Adipose tissue-derived multilineage progenitor cells, which has been used for clinical study to induce periodontal tissue regeneration, were classified based on the clinically obtained difference in efficacy of periodontal tissue regeneration. By profiling the characteristics by secretome and transcriptome analysis, we obtained multifaceted information about the competency of stem cells required to regenerate periodontal tissue. In addition, it has been suggested that differences in hypoxia signals, TGF-SMAD signal and apoptosis-related signal was involved in periodontal tissue regeneration ability.

Academic Significance and Societal Importance of the Research Achievements

再生医療に用いられるヒト由来細胞には、ドナー由来の個体差があることは周知であるにも関わらず、これまでにその不均一性と治療効果との関係を検証した報告はなかった。本研究課題にて得られた研究成果は細胞の自己移植治療における有効性向上のみならず、他家由来の細胞を用いた再生医療等製品の開発による歯周組織再生医療の開発につながる貴重な情報になるものと考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (7 results)

All 2021 2019

All Presentation (7 results) (of which Invited: 3 results)

  • [Presentation] 脂肪組織由来多系統前駆細胞移植による歯周組織再生療法の近未来2021

    • Author(s)
      竹立匡秀、村上伸也
    • Organizer
      第20回日本再生医療学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脂肪組織由来多系統前駆細胞(ADMPC)由来Trophic因子のプロテオーム解析2019

    • Author(s)
      沢田啓吾、竹立匡秀、森本千晶、平井麻絵、下村純平、川嵜公輔、岩山智明、北村正博、 村上伸也
    • Organizer
      日本プロテオーム学会2019年大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Therapeutic efficacy and Stem cell characteristics association in Stem cell transplantation therapy.2019

    • Author(s)
      Takedachi M, Sawada K, Morimoto C, Hirai A, Shimomura J, Kawasaki K, Iwayama T, Kitamura M, Murakami S
    • Organizer
      13th Asian Pacific Society of periodontology
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脂肪組織由来多系統前駆細胞の自己移植による歯周組織再生療法の開発2019

    • Author(s)
      竹立匡秀
    • Organizer
      第37回日本骨代謝学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脂肪組織由来多系統前駆細胞移植による歯周組織再生医療の開発2019

    • Author(s)
      竹立匡秀
    • Organizer
      第62回秋季日本歯周病学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Shotgun Proteomic Analysis of the humoral factors derived from ADMPC.2019

    • Author(s)
      Sawada K, Takedachi M, Morimoto C, Hirai A, Shimomura J, Kawasaki K, Iwayama T, Kitamura M, Murakami S
    • Organizer
      4th Meeting of the International Association for Dental Research Asia Pacific Region 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自己脂肪組織由来多系統前駆細胞移植による歯周組織再生療法の開発2019

    • Author(s)
      竹立匡秀、村上伸也
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Annual Research Report
    • Invited

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Published: 2018-04-23   Modified: 2022-01-27  

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