Analysis of stress-induced senescent cells to elucidate the unknown inhibitory mechanism of bone formation
| Project/Area Number |
18H02986
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 57040:Regenerative dentistry and dental engineering-related
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
橋本 典也 大阪歯科大学, 歯学部, 教授 (20228430)
片岡 宏介 徳島大学, 大学院医歯薬学研究部(歯学域), 教授 (50283792)
田中 知成 京都工芸繊維大学, 繊維学系, 准教授 (70585695)
南部 隆之 大阪歯科大学, 歯学部, 講師 (80367903)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Keywords | 老化細胞 / 老化 / 細胞老化 / 骨 / 再生 / 生体材料 / ストレス誘導性老化 / 骨再生 / 骨形成 / カテキン / ストレス / 再生医療 |
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| Outline of Final Research Achievements |
The aim of this project was to elucidate the behavior and molecular mechanisms of senescent cells and SASP-related factors that inhibit bone formation, which can be useful to develop next-generation bone regeneration therapies free from this inhibition mechanism. Our results revealed that stress-induced premature senescent cells induced by stimuli from lipopolysaccharide or material implantation can be involved in the inhibitory mechanism of bone regeneration.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果、リポ多糖あるいは材料埋入によりストレス誘導性早期老化細胞が誘導され、同細胞が骨再生の阻害に関与している可能性が明らかとなった。これらの知見は、未知なる骨再生阻害メカニズムの解明に繋がりうる知見であり、関連する細胞老化随伴分泌現象因子などの解明が更に進めば、既存の治療法とは異なる新規再生医療やバイオマテリアルの開発などに道を拓くと予想される。
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Report
(5 results)
Research Products
(11 results)
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[Journal Article] Sustained Release of Catechin from Gelatin and Its Effect on Bone Formation in Critical Sized Defects in Rat Calvaria2020
Author(s)
Honda Y, Huang A, Zhao J, Han X, Kurushima Y, Gong Y, Kanzaki H, Katsumata Y, Yamada Y, Hashimoto Y, Matsumoto N, Baba S, Tanaka T, Umeda M
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Journal Title
Journal of Hard Tissue Biology
Volume: 29
Issue: 2
Pages: 77-84
DOI
NAID
ISSN
1341-7649, 1880-828X
Related Report
Peer Reviewed / Open Access
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